An introduction to high speed aircraft noise prediction

The Aircraft Noise Prediction Program's High Speed Research prediction system (ANOPP-HSR) is introduced. This mini-manual is an introduction which gives a brief overview of the ANOPP system and the components of the HSR prediction method. ANOPP information resources are given. Twelve of the most common ANOPP-HSR control statements are described. Each control statement's purpose and format are stated and relevant examples are provided. More detailed examples of the use of the control statements are presented in the manual along with ten ANOPP-HSR templates. The purpose of the templates is to provide the user with working ANOPP-HSR programs which can be modified to serve particular prediction requirements. Also included in this manual is a brief discussion of common errors and how to solve these problems. The appendices include the following useful information: a summary of all ANOPP-HSR functional research modules, a data unit directory, a discussion of one of the more complex control statements, and input data unit and table examples

Formation of complex self-assembled aggregates in non-ionic chromonics: dimer and trimer columns, layer structures and spontaneous chirality

Dissipative particle dynamics (DPD) simulations are used to model the aqueous self-assembly of three variants of the non-ionic triphenylene-based chromonic mesogen, TP6EO2M. In the variants studied, one to three of the six methoxy poly(ethylene glycol) chains of TP6EO2M are replaced by short hydrophobic-lipophobic chains, causing a remarkable change in the structure of the mesophases formed. In the 100 wt% limit, corresponding to pure thermotropic phases, complex columnar phases arise, in which the underlying hexagonal packing is supplemented by additional order resulting from microphase separation of hydrophobic-lipophobic regions. With addition of water an array of novel chromonic phases are seen. In these phases supramolecular aggregates form in which hydrophobic-lipophobic chains are excluded from water by the joining together of single molecule chromonic stacks into dimers or trimers. These aggregates form chromonic N and M phases and, in the case of a “Janus mesogen” (with three hydrophobic-lipophobic chains on one side of the molecule), form a novel smectic chromonic phase. Spontaneous symmetry breaking is seen in columns composed of trimer stacks with defects. Here achiral molecular aggregates develop a spontaneous twist, inducing the formation of either left-handed or right-handed chiral aggregates. On the long time-scales accessible to DPD simulations, chiral aggregates are seen to be dynamic structures in which chirality inversion can take place over long periods of time

Random and exhaustive generation of permutations and cycles

In 1986 S. Sattolo introduced a simple algorithm for uniform random generation of cyclic permutations on a fixed number of symbols. This algorithm is very similar to the standard method for generating a random permutation, but is less well known. We consider both methods in a unified way, and discuss their relation with exhaustive generation methods. We analyse several random variables associated with the algorithms and find their grand probability generating functions, which gives easy access to moments and limit laws.Comment: 9 page

Mitochondria as a Potential Antifungal Target for Isocyanide Compounds

The discovery of antibiotics and antifungals greatly impacted medicine and human health, allowing the effective treatment of infections that were previously deadly. However, due to routine and sometimes excessive usage of these compounds, the development of antimicrobial resistance has created a need for new antibiotic and antifungal compounds. Isocyanide compounds have been shown to have antibacterial, antifungal, and anti-cancer properties, but very little is known about their biochemical effects. Our research aims to understand the mechanism of action of isocyanide compounds. We have conducted a genetic screen of a Saccharomyces gene-deletion (“knockout”) collection on media containing an easily synthesized model isocyanide compound, para-nitrophenyl isocyanide (p-NPIC). This allowed us to identify genes which, when deleted, render the mutant strains resistant or hypersensitive to the compound. Based on our genetic screen for hypersensitive mutants, we hypothesize that the isocyanides impact mitochondrial function, specifically altering the function of the Cu++-containing respiratory complex, Cytochrome C Oxidase (Complex IV). Our findings provide new information on the mechanism(s) of action of this class of antimicrobials and will help guide the development of new molecules based on lead-compounds such as p-NPIC

Role of Peptide Backbone Conformation on Biological Activity of Chemotactic Peptides

To investigate the role of peptide backbone conformation on the biological activity of chemotactic peptides, we synthesized a unique analog of N-formyl-Met-Leu-Phe-OH incorporating the C α,α disubstituted residue, dipropylglycine (Dpg) in place of Leu. The conformation of the stereochemically constrained Dpg analog was examined in the crystalline state by x-ray diffraction and in solution using NMR, IR, and CD methods. The secretagogue activity of the peptide on human neutrophils was determined and compared with that of a stereochemically constrained, folded type II β-turn analog incorporating 1-aminocyclohexanecarboxylic acid (Ac6c) at position 2 (f-Met- Ac6c -Phe-OMe), the parent peptide (f-Met-Leu-Phe-OH) and its methyl ester derivative (f-Met-Leu-Phe-OMe). In the solid state, the Dpg analog adopts an extended β-sheet-like structure with an intramolecular hydrogen bond between the NH and CO groups of the Dpg residue, thereby forming a fully extended (C5) conformation at position 2. The ϕ and ψ values for Met and Phe residues are significantly lower than the values expected for an ideal antiparallel beta conformation causing a twist in the extended backbone both at the N and C termini. Nuclear magnetic resonance studies suggest the presence of a significant population of the peptide molecules in an extended antiparallel β conformation and the involvement of Dpg NH in a C5 intramolecular hydrogen bond in solutions of deuterated chloroform and deuterated dimethyl sulfoxide. IR studies provide evidence for the presence of an intramolecular hydrogen bond in the molecule and the antiparallel extended conformation in chloroform solution. CD spectra in methanol, trifluoroethanol, and trimethyl phosphate indicate that the Dpg peptide shows slight conformational flexibility, whereas the folded Ac6c analog is quite rigid. The extended Dpg peptide consistently shows the highest activity in human peripheral blood neutrophils, being approximately 8 and 16 times more active than the parent peptide and the folded Ac6c analog, respectively. However, the finding that all four peptides have ED50 (the molar concentration of peptide to induce half-maximal enzyme release) values in the 10(-8)-10(-9) M range suggests that an induced fit mechanism may indeed be important in this ligand-receptor interaction. Moreover, it is also possible that alterations in the backbone conformation at the tripeptide level may not significantly alter the side chain topography and/or the accessibility of key functional groups important for interaction with the receptor

The Effects of Linear Microphone Array Changes on Computed Sound Exposure Level Footprints

Airport land planning commissions often are faced with determining how much area around an airport is affected by the sound exposure levels (SELS) associated with helicopter operations. This paper presents a study of the effects changing the size and composition of a microphone array has on the computed SEL contour (ground footprint) areas used by such commissions. Descent flight acoustic data measured by a fifteen microphone array were reprocessed for five different combinations of microphones within this array. This resulted in data for six different arrays for which SEL contours were computed. The fifteen microphone array was defined as the 'baseline' array since it contained the greatest amount of data. The computations used a newly developed technique, the Acoustic Re-propagation Technique (ART), which uses parts of the NASA noise prediction program ROTONET. After the areas of the SEL contours were calculated the differences between the areas were determined. The area differences for the six arrays are presented that show a five and a three microphone array (with spacing typical of that required by the FAA FAR Part 36 noise certification procedure) compare well with the fifteen microphone array. All data were obtained from a database resulting from a joint project conducted by NASA and U.S. Army researchers at Langley and Ames Research Centers. A brief description of the joint project test design, microphone array set-up, and data reduction methodology associated with the database are discussed

Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator

Alpha-macroglobulins are ancient proteins that include monomeric, dimeric, and tetrameric family members. In humans, and many other mammals, the predominant alpha-macroglobulin is alpha-2-macroglobulin (α2M), a tetrameric protein that is constitutively abundant in biological fluids (e.g., blood plasma, cerebral spinal fluid, synovial fluid, ocular fluid, and interstitial fluid). α2M is best known for its remarkable ability to inhibit a broad spectrum of proteases, but the full gamut of its activities affects diverse biological processes. For example, α2M can stabilise and facilitate the clearance of the Alzheimer’s disease-associated amyloid beta (Aβ) peptide. Additionally, α2M can influence the signalling of cytokines and growth factors including neurotrophins. The results of several studies support the idea that the functions of α2M are uniquely regulated by hypochlorite, an oxidant that is generated during inflammation, which induces the native α2M tetramer to dissociate into dimers. This review will discuss the evidence for hypochlorite-induced regulation of α2M and the possible implications of this in neuroinflammation and neurodegeneration

Computational predictions of interfacial tension, surface tension, and surfactant adsorption isotherms

All-atom (AA) molecular dynamics (MD) simulations are employed to predict interfacial tensions (IFT) and surface tensions (ST) of both ionic and non-ionic surfactants. The general AMBER force field (GAFF) and variants are examined in terms of their performance in predicting accurate IFT/ST, γ, values for chosen water models, together with the hydration free energy, ΔGhyd, and density, ρ, predictions for organic bulk phases. A strong correlation is observed between the quality of ρ and γ predictions. Based on the results, the GAFF-LIPID force field, which provides improved ρ predictions is selected for simulating surfactant tail groups. Good γ predictions are obtained with GAFF/GAFF-LIPID parameters and the TIP3P water model for IFT simulations at a water–triolein interface, and for GAFF/GAFF-LIPID parameters together with the OPC4 water model for ST simulations at a water–vacuum interface. Using a combined molecular dynamics-molecular thermodynamics theory (MD-MTT) framework, a mole fraction of C12E6 molecule of 1.477 × 10−6 (from the experimental critical micelle concentration, CMC) gives a simulated surface excess concentration, ΓMAX, of 76 C12E6 molecules at a 36 nm2 water–vacuum surface (3.5 × 10−10 mol cm−2), which corresponds to a simulated ST of 35 mN m−1. The results compare favourably with an experimental ΓMAX of C12E6 of 3.7 × 10−10 mol cm−2 (80 surfactants for a 36 nm2 surface) and experimental ST of C12E6 of 32 mN m−1 at the CMC

Exploring mini rugby union coaches’ perceptions of competitive activities

The purpose of this study was to explore volunteer rugby union coaches’ perceptions of organised competitive participation during childhood. Participants were 202 under-9 (U9) mini rugby union coaches who had coached during the 2010/11 season. Coaches completed an Internet-based survey, and cluster analysis was used to identify different groups based on attitudes towards the Rugby Football Union’s current rules and proposed changes to these rules. Three distinct groups were identified based on whether they wanted to maintain the status quo (Traditionalists); maintain some elements of structure (Moderates); or have a much less structured introduction to rugby (Radicals). In total, over three quarters of coaches favoured structured elements (early specialisation), while less than a quarter favoured a less structured game (late specialisation). Only the Radical’s views matched those espoused by elite coaches and U9 players themselves, raising several issues regarding coach education for player development during childhood. In the short term there are the difficulties of aligning disparate views of U9 player development via coaching for and during competitive games. This is further complicated by the challenges of enhancing the skills of thousands of volunteer coaches with limited experience, knowledge and expertise in coaching during childhood

Occupation, Occupational Change and Movement within the Income Distribution

The authors find considerable earnings mobility in panel data of a sample of white males and associate occupational mobility with these changes in real labor earnings, both in absolute terms and relative to an income distribution. Results of an error-components estimation reveal that occupation and movement among occupations exert strong influences on earnings changes even after controlling for a number of other factors. Effects of the interdependence of earnings and occupational mobility, the state of the pairings, and a variety of personal characteristics are also studied.