3,994 research outputs found
Confidential Communication Privileges Under Federal and Virginia Law
This Comment focuses on the confidential communication privileges recognized under federal and Virginia law. The history of rule 501 of the Federal Rules of Evidence is discussed in order to illustrate the policies which Congress intended to further by enacting it and to shed some light on how Congress intended the rule to operate. Discussion includes an examination of various trends or approaches which recent federal decisions have taken in applying rule 501. Finally, specific privileges which have been recognized by federal courts and specific privileges recognized under Virginia law are enumerated
Practice and Procedure
Covers cases on default judgment—failure of complaint to state facts sufficient to constitute cause of action—waiver of right to attack complaint
Module identification in bipartite and directed networks
Modularity is one of the most prominent properties of real-world complex
networks. Here, we address the issue of module identification in two important
classes of networks: bipartite networks and directed unipartite networks. Nodes
in bipartite networks are divided into two non-overlapping sets, and the links
must have one end node from each set. Directed unipartite networks only have
one type of nodes, but links have an origin and an end. We show that directed
unipartite networks can be conviniently represented as bipartite networks for
module identification purposes. We report a novel approach especially suited
for module detection in bipartite networks, and define a set of random networks
that enable us to validate the new approach
Intellectual engagement and cognitive ability in later life (the "use it or lose it" conjecture) : Longitudinal, prospective study
Data sharing: All data are available by application to the Aberdeen Birth Cohort steering group (https://www.abdn.ac.uk/birth-cohorts/1921/for-researchers/).Peer reviewedPublisher PD
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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here we report the systematic discovery of molecules that potently inhibit both tyrosine kinases and phosphatidylinositol-3-OH kinases, two protein families that are among the most intensely pursued cancer drug targets. Through iterative chemical synthesis, X-ray crystallography and kinome-level biochemical profiling, we identified compounds that inhibit a spectrum of new target combinations in these two families. Crystal structures revealed that the dual selectivity of these molecules is controlled by a hydrophobic pocket conserved in both enzyme classes and accessible through a rotatable bond in the drug skeleton. We show that one compound, PP121, blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases. These molecules demonstrate the feasibility of accessing a chemical space that intersects two families of oncogenes
Thin metal electrode for AMTEC
An electrode having higher power output is formed of a thin, porous film (less than 1 micrometer) applied to a beta-alumina solid electrolyte (BASE). The electrode includes an open grid, current collector such as a series of thin, parallel, grid lines applied to the thin film and a plurality of cross-members such as loop of metal wire surrounding the BASE tube. The loops are electrically connected by a bus wire. The overall impedance of the electrode considering both the contributions from the bulk BASE and the porous electrode BASE interface is low, about 0.5 OHM/cm.sup.2 and power densities of over 0.3 watt/cm.sup.2 for extended periods
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