Racial Disparities in Cancer Screening Among Women with Chronic Joint Pain

Chronic pain related disorders and breast and cervical cancer are more prevalent among African-American women compared with non-Hispanic White women. However, few studies address how racial differences in the context of comorbidity may compound these disparities. This study used secondary analysis of the National Health Interview Survey (NHIS) to assess racial differences in breast and cervical cancer screening and patient education among adult women with chronic joint pain conditions. Statistical analyses included chi-square and independent samples t-tests. African-American women compared with non-Hispanic White women were less likely to receive a pap smear or mammogram within the last two years and receive patient education (p\u3c0.01). Due to competing demands, women with chronic joint pain may not receive preventive services. The results of this study can be used to formulate interventions and evaluate approaches to reduce racial disparities in outpatient service delivery in terms of continuity and scope of care

Conformational isomers of linear rotaxanes

We examine a simple model of rotaxane structure, with 3 asymmetric rings interacting via repulsive power-law forces. This interlocked molecule exhibits conformational isomerisation which is different from that of molecules whose connectedness is through covalent bonds. The rings are free to translate along and rotate around the axle, and hence weak interaction forces between the rings can lead to distinct rotamer states. We use energy minimisation to determine these states exactly, and show that there can be transitions from asymmetric to symmetric states by varying the bond lengths. We also use classical statistical mechanics to show the effect of thermal noise

Experimental study of the fluctuation theorem in a nonequilibrium steady state

The fluctuation theorem (FT) quantifies the probability of second law violations in small systems over short time scales. While this theorem has been experimentally demonstrated for systems that are perturbed from an initial equilibrium state, there are a number of studies suggesting that the theorem applies asymptotically in the long time limit to systems in a nonequilibrium steady state. The asymptotic application of the FT to such nonequilibrium steady states has been referred to in the literature as the steady-state fluctuation theorem (or SSFT). In this paper, we demonstrate experimentally the application of the FT to nonequilibrium steady states, using a colloidal particle localized in a translating optical trap. Furthermore, we show, for this colloidal system, that the FT holds under nonequilibrium steady states for all time, and not just in the long time limit, as in the SSFT

Coarse-graining intramolecular hydrodynamic interaction in dilute solutions of flexible polymers

We present a scheme for coarse-graining hydrodynamic interactions in an isolated flexible homopolymer molecule in solution. In contrast to the conventional bead-spring model that employs spherical beads of fixed radii to represent the hydrodynamic characteristics of coarse-grained segments, we show that our procedure leads naturally to a discrete model of a polymer molecule as a chain of orientable and stretchable Gaussian blobs. This model accounts for both intrablob and interblob hydrodynamic interactions, which depend on the instantaneous shapes of the blobs. In Brownian dynamics simulations of initially stretched chains relaxing under quiescent conditions, the transient evolution of the mean-square end-to-end distance and first normal stress difference obtained with the Gaussian-blob model are found to be less sensitive to the degree of coarse graining, in comparison with the conventional bead-spring model with Rotne-Prager-Yamakawa hydrodynamic interactions

Prolonged Injustice in Urban America

Environmental inequality is the suggestion that the working class, the poor, persons of color, and ultimately the economically disadvantaged are subjected to living conditions that may prove to be hazardous both personally, professionally, and also to the infrastructure of the urban communities that these people inhabit. These injustices affect not only housing but education, quality healthcare access, and access to employment. This article investigates the distinct relationship of environmental inequalities imposed in urban communities that are promoted by a prominent institution: the government. It has been suggested that the government is primarily controlled by individuals who are incapable of identifying with individuals who are residents of these urban communities susceptible to the threat of environmental inequality. This introduces multiple questions: Are political leaders less concerned with such individuals and is this why the needed attention in these communities is positioned at the bottom of the agenda if it appears at all? This, in addition to the lack of funding distributed among these regions for improvements, demonstrates the neglect of the government and how this maintains environmental injustice in urban areas

Climate Change, Environmental Justice, and Vulnerability: An Exploratory Spatial Analysis

Research has demonstrated that vulnerable populations including disadvantaged populations of color live in areas that may place them at higher risk of exposure to social and environmental hazards. Due to climate change, these populations may experience worse health outcomes and environmental health disparities. The purpose of this project was to explore the use of Geographic Information Systems (GIS) to assess areas that may be vulnerable to climate change across the United States. We employed ArcGIS 9.3 to create vulnerability scores for areas across the country that may be that may be impacted by climate change at the county level in the United States using different social, environmental, and health indicators. We included data on race=ethnicity and socioeconomic status from the US Census. Data on pollution sources and pollution levels were obtained from the United States Environmental Protection Agency. Health data were obtained from the Behavioral Risk Factor Surveillance System (BRFSS), the National Vital Statistics System, and the National Center for Health Statistics. We also employed the Moran’s I statistic to assess any significant vulnerability clusters. We found the highest scores for counties in the South particularly the Deep South and in Metropolitan areas in the Northeast and Midwest. Our findings provide insight into the areas of the country that may be vulnerable to the impacts of climate-change. More work needs to be performed to improve the spatial resolution of the maps and include more physical data that will help target areas that need effective climate change related mitigation and adaptation policies

Media Attention on African Americans with Human Immunodeficiency Virus

Human immunodeficiency virus (HIV) is a disease that has captured the attention of the media in various ways and to varying degrees. One of the ongoing debates and areas of research in HIV that provide many opportunities for discovery is the disproportionate number of African Americans infected with HIV compared to the amount of attention they receive in the media. This manuscript addresses the question that has preoccupied the minds of many people: Why have African Americans infected with HIV received so little media attention? Analysis of this question suggests that there are many reasons for this lack of media attention. One reason in particular is the media tends to be much less attentive to diseases, such as HIV, that disproportionately burden blacks relative to whites. We also find that the media is reluctant to write about HIV in African Americans because it portrays them negatively. The media suggests that people are bombarded with negative news about African Americans and writing about them with regard to HIV only reinforces the negative. Finally, analysis reveals that in recent years African Americans with HIV have received more media attention due to the increase in rates of HIV in African Americans. This increase in media attention helps educate African Americans about the disease, reduces the stigma associated with it, and inspires African Americans to get tested and linked to care. In this way, African Americans with HIV can help the community stay virus-free

The Community-Driven Approach to Environmental Exposures: How a Community-Based Participatory Research Program Analyzing Impacts of Environmental Exposure on Lupus Led to a Toxic Site Cleanup

Community-based participatory research (CBPR) is a mechanism to improve environmental quality in communities primarily inhabited by minorities or low income families. A collaborative partnership between the University at Buffalo and the Toxic Waste Lupus Coalition was formed to investigate the high prevalence of lupus in the area and whether cases of disease were linked to chemicals found at a nearby New York State Superfund site in East Buffalo. The purpose of the study was to use CBPR practices to educate impacted residents and enable their participation in efforts to get a nearby contaminated waste site remediated. Community members were active participants in the development of the plan to clean up the toxic site. These methods can be used to better engage the community in research and involve them in actions taken to improve their neighborhood

Rotaxane liquid crystals with variable length: The effect of switching efficiency on the isotropic-nematic transition

We examine a solution of non-adaptive two-state rotaxane molecules which can switch from a short state of length L to a long state of length qL, using statistical thermodynamics. This molecular switching is externally driven and can result in an isotropic-nematic phase transition without altering temperature and concentration. Here we concentrate on the limitation imposed by switching inefficiency, i.e., on the case where molecular switching is not quantitative, leading to a solution of rotaxanes in different states. We present switching diagrams that can guide in the design of rotaxanes which affect a macroscopic phase change

Using photovoice as a tool for community engagement to assess the environment and explore environmental health disparities

Photovoice was used as a participatory research method to document perceived local environmental hazards, pollution sources, and potential impact on health among community members to address environmental health disparities. A convenience sample of 16 adults in Orangeburg, South Carolina participated in Photovoice. Photos depicted positive and negative implications of the environment across seven themes: recreation and leisure; food access; hazards and pollution; health, human, and social services; economic issues; beautification; and accommodation and accessibility. Positive and negative photos demonstrated a high level of interest among community members in considering how the environment influences health and health disparities