Analysis of pilot data assessing vaccine hesitancy in an urban clinic setting

Widespread use of childhood vaccination has significantly reduced the burden of childhood disease, however a subset of parents are choosing to delay or refuse available vaccines. This study analyzed data collected from a large surveillance study to examine the parents’ attitudes about vaccines and the prevalence of vaccine hesitancy (vaccine delay and refusal) in an urban clinic population. The parents of 961 children attending the Boston Medical Center Pediatrics department participated in the study. Parental responses to four vaccine questions were used to assess vaccine attitudes. Log-Binomial Regression models were used to evaluate the relationship between comorbidity status and birth order with vaccine delay or refusal. In this study population, parents reported generally positive attitudes toward vaccination. The majority (87%) believed that vaccines were necessary to protect their child. Approximately 16% of parents reported that had delayed or refused a vaccine and 24% of parents indicated that they did not believe or were unsure if other parents vaccinating their children. When asked the reason for their choice, parents who only delayed frequently cited logistic concerns like a missed appointment, whereas parents who refused more often cited personal beliefs, such as concerns that their child could become ill from vaccination. Finally, parents of children with a comorbidity were more likely to refuse a vaccine than parents of children without comorbidity (Adjusted RR=1.8, 95% CI: 1.1, 2.9). While parents were generally positive toward vaccines, for the small portion of parents refusing vaccines, further work could help to better explain their motivations

Mobile Apps Catalog

The Mobile Apps Catalog is a collection of emergency management and assistive mobile applications intended to assist first responders, emergency managers, and the public, specifically people with disabilities or others with access and function needs. Highlighted in this catalog are readily available preparedness and response apps that can be accessed by wireless devices, as well as assistive resources to advance the usability of wireless devices for consumers with disabilities. The apps are also helpful for the whole community. “Federal Emergency Management Agency (FEMA)’s “Whole Community” approach to emergency management recognizes that individuals, families and communities are assets and keys to success (Fugate 2011).

Vegetation structure and biodiversity recovery in 19-year-old active restoration plantations in a Neotropical cloud forest

Aim of the study: To evaluate how middle-aged active restoration plantations of native tree species contribute to the recovery of the tropical cloud forest in terms of vegetation structure, tree richness, species composition, and to shade-tolerance and seed dispersal mode functional groups.Area of the study: We studied two 19-year-old active restoration sites and their reference mature forests in the tropical montane cloud forest belt, Veracruz, Mexico.Materials and methods: The basal area, density and height as well as the tree species composition and number of species and individuals classified by shade tolerance (pioneer and non-pioneer trees), and seed dispersal mode (anemochorous, barochorous-synzoochorous and endozoochorous) were compared between active restoration plantations and reference forests.Main results: Planted trees and the woody vegetation growing under them represented a high proportion of reference forests’ basal area. Tree richness and Shannon’s equitability index were similar in both reference forests and one active restoration plantation and slightly different in the other. Tree species composition differed among sites; however, each 19-year-old plantation already had several non-pioneer species and a similar species proportion of the seed dispersal syndromes present in their reference forests.Research highlights: Active restoration accelerated the recovery of cloud forest in degraded pasture and bracken fern lands. Planted trees promoted the rapid development of vegetation structure and natural tree regeneration. Although species composition is still different, these middle-aged restoration plantations already have forest species and a proportion of functional groups of species similar to those of their own reference montane cloud forests.Keywords: active restoration; forest recovery; passive restoration; seed dispersal mode; succession; tree species; tropical montane cloud forest

Service Provider Views of Oxycontin Use on an Indian Reservation: Traumatic Effects on the Tribal Community

This is the publisher's version, also available electronically from http://alliance1.metapress.com/home/main.mpx.This qualitative research study on a Great Lakes Indian reservation used semistructured interviews of American Indian (n = 8) and non-American Indian (n = 2) providers of behavioral and physical health services to elicit views of Oxycontin use. We gathered data on existing substance abuse services including accessibility, cultural appropriateness, service strengths and weaknesses, barriers to treatment, and treatment needs. Results indicated a high prevalence of the use of Oxycontin, with traumatic effects on families and the tribal community such that the providers were overburdened with their dual role as service providers and caretakers in their own community. Implications for social work practice are discussed

Iwi cultural identity: The praxis of tūpuna narrative

This research is a narrative-based study of tūpuna narrative practices. As a privileged medium tūpuna narratives construct the conditions of iwi praxis which leads to mana-motuhake: the political independence and self-determination of Māori. This study explores how the Ngāti Koi applied ‘tūpuna narratives’ to challenge the hegemonic identity imposed on them that effectively alienated and silenced them erasing their memories of who they were and are. It is an auto-ethnography of an iwi, a whānau, a family it is a story about the writer. While this may seem a personal objective, the result indicates a cultural problematic in that the search for identity involves a critical kaupapa Māori investigation for an iwi to make sense of the act of colonisation, the colonial institutions that named them and the revitalization of their iwi identity in a Treaty of Waitangi context. This study has found that ‘tūpuna narratives’ represent identity conceptions that have implications for traditional normative practices. In narrative study there are no prescribed means for unearthing and creating meanings, research methods take the form of co-construction, the emphasis is on doing what is necessary to capture the lived experiences of iwi in terms of their particular-and-unique circumstances. Over time dominant theories have tended to align narrative practices with journalism, storytelling, myth and legend, tale and fable diminishing its conceptual role as the ‘epistemological other’ of the social sciences. The findings of this research illustrate the significant limitations of these theories. Narrative research is considered both a research method ‘in itself’ and also the phenomenon under study. In this study, narrative is applied as a conceptual metaphor to create interpreted descriptions, to understand and link causal historical and personal events to colonial institutional decision-making. Placed within the conceptual constellation of Kaupapa Māori narrative methodology becomes a powerful tool for change: creating the conditions of iwi praxis which is the making, the transformation and revitalisation of iwi cultural identity. As I write Hauraki enters a Treaty of Waitangi ‘settled world’ the settlement formulae premised on the falsified stories begat by nineteenth-century institutional decision-makers. These stories have created a legacy of unease as open inter iwi hostilities are unleashed. Treaty settlements should result in rangimarie-peace, justice and praxis for iwi both internal to, and external of its polity and cultural borders. Clearly, they do not and the need for tūpuna narratives, free of colonial-institutional storying, remains

Body mass index and measures of body fat for defining obesity and underweight: a cross-sectional, population-based study

BACKGROUND: The body mass index (BMI) is commonly used as a surrogate marker for adiposity. However, the BMI indicates weight-for-height without considering differences in body composition and the contribution of body fat to overall body weight. The aim of this cross-sectional study was to identify sex-and-age-specific values for percentage body fat (%BF), measured using whole body dual energy x-ray absorptiometry (DXA), that correspond to BMI 18.5 kg/m(2) (threshold for underweight), 25.0 kg/m(2) (overweight) and 30.0 kg/m(2) (obesity) and compare the prevalence of underweight, overweight and obesity in the adult white Australian population using these BMI thresholds and equivalent values for %BF. These analyses utilise data from randomly-selected men (n = 1446) and women (n = 1045), age 20-96 years, who had concurrent anthropometry and DXA assessments as part of the Geelong Osteoporosis Study, 2001-2008. RESULTS: Values for %BF cut-points for underweight, overweight and obesity were predicted from sex, age and BMI. Using these cut-points, the age-standardised prevalence among men for underweight was 3.1% (95% CI 2.1, 4.1), overweight 40.4% (95% CI 37.7, 43.1) and obesity 24.7% (95% CI 22.2, 27.1); among women, prevalence for underweight was 3.8% (95% CI 2.6, 5.0), overweight 32.3% (95% CI 29.5, 35.2) and obesity 29.5% (95% CI 26.7, 32.3). Prevalence estimates using BMI criteria for men were: underweight 0.6% (95% CI 0.2, 1.1), overweight 45.5% (95% CI 42.7, 48.2) and obesity 19.7% (95% CI 17.5, 21.9); and for women, underweight 1.4% (95% CI 0.7, 2.0), overweight 30.3% (95% CI 27.5, 33.1) and obesity 28.2% (95% CI 25.4, 31.0). CONCLUSIONS: Utilising a single BMI threshold may underestimate the true extent of obesity in the white population, particularly among men. Similarly, the BMI underestimates the prevalence of underweight, suggesting that this body build is apparent in the population, albeit at a low prevalence. Optimal thresholds for defining underweight and obesity will ultimately depend on risk assessment for impaired health and early mortality

Chronic brain stimulation using Micro-ECoG devices

Recording and stimulating brain activity has had great success both as a research tool and as a clinical technique. Neural prosthetics can replace limbs, restore hearing, and treat disorders like Parkinson’s and epilepsy, but are relatively crude. Current neural prosthetic systems use penetrating electrodes to achieve high precision, but the invasive nature of these devices provoke a strong immune response that limits chronic use. (Polikov et al) In our study we evaluate micro-electrocortiographic (micro-ECoG) devices which sit under the skull and on the surface of the brain for stimulation over chronic timescales. We anticipate these devices with their less invasive placement will evoke less extreme immune responses compared to penetrating electrodes and allow for stable stimulation over long periods of time (months to years). These devices were developed by the NITRO Lab of University of Wisconsin. (Thongpang et al) In short, Sprague Dawley rats were implanted with micro-ECoG devices over either somatosensory or auditor cortex. They were stimulated electrically through these devices on a daily basis to evaluate their chronic performance in vivo. Sensitivity to stimulation was determined via an operant behavioral task and the implants’ electrical properties were measured daily to monitor functionality and approximate of the immune response. After at least two months of implantation, animals were perfused and a histological analysis was performed to evaluate the chronic immune response. From preliminary results we expect to see that the micro-ECoG devices are capable of long term stimulation and evoke a smaller immune response from the brain than penetrating neural implants. In addition, we have found that removing the dura in rats for device implantation causes significant brain swelling, which indicates a strong immune response preventing effective stimulation. This research shows that micro-ECoG devices can chronically stimulate brain tissue and show great promise as a less invasive method of neural interfacing compared to traditional penetrating electrodes

A Differential Deficit in Time- Versus Event-Based Prospective Memory in Parkinson\u27s Disease

Objective: The aim of the current study was to clarify the nature and extent of impairment in time- versusevent-based prospective memory in Parkinson’s disease (PD). Prospective memory is thought to involvecognitive processes that are mediated by prefrontal systems and are executive in nature. Given thatindividuals with PD frequently show executive dysfunction, it is important to determine whether theseindividuals may have deficits in prospective memory that could impact daily functions, such as takingmedications. Although it has been reported that individuals with PD evidence impairment in prospectivememory, it is still unclear whether they show a greater deficit for time- versus event-based cues. Method:Fifty-four individuals with PD and 34 demographically similar healthy adults were administered astandardized measure of prospective memory that allows for a direct comparison of time-based andevent-based cues. In addition, participants were administered a series of standardized measures ofretrospective memory and executive functions. Results: Individuals with PD demonstrated impairedprospective memory performance compared to the healthy adults, with a greater impairment demonstratedfor the time-based tasks. Time-based prospective memory performance was moderately correlatedwith measures of executive functioning, but only the Stroop Neuropsychological Screening Test emergedas a unique predictor in a linear regression. Conclusions: Findings are interpreted within the context ofMcDaniel and Einstein’s (2000) multiprocess theory to suggest that individuals with PD experienceparticular difficulty executing a future intention when the cue to execute the prescribed intention requireshigher levels of executive control

Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families

UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5\u27-triphosphates (5\u27-ppp) on the genome of viral RNA. However, recent studies reported relatively low binding affinities of IFIT1 for 5\u27-ppp RNA, suggesting that IFIT1 may not interact efficiently with this moiety under physiological conditions. To evaluate the ability of IFIT1 to have an impact on negative-sense RNA viruses, we infected Ifit1(-/-) and wild-type control mice and primary cells with four negative-sense RNA viruses (influenza A virus [IAV], La Crosse virus [LACV], Oropouche virus [OROV], and Ebola virus) corresponding to three distinct families. Unexpectedly, a lack of Ifit1 gene expression did not result in increased infection by any of these viruses in cell culture. Analogously, morbidity, mortality, and viral burdens in tissues were identical between Ifit1(-/-) and control mice after infection with IAV, LACV, or OROV. Finally, deletion of the human IFIT1 protein in A549 cells did not affect IAV replication or infection, and reciprocally, ectopic expression of IFIT1 in HEK293T cells did not inhibit IAV infection. To explain the lack of antiviral activity against IAV, we measured the binding affinity of IFIT1 for RNA oligonucleotides resembling the 5\u27 ends of IAV gene segments. The affinity for 5\u27-ppp RNA was approximately 10-fold lower than that for non-2\u27-O-methylated (cap 0) RNA oligonucleotides. Based on this analysis, we conclude that IFIT1 is not a dominant restriction factor against negative-sense RNA viruses. IMPORTANCE: Negative-sense RNA viruses, including influenza virus and Ebola virus, have been responsible for some of the most deadly outbreaks in recent history. The host interferon response and induction of antiviral genes contribute to the control of infections by these viruses. IFIT1 is highly induced after virus infection and reportedly has antiviral activity against several RNA and DNA viruses. However, its role in restricting infection by negative-sense RNA viruses remains unclear. In this study, we evaluated the ability of IFIT1 to inhibit negative-sense RNA virus replication and pathogenesis both in vitro and in vivo. Detailed cell culture and animal studies demonstrated that IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses