244 research outputs found

    SAFEGUARDING THE FUTURE OF HOMELAND SECURITY

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    Homeland security is both a complex and a dynamic field, which involves a wide-variety of professions and information technology skill sets. Information security remains a primary concern for the National Security Agency (NSA) and the Department of Homeland Security. Continued challenges to the confidentiality, integrity, and availability of distributed computing drove the innovation of a new concentration in Homeland Security within the B.S. in Information Technology program at Middle Georgia State College. This paper will present the educational components of the Homeland Security concentration as well as discuss modifications to the Information Security and Assurance program. The programs design takes into account the outcomes from the Center of Excellence in Information Assurance Education (CAE) with the intent of moving the institution into a recognized status

    AVOIDING DISASTER IN ONSITE INCIDENT RESPONSE PLANNING: A CASE STUDY

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    An effective security policy is a detrimental part of any organization’s sustainability, and can mean the difference between success and failure for the organization should a disaster occur. The main components of the security policy are the incidence response plan and the disaster recovery plan. Many organizations, however, do not know how to go about incorporating these plans into their policies and standards. The workshop discusses best practices in gathering requirements for the development of Incident Response Planning, paying particular attention to issues that are unique in an online learning system. An actual organization in need of these plans was selected and participated in this study. Issues to discuss include physical walkthroughs of facilities, obtaining knowledge of the procedures and policies already in place at organizations, methods of interviewing key people in the organization, analyzing the organization’s strengths and weaknesses as they relate to physical and logical security, and legal requirements that should be followed. With this information, the workshop will then demonstrate how to devise a comprehensive plan to assist an organization in meeting minimum-security standards through implementation of best practices as outlined by the National Institute of Science and Technology (NIST)

    The Building Blocks for JWST I and T (Integrations and Test) to Operations - From Simulator to Flight Units

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    The James Webb Space Telescope (JWST) Project has an extended integration and test (I&T) phase due to long procurement and development times of various components as well as recent launch delays. The JWST Ground Segment and Operations group has developed a roadmap of the various ground and flight elements and their use in the various JWST I&T test programs. The JWST Project s building block approach to the eventual operational systems, while not new, is complex and challenging; a large-scale mission like JWST involves international partners, many vendors across the United States, and competing needs for the same systems. One of the challenges is resource balancing so simulators and flight products for various elements congeal into integrated systems used for I&T and flight operations activities. This building block approach to an incremental buildup provides for early problem identification with simulators and exercises the flight operations systems, products, and interfaces during the JWST I&T test programs. The JWST Project has completed some early I&T with the simulators, engineering models and some components of the operational ground system. The JWST Project is testing the various flight units as they are delivered and will continue to do so for the entire flight and operational system. The JWST Project has already and will continue to reap the value of the building block approach on the road to launch and flight operations

    Integrative Discovery of Epigenetically Derepressed Cancer Testis Antigens in NSCLC

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    Background: Cancer/testis antigens (CTAs) were first discovered as immunogenic targets normally expressed in germline cells, but differentially expressed in a variety of human cancers. In this study, we used an integrative epigenetic screening approach to identify coordinately expressed genes in human non-small cell lung cancer (NSCLC) whose transcription is driven by promoter demethylation. Methodology/Principal Findings: Our screening approach found 290 significant genes from the over 47,000 transcripts incorporated in the Affymetrix Human Genome U133 Plus 2.0 expression array. Of the top 55 candidates, 10 showed both differential overexpression and promoter region hypomethylation in NSCLC. Surprisingly, 6 of the 10 genes discovered by this approach were CTAs. Using a separate cohort of primary tumor and normal tissue, we validated NSCLC promoter hypomethylation and increased expression by quantitative RT-PCR for all 10 genes. We noted significant, coordinated coexpression of multiple target genes, as well as coordinated promoter demethylation, in a large set of individual tumors that was associated with the SCC subtype of NSCLC. In addition, we identified 2 novel target genes that exhibited growth- promoting effects in multiple cell lines. Conclusions/Significance: Coordinated promoter demethylation in NSCLC is associated with aberrant expression of CTAs and potential, novel candidate protooncogenes that can be identified using integrative discovery techniques. These findings have significant implications for discovery of novel CTAs and CT antigen directed immunotherapy. © 2009 Glazer et al
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