Methods for Estimating the Critical Shear Stress of Individual of Individual Fractions in Mixed-Size Sediment

Two methods are commonly used to estimate the critical shear stress of individual fractions in mixed-size sediment, one using the largest grain displaced, the other using the shear stress that produces a small value of transport rate for each fraction. The initial-motion results produced by the two methods are typically different: largest-grain critical shear stresses vary with roughly the square root of grain size, and reference transport critical shear stresses show little variation with grain size. Comparison of the two methods is seldom possible because both methods can rarely be applied to the same data. The one case known for which both methods can be used suggests that the typical differences in initial-motion results reflect more methodological influence than real differences in the initial motion of different sediments. Although the two classes of methods may not be directly compared, a general definition of initial-motion in mixed-size sediment is presented that allows the characteristic differences between the results to be explained in terms of sampling and scaling considerations inherent in the mixed-size initial-motion problem. The initial-motion criterion defined also provides a rational basis for collecting comparable and reproducible data using the two classes of method

Effects of Land Use Change on Channel Morphology in Northeastern Puerto Rico

Between 1830 and 1950 much of northeastern Puerto Rico was cleared for agriculture. Runoff increased by 50% and sediment supply to the river channels increased by more than an order of magnitude. Much of the land clearance extended to steep valley slopes, resulting in widespread gullying and landslides and a large load of coarse sediments delivered to the stream channels. A shift from agriculture to industrial and residential land uses over the past 50 yr has maintained the elevated runoff while sediment supply has decreased, allowing the rivers to begin removing coarse sediment stored within their channels. The size, abundance, and stratigraphic elevation of in-channel gravel bar deposits increases, channel depth decreases, and the frequency of overbank flooding increases downstream along these channels. This is presumed to be a transient state and continued transport will lead to degradation of the bed in downstream sections as the channel adjusts to the modern supply of water and sediment. A downstream decrease in channel size is contrary to the expected geometry of self-adjusted channels, but is consistent with the presence of partially evacuated sediment remaining from the earlier agricultural period. Reverse (downstream decreasing) channel morphology is not often cited in the literature, although consistent observations are available from areas with similar land-use history. Identification of reverse channel morphology along individual watercourses may be obscured in multiwatershed compilations in which other factors produce a consistent, but scattered downstream trend. Identification of reverse channel morphology along individual streams in areas with similar land-use history would be useful for identifying channel disequilibrium and anticipating future channel adjustments

Persistence of Armor Layers in Gravel-Bed Streams

Streambed surfaces are typically coarsened, or armored, at low flows, but there is little evidence of their condition during floods, when significant hydraulic and ecologic disturbance occurs. Some flume experiments have been used to conclude that armor layers wash out during floods, although other experiments have produced a persistent armor layer. In the absence of clear field or flume evidence, we use a surface-based transport model in an inverse prediction of surface grain size as a function of transport rates observed in the field. The predicted surface grain size matches that observed at low flow and indicates that low-flow armor layers persist at large flows. In the field, transport grain size increases with transport rate, reducing or eliminating adjustments in bed surface grain size as flow and transport increase. A persistent armor layer considerably simplifies the prediction of sediment transport, hydraulic roughness, and habitat disturbance during floods

The Flushing Flow Problem: Defining and Evaluating Objectives

Reservoir releases may be specified for the purpose of maintaining or improving the downstream channel and habitat. A wide variety of ecological or management objectives may be defined for such flushing flows (which may be broadly divided into sediment maintenance and channel maintenance flows). To specify a particular discharge and water volume for a flushing flow requires that the ecological or management objectives be translated into specific physical objectives for which flows can be specified. Flushing objectives that cannot be translated into definable flows are of little practical use, regardless of their intrinsic importance. Once defined, flushing flow objectives may be shown to conflict in some cases. For example, no flushing flow can satisfy the typical sediment maintenance objectives of maximizing sand removal and minimizing gravel loss. A discharge that mobilizes sediment throughout the channel cross section for channel maintenance purposes will often produce comparable transport rates of sand and gravel, thereby eliminating the selective transport of sand needed to reduce the sand content in the bed. Some nonflushing alternatives, such as artificial gravel replenishment and pool dredging, can be used to improve the performance of flushing flows. Selection among these alternatives and specification of a flushing flow discharge and volume depend directly on quantitative estimates of sand and gravel transport as a function of flow rate and volume

Experimental Study of the Transport of Mixed Sand and Gravel

We measured a wide range of transport rates for five different sand/gravel mixtures in a laboratory flume. Each mixture used the same gravel, and sand was added to produce mixtures containing 6, 15, 21, 27, and 34% sand. Control of other variables allows us to isolate the effect of bed sand content on transport. As sand content increases, gravel transport rates increase by orders of magnitude, even though the proportion of gravel in the bed decreases. The increase in gravel transport rate is most rapid over the range of bed sand content between 15 and 27%. The increase in transport rate is larger than predicted using standard scaling relations between transport rate and grain size, indicating that models of transport and sorting and predictions of stream channel response to sand inputs need to be revised to account for the influence of sand content. Bed surface grain size was measured at the end of each run. Surface grain size varied with sand content but showed little or no coarsening with flow strength and transport rate. This casts doubt on the idea that armor layers form at small flows and weaken or vanish with increasing flow and transport rate

Closing a Sediment Budget for a Reconfigured Reach of the Provo River, Utah

We quantified all components of a fluvial sediment budget for a discrete flood on an aggrading gravel bed river. Bed load transport rates were measured at the upstream and downstream ends of a 4 km study area on the Provo River, Utah, during a dam-controlled flood. We also collected high-resolution measurements of channel topography before and after the controlled flood for the entire reach. Topographic uncertainty in the digital elevation models (DEM) was characterized using a spatially variable approach. The net sediment flux provided unambiguous indication of storage. Sediment input to the reach (319 m3) exceeded output (32 m3), producing a net accumulation of approximately 290 m3. The difference between the scour and fill was also positive (470 m3), but uncertainty in the topographic differencing was larger than the observed net storage. Thus, the budget would have been indeterminate if based on morphologic data alone. Although topographic differencing was not sufficiently accurate to indicate net storage, it was able to demonstrate that internal erosion was a larger sediment source than the net sediment flux. The magnitude of total erosion (1454 m3) and deposition (1926 m3) was considerably larger than net change in storage, showing that internal sources and sinks were the dominant driver of channel change. The findings provide guidance for the development of sediment budgets in settings in which one must choose between a morphological approach and the direct measurement of sediment flux

Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer's disease: the MADE Phase II, three-arm RCT

Background: Minocycline is an anti-inflammatory drug and protects against the toxic effects of β-amyloid in vitro and in animal models of Alzheimer’s disease. To the best of our knowledge, no randomised placebo-controlled clinical trials in patients with Alzheimer’s disease looking at the efficacy and tolerability of minocycline have been carried out. Objectives: The trial investigated whether or not minocycline was superior to placebo in slowing down the rate of decline in cognitive and functional ability over 2 years. The safety and tolerability of minocycline were also assessed. Design: A Phase II, three-arm, randomised, double-blind, multicentre trial with a semifactorial design. Participants continued on trial treatment for up to 24 months. Setting: Patients were identified from memory services, both within the 32 participating NHS trusts and within the network of memory services supported by the Dementias and Neurodegenerative Diseases Research Network (also known as DeNDRoN). Participants: Patients with standardised Mini Mental State Examination scores of > 23 points and with Alzheimer’s disease assessed by the National Institute on Aging–Alzheimer’s Association’s criteria were identified from memory services. Intervention: Patients with mild Alzheimer’s disease were randomly allocated 1 : 1 : 1 to receive one of three treatments: arm 1 – 400 mg per day of minocycline; arm 2 – 200 mg per day of minocycline; or arm 3 – placebo. Patients continued treatment for 24 months. Participants, investigators and outcome assessors were blind to treatment allocation. Main outcome measures: Primary outcome measures were decline in standardised Mini Mental State Examination and Bristol Activities of Daily Living Scale scores of combined minocycline treatment arms versus placebo, as analysed by intention-to-treat repeated measures regression. Results: Between 23 May 2014 and 14 April 2016, 554 participants were randomised. Of the 544 eligible participants, the mean age was 74.3 years and the average standardised Mini Mental State Examination score was 26.4 points. A total of 252 serious adverse events were reported, with the most common categories being neuropsychiatric and cardiocirculatory. Significantly fewer participants completed treatment with 400 mg of minocycline [29% (53/184)] than 200 mg [62% (112/181)] or placebo [64% (114/179)] (p < 0.0001), mainly because of gastrointestinal symptoms (p = 0.0008), dermatological side effects (p = 0.02) and dizziness (p = 0.01). Assessment rates were also lower in the 400-mg treatment arm: 68% (119 of 174 expected) for standardised Mini Mental State Examination scores at 24 months, compared with 82% (144/176) for the 200-mg treatment arm and 84% (140/167) for the placebo arm. Decline in standardised Mini Mental State Examination scores over the 24-month study period in the combined minocycline arms was similar to that in the placebo arm (4.1- vs. 4.3-point reduction; p = 0.9), as was the decline in the 400- and 200-mg treatment arms (3.3 vs. 4.7 points; p = 0.08). Likewise, worsening of Bristol Activities of Daily Living Scale scores over 24 months was similar in all trial arms (5.7, 6.6 and 6.2 points in the 400-mg treatment arm, 200-mg treatment arm and placebo arm, respectively; a p-value of 0.57 for minocycline vs. placebo and a p-value of 0.77 for 400 vs. 200 mg of minocycline). Results were similar in different patient subgroups and in sensitivity analyses adjusting for missing data. Limitations: Potential limitations of the study include that biomarkers were not used to confirm the diagnosis of Alzheimer’s disease, as these and apolipoprotein E (APOE) genotyping are not routinely available within the NHS. Compliance was also worse than expected and differential follow-up rates were observed, with fewer assessments obtained for the 400-mg treatment arm than for the 200-mg treatment and placebo arms. Conclusions: Minocycline does not delay the progress of cognitive or functional impairment in people with mild Alzheimer’s disease over a 2-year period. Minocycline at a dose of 400 mg is poorly tolerated in this population. Future work: The Minocycline in mild Alzheimer’s DiseasE (MADE) study provides a framework for a streamlined trial design that can be usefully applied to test other disease-modifying therapies

StreamLab Collaboratory: Experiments, Data Sets, and Research Synthesis

A series of community-led, large-scale laboratory experiments, termed “StreamLab”, were performed by the National Center for Earth-surface Dynamics (NCED) with the purpose of advancing multidisciplinary research, education, and knowledge transfer at the interface of physical/chemical/biological processes in streams, science-based stream restoration practice, and environmental sensing technologies. Two series of experiments, StreamLab06 and StreamLab08, were conducted in the Main Channel of the St. Anthony Falls Laboratory at the University of Minnesota, a flume 84 m long and 2.75 m wide with water fed by the Mississippi River at a rate of up to 8.5 m3/s. The purpose of this paper is to share with the broader community the data collected with the hope of stimulating further analysis and future experimental campaigns toward advancing our predictive understanding of the physical, chemical, and biological processes in streams. Toward this end, a brief summary of the results to date is included and some ideas for further research are provided

The Cascadia Initiative : a sea change In seismological studies of subduction zones

Author Posting. © The Oceanography Society, 2014. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 27, no. 2 (2014): 138-150, doi:10.5670/oceanog.2014.49.Increasing public awareness that the Cascadia subduction zone in the Pacific Northwest is capable of great earthquakes (magnitude 9 and greater) motivates the Cascadia Initiative, an ambitious onshore/offshore seismic and geodetic experiment that takes advantage of an amphibious array to study questions ranging from megathrust earthquakes, to volcanic arc structure, to the formation, deformation and hydration of the Juan De Fuca and Gorda Plates. Here, we provide an overview of the Cascadia Initiative, including its primary science objectives, its experimental design and implementation, and a preview of how the resulting data are being used by a diverse and growing scientific community. The Cascadia Initiative also exemplifies how new technology and community-based experiments are opening up frontiers for marine science. The new technology—shielded ocean bottom seismometers—is allowing more routine investigation of the source zone of megathrust earthquakes, which almost exclusively lies offshore and in shallow water. The Cascadia Initiative offers opportunities and accompanying challenges to a rapidly expanding community of those who use ocean bottom seismic data.The Cascadia Initiative is supported by the National Science Foundation; the CIET is supported under grants OCE- 1139701, OCE-1238023, OCE‐1342503, OCE-1407821, and OCE-1427663 to the University of Oregon

Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β\u3csub\u3e1-42\u3c/sub\u3e and Hypertension

BACKGROUND: Alzheimer\u27s disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations and might be independently associated with these alterations in older adults. OBJECTIVE: To evaluate the independent and synergistic effects of HTN and AD pathology on WM alterations. METHODS: Clinical measures of cerebrovascular disease risk were collected from 62 participants in University of Kentucky Alzheimer\u27s Disease Center studies who also had cerebrospinal fluid (CSF) sampling and MRI brain scans. CSF Aβ1-42 levels were measured as a marker of AD, and fluid-attenuated inversion recovery imaging and diffusion tensor imaging were obtained to assess WM macro- and microstructural properties. Linear regression analyses were used to assess the relationships among WM alterations, cerebrovascular disease risk, and AD pathology. Voxelwise analyses were performed to examine spatial patterns of WM alteration associated with each pathology. RESULTS: HTN and CSF Aβ1-42 levels were each associated with white matter hyperintensities (WMH). Also, CSF Aβ1-42 levels were associated with alterations in normal appearing white matter fractional anisotropy (NAWM-FA), whereas HTN was marginally associated with alterations in NAWM-FA. Linear regression analyses demonstrated significant main effects of HTN and CSF Aβ1-42 on WMH volume, but no significant HTN×CSF Aβ1-42 interaction. Furthermore, voxelwise analyses showed unique patterns of WM alteration associated with hypertension and CSF Aβ1-42. CONCLUSION: Associations of HTN and lower CSF Aβ1-42 with WM alteration were statistically and spatially distinct, suggesting independent rather than synergistic effects. Considering such spatial distributions may improve diagnostic accuracy to address each underlying pathology