1,250 research outputs found

    Gender Differences in Relationships Between Personality and Career Attribute Priority

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    The relationship between personality and vocational choice have long been established. More recently, researchers have observed gender differences in some basic constructs of vocational attributes. In this study, we investigate the relationships between scores on a personality assessment instrument and relative priority ascribed to various career attributes in 790 subjects. Multivariate analysis confirmed significant relationships between personality factors and career attribute priority. Subsequent analysis performed on gender-based sample partitions showed notable distinctions in the specific relationships. The emerging personality-directed motivation traits and their gender distinctions may aid career counselors when advising clients regarding personality-based career decisions

    Daily Oral Language: Is It Effective?

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    This study examines the Daily Oral Language (DOL) program aimed at helping students learn mechanics of writing through daily editing exercises. This nine-month study sought to determine if DOL improved editing skills and actual writing skills of seventy fourth-grade students. While the results of this study did not statistically demonstrate the effectiveness of the DOL program, there were indications of improvement in children’s writing and editing skills. Recommendations for further investigation are provided

    Pinned Low Energy Electronic Excitation in Metal Exchanged Vanadium Oxide Nanoscrolls

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    We measured the optical properties of mixed valent vanadium oxide nanoscrolls and their metal exchanged derivatives in order to investigate the charge dynamics in these compounds. In contrast to the prediction of a metallic state for the metal exchanged derivatives within a rigid band model, we find that the injected charges in Mn2+^{2+} exchanged vanadium oxide nanoscrolls are pinned. A low-energy electronic excitation associated with the pinned carriers appears in the far infrared and persists at low temperature, suggesting that the nanoscrolls are weak metals in their bulk form, dominated by inhomogeneous charge disproportionation and Madelung energy effects.Comment: 4 figure

    Cervical radiograph of a patient with cervicogenic dizziness

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    Clinical image. This is a cervical X-ray of a patient suffering from long term dizziness and associated neck pain and stiffness.The X-ray showed that the C1 cervical vertebrae were in a rotated position.In some cases of dizziness, one of the causes can be attributed to pathology or dysfunction of upper cervical spine

    Ultracold collisions in tight harmonic traps: Quantum defect model and application to metastable helium atoms

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    We analyze a system of two colliding ultracold atoms under strong harmonic confinement from the viewpoint of quantum defect theory and formulate a generalized self-consistent method for determining the allowed energies. We also present two highly efficient computational methods for determining the bound state energies and eigenfunctions of such systems. The perturbed harmonic oscillator problem is characterized by a long asymptotic region beyond the effective range of the interatomic potential. The first method, which is based on quantum defect theory and is an adaptation of a technique developed by one of the authors (GP) for highly excited states in a modified Coulomb potential, is very efficient for integrating through this outer region. The second method is a direct numerical solution of the radial Schr\"{o}dinger equation using a discrete variable representation of the kinetic energy operator and a scaled radial coordinate grid. The methods are applied to the case of trapped spin-polarized metastable helium atoms. The calculated eigenvalues agree very closely for the two methods, and with those computed self-consistently using the generalized self-consistent method.Comment: 11 pages,REVTEX, text substantially revised, title modifie

    Test-Retest Reliability of Measuring the Vertebral Arterial Blood Flow Velocity in People With Cervicogenic Dizziness

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    Abstract OBJECTIVES: The purpose of this study was to determine the within-session and between-sessions reliability of measuring the vertebral artery blood flow velocities in people with cervicogenic dizziness using Doppler ultrasound at both upper and lower cervical levels. METHODS: Outcome measures were taken on 2 occasions 3 weeks apart with no active treatment provided in between the assessments on 12 participants. Pulsed-wave Doppler ultrasound was used to quantify time-averaged mean velocities through the vertebral artery at upper cervical (C0-1) and lower cervical vertebrae (C5-6). The clinical outcome measures were also recorded in people with cervicogenic dizziness. The intraclass correlation coefficient (ICC) was used to determine the within-session and between-session repeatability. Paired t test was used to determine the differences in the time-averaged mean velocities of blood flow at the same site of the vertebral artery and the clinical outcome measures in 2 sessions 3 weeks apart. RESULTS: In people with cervicogenic dizziness, there was no significant change in both clinical outcome measures and the time-averaged mean velocities when the patients were measured 3 weeks apart (P > .05). This study identified good within-session (ICC: 0.903-0.967) and between-session (ICC: 0.922-0.984) repeatability in measuring the vertical blood flow velocities in patients with cervicogenic dizziness when the clinical outcome measures were unchanged. CONCLUSIONS: This study supports the use of Doppler ultrasound to identify changes in mean vertebral arterial blood flow velocities before and after intervention in people with cervicogenic dizziness in future studies

    The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis

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    Rhodococcus equi (R. equi) is an important pulmonary pathogen in foals that often leads to the death of the horse. The bacterium harbors a virulence plasmid that encodes numerous virulence-associated proteins (Vaps) including VapA that is essential for intracellular survival inside macrophages. However, little is known about the precise function of VapA. Here, we demonstrate that VapA causes perturbation to late endocytic organelles with swollen endolysosome organelles having reduced Cathepsin B activity and an accumulation of LBPA, LC3 and Rab7. The data are indicative of a loss of endolysosomal function, which leads cells to upregulate lysosome biogenesis to compensate for the loss of functional endolysosomes. Although there is a high degree of homology of the core region of VapA to other Vap proteins, only the highly conserved core region of VapA, and not VapD of VapG, gives the observed effects on endolysosomes. This is the first demonstration of how VapA works and implies that VapA aids R. equi survival by reducing the impact of lysosomes on phagocytosed bacteria

    A framework for managing airport grasslands and birds amidst conflicting priorities

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    Management of modern airports is a task beset by conflicting priorities. Airports are vital to the global market economy, but impose costly environmental disturbances including habitat loss, noise, reduced air quality, erosion, introduction of invasive organisms, and polluted storm-water runoff (Blackwell et al. 2009). Airport environments also attract some wildlife hazardous to aviation safety, namely species involved in wildlife-aircraft collisions or ‘strikes’ (ICAO 2001, Blackwell et al. 2009, DeVault et al. 2011). Since 1912 at least 276 human lives have been lost due to bird strikes (Thorpe 2010), and from 1990 to 2010, more than 106 000 bird strikes involving civil aircraft were reported to the US Federal Aviation Administration (FAA; http://wildlife-mitigation. tc.faa.gov/wildlife/). Dolbeer (2006) reported that for strikes resulting in substantial aircraft damage (ICAO 1989), 66% occurred below 152 m altitude and within 1.5 km of a runway for airports servicing piston-powered aircraft only, and within 3 km of a runway for airports servicing turbine-powered aircraft (FAA 2009). Consequently, aviation authorities prioritize human safety over wildlife conservation in management of airport habitats (ICAO 2001, FAA 2009). Despite these problems, airports have been proposed as candidates for biodiversity conservation (Kelly & Allan 2006, Blackwell et al. 2009). For example, Kutschbach- Brohl et al. (2010) report that airport grasslands can provide habitat for a range of arthropod communities (e.g. Lepidoptera), and suggest the possibility of conserving these communities while minimizing provision of prey resources to birds recognized as hazardous to aviation. Moreover, declines in grassland bird populations in Europe and North America due to agricultural intensification and development have focused attention on enhancing quality and quantity of remnant grasslands (Herkert 1994, Vickery et al. 2004), including airport grasslands. In North America, airport properties have been identified as key areas of remnant grasslands important to obligate grassland bird species; species that both nest and forage in grasslands (Vickery et al. 1994, Askins et al. 2007). Airport properties in the contiguous USA include \u3e 330 000 ha of grassland, mostly annually mown areas, constituting 39–50% of airport property (DeVault et al. 2012). However, there is little research specific to airport environments that considers food resources for birds (Bernhardt et al. 2010, Kutschbach-Brohl et al. 2010), how birds perceive and react to predation risk (Baker & Brooks 1981) or disturbance (Kershner & Bollinger 1996), and no adequate assessment of how grassland management might affect strike risk (Blackwell et al. 2009, Martin et al. 2011). In this context, we contend that promoting conservation of obligate grassland birds and managing to reduce bird hazards to aviation safety combines two potentially conflicting objectives in a single management framework. Ecologically based guidance to solve this potential conflict is limited, if not oversimplified. Here, we question the potential use of airports to conserve grassland birds, and assess the challenges in managing airport grasslands in light of current ecological and behavioral frameworks. We consider conditions for conservation of obligate grassland birds on airports, and evidence on the use of airports by frequently struck, grassland birds (both obligate and facultative). We also provide a framework to manage grassland birds at airports, given current information and uncertainty. Because of the availability of strike data via the FAA, our focus is on North America. However, problems associated with bird use of airport grasslands are international (ICAO 2001). Therefore, our ultimate purpose is better to inform current management, but also identify research gaps and establish specific predictions that will guide future studies on the ecological basis of use of airport grasslands by birds

    Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile

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    CotE is a coat protein that is present in the spores of Clostridium difficile, an obligate anaerobic bacterium and a pathogen that is a leading cause of antibiotic-associated diarrhoea in hospital patients. Spores serve as the agents of disease transmission, and CotE has been implicated in their attachment to the gut epithelium and subsequent colonization of the host. CotE consists of an N-terminal peroxiredoxin domain and a C-terminal chitinase domain. Here, a C-terminal fragment of CotE comprising residues 349-712 has been crystallized and its structure has been determined to reveal a core eight-stranded β-barrel fold with a neighbouring subdomain containing a five-stranded β-sheet. A prominent groove running across the top of the barrel is lined by residues that are conserved in family 18 glycosyl hydrolases and which participate in catalysis. Electron density identified in the groove defines the pentapeptide Gly-Pro-Ala-Met-Lys derived from the N-terminus of the protein following proteolytic cleavage to remove an affinity-purification tag. These observations suggest the possibility of designing peptidomimetics to block C. difficile transmission
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