Upgrade of SULTAN/EDIPO for HTS Cable Test

AbstractCRPP hosts two unique conductor test facilities SULTAN (SUpraLeiter TestANlage) and EDIPO (European DIPOle). They allow the test of high current superconductors in high magnetic fields (SULTAN 11 T, EDIPO 12.5 T). In both facilities sample currents up to 100 kA can be supplied by means of a NbTi transformer. Presently the facilities are upgraded for the test of high current high-temperature superconductor (HTS) samples. For HTS conductor testing at temperatures between 20 and 50K, the heat flux between the HTS sample under test and the NbTi transformer needs to be limited to around 10W per conductor leg by means of an HTS adapter connecting them. The second required upgrade is the supply of intermediate temperature helium (20-50 K) to the HTS test conductor. It is mandatory that the helium gas coming from the HTS conductor under test can be returned to the cryoplant as cold gas (T < 20K). To reach this goal a tube-in-tube heat exchanger has been manufactured in which 4.5K helium coming from the cryoplant is in counter flow with the warm gas leaving the HTS test conductor

From Isotopes to TK Interviews: Towards Interdisciplinary Research in Fort Resolution and the Slave River Delta, Northwest Territories

Evolving research in Fort Resolution and the Slave River Delta, Northwest Territories, aims to improve understanding of how the natural ecosystem functions and responds to various environmental stressors, as well as to enhance the stewardship of natural resources and the capacity of local residents to respond to change. We seek to integrate approaches that span the natural and social sciences and traditional knowledge understandings of change, employing a research design developed in response to the concerns of a northern community. In doing so, we have strived for a research process that is collaborative, interdisciplinary, policy-oriented, and reflective of northern priorities. These elements characterize the new northern research paradigm increasingly promoted by various federal funding agencies, northern partners, and communities. They represent a holistic perspective in the pursuit of solutions to address complex environmental and socioeconomic concerns about impacts of climate change and resource development on northern societies. However, efforts to fulfill the objectives of this research paradigm are associated with a host of on-the-ground challenges. These challenges include (but are not restricted to) developing effective community partnerships and collaboration and documenting change through interdisciplinary approaches. Here we provide an overview of the components that comprise our interdisciplinary research program and offer an accounting of our formative experiences in confronting these challenges

Optimisation of ITER Nb3Sn CICCs for coupling loss, transverse electromagnetic load and axial thermal contraction

The ITER cable-in-conduit conductors (CICCs) are built up from sub-cable bundles, wound in different stages, which are twisted to counter coupling loss caused by time-changing external magnet fields. The selection of the twist pitch lengths has major implications for the performance of the cable in the case of strain sensitive superconductors, i.e. Nb3Sn, as the electromagnetic and thermal contraction loads are large but also for the heat load from the AC coupling loss. Reduction of the transverse load and warm-up cool-down degradation can be reached by applying longer twist pitches in a particular sequence for the sub-stages, offering a large cable transverse stiffness, adequate axial flexibility and maximum allowed lateral strand support. Analysis of short sample (TF conductor) data reveals that increasing the twist pitch can lead to a gain of the effective axial compressive strain of more than 0.3 % with practically no degradation from bending. For reduction of the coupling loss, specific choices of the cabling twist sequence are needed with the aim to minimize the area of linked strands and bundles that are coupled and form loops with the applied changing magnetic field, instead of simply avoiding longer pitches. In addition we recommend increasing the wrap coverage of the CS conductor from 50 % to at least 70 %. The models predict significant improvement against strain sensitivity and substantial decrease of the AC coupling loss in Nb3Sn CICCs, but also for NbTi CICCs minimization of the coupling loss can be achieved. Although the success of long pitches to transverse load degradation was already demonstrated, the prediction of the combination with low coupling loss needs to be validated by a short sample test.Comment: to be published in Supercond Sci Techno

Magnetization Reversal and Nanoscopic Magnetic Phase Separation in Doped La1-xSrxCoO3

The doped perovskite cobaltite La1-xSrxCoO3 (LSCO) has been advanced as a model system for studying intrinsic magnetic phase separation. We have employed a first-order reversal curve (FORC) method to probe the amount of irreversible switching in bulk polycrystalline LSCO as a function of Sr doping, field cooling procedure, and temperature. The value of the FORC distribution, rho, is used as a measure of the extent of irreversible switching. For x < 0.18, the small values of rho and its ridge-like distribution along local coercivity (Hc) and zero bias (Hb), are characteristic of non-interacting single domain particles. This is consistent with the formation of an array of isolated nanoscopic ferromagnetic clusters, as observed in previous work. For x >= 0.18, the much larger values of rho, the tilting of its distribution towards negative bias field, and the emergence of regions with negative rho, are consistent with increased long-range ferromagnetic ordering. The FORC distributions display little dependence on the cooling procedure. With increasing temperature, the fraction of irreversible switching determined from the FORC distribution follows closely the ferromagnetic phase fraction measured by La nuclear magnetic resonance. Our results furthermore demonstrate that the FORC method is a valuable first-pass characterization tool for magnetic phase separation.Comment: 30 pages, 8 figures, to appear in PR

Gladstone Harbour Fish Health Investigation 2011-2012

The Gladstone Harbour Fish Health Investigation occurred in response to public concerns regarding fish health in Gladstone Harbour, which were raised with the former Department of Employment, Economic Development and Innovation (now Department of Agriculture, Fisheries and Forestry (DAFF)) in August 2011. The majority of concerns were regarding skin redness, lesions and eye damage observed on barramundi caught from the Boyne River or within its vicinity. Further reports included unusual skin redness and occasional lesions observed on a range of fish species from Gladstone Harbour (including sharks), as well as an increase in the incidence of shell erosion on mud crabs. The subsequent investigation aimed to determine the cause of the reported issues and specifically to address public concern regarding the potential impact of industrial activity including dredging in Gladstone Harbour. The investigation, conducted by DAFF, was part of a whole-of-government response, which included sediment and water quality testing; and investigation into human health concerns. The first reports of abnormalities in fish were received months after a major flood event happened in Gladstone from December 2010 until early 2011. The flood event caused a dramatic influx of large barramundi (estimated 30 000), as well as other species from Lake Awoonga into the Boyne River when the Awoonga Dam spilled over. The dam had not spilled over since the 1990s, well before the dam wall was raised in 2002. Many of these fish were injured (some fatally) from the force of the impact when passing over the spillway. It is believed that a smaller number of fish were washed over during a second flood event in early 2012. The initial response investigated fish with visible abnormalities (e.g. missing scales and redness), and signs of disease to indicate the cause of the observed issues. This early sampling (Phase 1) between August 2011 and February 2012 was based on observations of commercial fishing activity, contracted fish surveys and submissions by members of the public. Over 5000 fish, crustaceans and molluscs were visually assessed during this sampling. In January 2012, the Independent Gladstone Fish Health Scientific Advisory Panel released a report recommending a structured sampling program to gauge fish health in Gladstone Harbour sites against comparable unaffected sites (reference sites), through time. It also recommended the development of a conceptual model of possible cause-effect relationships to help guide studies and eliminate potential causal factors. Structured sampling in Gladstone Harbour (Phase 2) was conducted in two major surveys during April–May (Trip 1) and June–July (Trip 2) 2012. These surveys covered 11 sites including two reference sites and focussed on a subset of 10 species. The selected species represented a range of different life cycles (e.g. catadromous and estuarine) and trophic levels (e.g. predatory, omnivorous detritivores and scavengers), and had been reported with a variety of abnormalities. A third targeted survey was conducted in September 2012 to monitor potential seasonal reoccurrence of parasitic infestations in the barramundi from the Boyne River. A total of 3699 fish and crustaceans were visually assessed in the field, with 452 specimens examined by necropsy, and tissues from 120 specimens subjected to histopathology and chemical residue testing

Disease prevention strategies for QX disease (Marteilia sydneyi) of Sydney rock oysters (Saccostrea glomerata)

The Sydney rock oyster (Saccostrea glomerata) forms the basis of an important aquaculture industry on the east coast of Australia. During the 1970s, production of S. glomerata began to decline, in part as a result of mortalities arising from Queensland unknown (QX) disease. Histological studies implicated the paramyxean parasite Marteilia sydneyi in the disease outbreaks. Disease zoning was implemented to prevent the spread of M. sydneyi-infected oysters. This control measure hindered rock oyster farming, which historically has relied on transferring wild-caught spat between estuaries for on-growing to market size and has not prevented the subsequent occurrence of QX disease in the Georges and Hawkesbury rivers in central New South Wales. Management of QX disease has been hampered by the complicated life cycle of M. sydneyi, with outbreaks of QX disease likely to be regulated by a combination of the abundance of intermediate host of M. sydneyi, environmental stressors, and the immunocompetence of S. glomerata. The future of the Sydney rock oyster industry relies on understanding these factors and progressing the industry from relying on farming wild-caught seed to the successful commercialization of hatchery-produced QX-resistant S. glomerata

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin

Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been presented that translocation of the enzymatic components of anthrax-toxin across the endosomal membrane of target cells and channel formation by the heptameric/octameric PA63 binding/translocation component are related phenomena. Chloroquine and some 4-aminoquinolones, known as potent drugs against Plasmodium falciparium infection of humans, block efficiently the PA63-channel in a dose dependent way.Methodology/Principal Findings:Here we demonstrate that related positively charged heterocyclic azolopyridinium salts block the PA63-channel in the μM range, when both, inhibitor and PA63 are added to the same side of the membrane, the cis-side, which corresponds to the lumen of acidified endosomal vesicles of target cells. Noise-analysis allowed the study of the kinetics of the plug formation by the heterocycles. In vivo experiments using J774A.1 macrophages demonstrated that the inhibitors of PA63-channel function also efficiently block intoxication of the cells by the combination lethal factor and PA63 in the same concentration range as they block the channels in vitro.Conclusions/Significance:These results strongly argue in favor of a transport of lethal factor through the PA63-channel and suggest that the heterocycles used in this study could represent attractive candidates for development of novel therapeutic strategies against anthrax. © 2013 Beitzinger et al

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

The E3 ubiquitin ligase Pellino can be activated by phosphorylation in vitro, catalyzed by IL-1 receptor-associated kinase 1 (IRAK1) or IRAK4. Here, we show that phosphorylation enhances the E3 ligase activity of Pellino 1 similarly with any of several E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b) and identify 7 amino acid residues in Pellino 1 whose phosphorylation is critical for activation. Five of these sites are clustered between residues 76 and 86 (Ser-76, Ser-78, Thr-80, Ser-82, and Thr-86) and decorate a region of antiparallel β-sheet, termed the “wing,” which is an appendage of the forkhead-associated domain that is thought to interact with IRAK1. The other 2 sites are located at Thr-288 and Ser-293, just N-terminal to the RING-like domain that carries the E3 ligase activity. Unusually, the full activation of Pellino 1 can be achieved by phosphorylating any one of several different sites (Ser-76, Thr-86, Thr-288, or Ser-293) or a combination of other sites (Ser-78, Thr-80, and Ser-82). These observations imply that dephosphorylation of multiple sites is required to inactivate Pellino 1, which could be a device for prolonging Pellino's E3 ubiquitin ligase activity in vivo