292 research outputs found

    Logical gaps in the approximate solutions of the social learning game and an exact solution

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    After the social learning models were proposed, finding the solutions of the games becomes a well-defined mathematical question. However, almost all papers on the games and their applications are based on solutions built upon either an add-hoc argument or a twisted Bayesian analysis of the games. Here, we present logical gaps in those solutions and an exact solution of our own. We also introduced a minor extension to the original game such that not only logical difference but also difference in action outcomes among those solutions become visible.Comment: A major revisio

    The influence of contact area between implant and its adjacent teeth on finite element analysis

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    The aim of this work is to investigate the influence of contact area between the first molar implant and its adjacent teeth on finite element analysis. Five types of finite element contact models containing implant and its adjacent teeth were established: non-contact model (C0), contact models with different contact area (C1, C2, C3, C4). An occlusal force was applied to finite element models to calculate the stress of implant and bone interface on mandible. Compared with the group C0, the stress of alveolar bone surrounding the implant in other groups decreased 88.08 % at most, but the stress of cancellous bone surrounding the natural teeth increased 59.42 %. In summary, a proper small contact area can not only reduce the stress concentration on the implant region, but also can avoid an excessive stress in the periodontal ligament and alveolar bone around the natural teeth. The finite element results revealed that it is effectively to distribute the load implant suffered, especially to reduce the stress generated by the lateral load when the first molar implant has a small contact with its adjacent teeth

    COVID‐19 in Tuberculosis patients: a report of three cases

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    The clinical features and treatment of pulmonary tuberculosis patients with COVID‐19 is unclear and understudied. Here, three pulmonary tuberculosis patients with COVID‐19 infection were prospectively followed from hospital admission to discharge. We provide information and experience with treatment of pulmonary tuberculosis cases with confirmed COVID‐19 infection

    Improvement of Sciatic Nerve Regeneration Using Laminin-Binding Human NGF-β

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    Sciatic nerve injuries often cause partial or total loss of motor, sensory and autonomic functions due to the axon discontinuity, degeneration, and eventual death which finally result in substantial functional loss and decreased quality of life. Nerve growth factor (NGF) plays a critical role in peripheral nerve regeneration. However, the lack of efficient NGF delivery approach limits its clinical applications. We reported here by fusing with the N-terminal domain of agrin (NtA), NGF-β could target to nerve cells and improve nerve regeneration. was also measured. Using the rat sciatic nerve crush injury model, the nerve repair and functional restoration by utilizing LBD-NGF were tested.. In the rat sciatic nerve crush injury model, we found that LBD-NGF could be retained and concentrated at the nerve injury sites to promote nerve repair and enhance functional restoration following nerve damages.Fused with NtA, NGF-β could bind to laminin specifically. Since laminin is the major component of nerve extracellular matrix, laminin binding NGF could target to nerve cells and improve the repair of peripheral nerve injuries

    The Impact of Self-Relevance on Preschool Children’s Sharing

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    This study was designed to investigate the impact of self-relevance between preschool children and recipients on children’s sharing behavior in dictator games using a forced-choice resource distribution paradigm. Experiment 1: A total of 75 children aged 3–6 years were evaluated in a first-party situation in which they were distributed as recipients and dictators and shared resources with distracting recipients with different extents of self-relevance under three different payoff structures, including non-costly, costly, and envy structures. Children could choose between a sharing option and a non-sharing option. The results showed that, in a first-party situation, children aged 3–6 years old typically share more resources with highly self-relevant recipients (friends) than with moderately self-relevant recipients (acquaintances) and lowly self-relevant recipients (strangers) and that they share more resources with moderately self-relevant recipients (acquaintances) than lowly self-relevant recipients (strangers). Experiment 2: A total of 62 children aged 3–6 years old were evaluated in a third-party situation in which they were distributed not as recipients but only dictators, making decisions between the options of sharing more or sharing less with distracting recipients who had different extents of self-relevance under three different payoff structures, such as non-bias, high self-bias, and low self-bias. The results showed that, in a third-party situation, children typically share in a similar manner to that of Experiment 1, meaning that children display selective generosity and that the self-relevance between the children and recipients played a key role. Across age groups, this study of preschool children (total N = 137) demonstrates a degree of effect of self-relevance on preschool children’s sharing in first-party and third-party situations, with highly self-relevant recipients receiving a more preferential share in the dictator game than those with low self-relevance, although this effect was stronger in the older preschool children

    The role of microbiota in the development and treatment of gastric cancer

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    The stomach was once considered a sterile organ until the discovery of Helicobacter pylori (HP). With the application of high-throughput sequencing technology and macrogenomics, researchers have identified fungi and fivemajor bacterial phyla within the stomachs of healthy individuals. These microbial communities exert regulatory influence over various physiological functions, including energy metabolism and immune responses. HP is a well-recognized risk factor for gastric cancer, significantly altering the stomach’s native microecology. Currently, numerous studies are centered on the mechanisms by which HP contributes to gastric cancer development, primarily involving the CagA oncoprotein. However, aside from exogenous infections such as HP and EBV, certain endogenous dysbiosis can also lead to gastric cancer through multiple mechanisms. Additionally, gut microbiota and its metabolites significantly impact the development of gastric cancer. The role of microbial therapies, including diet, phages, probiotics and fecal microbiota transplantation, in treating gastric cancer should not be underestimated. This review aims to study the mechanisms involved in the roles of exogenous pathogen infection and endogenous microbiota dysbiosis in the development of gastric cancer. Also, we describe the application of microbiota therapy in the treatment and prognosis of gastric cancer

    Temperature‐dependent mechanical and oxidation behavior of in situ formed ZrN/ZrO₂‐containing Si₃N₄‐based composite

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    In this work, Si₃N₄ and Zr(NO₃)₄ were used as raw materials to prepare ZrN/ZrO₂‐containing Si₃N₄‐based ceramic composite. The processing, phase composition, and microstructure of the composite were investigated. Hardness and fracture toughness of the ceramics were evaluated via Vickers indentation in Ar at 25°C, 300°C, 600°C, and 900°C. During spark plasma sintering, Zr(NO₃)₄ was transformed into tetragonal ZrO₂, which further reacted with Si₃N₄, resulting in the formation of ZrN. The introduction of ZrN enhanced the high‐temperature mechanical properties of the composite, and its hardness and fracture toughness reached 13.4 GPa and 6.1 MPa·m¹/² at 900°C, respectively. The oxidation experiment was carried out in air at 1000°C, 1300°C, and 1500°C for 5 h. It was shown that high‐temperature oxidation promoted the formation and growth of porous oxide layers. The microstructure and phase composition of the formed oxide layers were investigated in detail. Finally, it was identified that the obtained composite exhibited a higher thermal diffusivity than that of monolithic Si₃N₄ in the temperature range of 100°C–1000°C
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