Biography as Pedagogy: A Review of Hemingway’s Boat: Everything He Loved and Lost, 1934-1961

Hemingway’s Boat: Everything He Loved and Lost, 1934-1961 (2011) by Paul Hendrickson is an excellent example of a dual-purpose book for qualitative researchers. It firsts provides an example of high-quality scholarship in the field of life history research. It also offers the reader specific insights into the practice of qualitative research and how that data is used to create a narrative of the participant’s life. Through the use of authorial participation, a grounded narrative framework, and a detailed description of his research process, Hendrickson’s book is a keen exemplar of the process and product of qualitative work

Mapping of potential landslide areas in terms of slope stability

CER78-79DBS-RML-TJW19.Contract no. 16-712.O1-CA.Prepared for USDA Forest Service, Rocky Mountain Forest and Range Experiment Station.Includes bibliographical references (pages 57-62).November 1978

Simple procedural method for estimating on-site soil erosion

CER76-77DBS-RML-TJW38.Prepared for USDA Forest Service, Rocky Mountain Forest and Range Experiment Station.Includes bibliographical references (pages 37-38).February 1977

CLARIFY 2021: explanation and elaboration of the Delphi-based guidelines for the reporting of yoga research

Background: Reporting of yoga research often lacks the detail required for clinical application, study replication, summary research and comparative effectiveness studies. Methods: To improve the transparency of reporting yoga interventions, and building on the development of previous reporting guidelines, a group of international yoga research stakeholders developed the consensus-based CheckList stAndardising the Reporting of Interventions For Yoga (CLARIFY) guidelines. Results: The 21-item CLARIFY checklist outlines the minimum details considered necessary for high-quality reporting of yoga research. This paper provides a detailed explanation of each of the 21 items of the CLARIFY checklist, together with model examples of how to integrate each item into publications of yoga research. The CLARIFY guideline serves as an extension for existing research reporting guidelines, and is flexible for use across all study designs. Conclusion: We strongly encourage the uptake of these reporting guidelines by researchers and journals, to facilitate improvements in the transparency and utility of yoga research

Development of the CLARIFY (CheckList stAndardising the Reporting of Interventions For Yoga) guidelines: a Delphi study

Background: The use of yoga as a therapeutic modality is increasing; however, a lack of transparent intervention reporting is restricting the dissemination and implementation of yoga research into clinical and community practice. The aim of this study was to develop a yoga-specific reporting guideline as an extension to existing reporting guidelines for randomised controlled trials, observational studies and case reports. Methods: Recognised international stakeholders in the design and conduct of yoga research were invited to contribute to the electronic Delphi survey. A four-round Delphi was conducted, whereby panellists rated selected items for their importance in the inclusion of yoga reporting guidelines, according to a 5-step Likert scale. A priori consensus for item inclusion was agreement of items as ‘Very important’ or ‘Extremely important’ by ≥80% of panellists. Non-consensus items were forwarded to subsequent rounds for re-rating. Results: 53 experts in yoga research from 11 countries, primarily identifying as researchers (50%), allied health professionals (18.8%) and yoga professionals (12.5%), consented to participate in the Delphi. Of these, 48 completed Round 1 (91%), 43 completed Round 2 (81%), 39 completed Round 3 (74%) and 32 completed Round 4 (60%). Panellists reached consensus for inclusion on 21 items, grouped under 10 domains reflective of more generic intervention-based guidelines. Conclusions: The consensus-based 21-item CLARIFY (CheckList stAndardising the Reporting of Interventions For Yoga) checklist provides a minimum reporting template for researchers across a range of methodology designs. Use of these yoga-specific guidelines, in conjunction with the CLARIFY explanation and elaboration guidelines, will standardise the minimum level of detail required for transparent yoga intervention, facilitating the replication, dissemination and implementation of yoga research. Ongoing research will assess the uptake and impact of CLARIFY, to ensure these guidelines retain their relevance to the internationally growing field of yoga research

Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics

BACKGROUND: Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under conditions of induced stress. Since only the mutants, but not the endogenous wild-type FUS, are associated with stress granules under most of the stress conditions reported to date, the relationship between FUS and stress granules represents a mutant-specific phenotype and thus may be of significance in mutant-induced pathogenesis. While the association of mutant-FUS with stress granules is well established, the effect of the mutant protein on stress granules has not been examined. Here we investigated the effect of mutant-FUS on stress granule formation and dynamics under conditions of oxidative stress. RESULTS: We found that expression of mutant-FUS delays the assembly of stress granules. However, once stress granules containing mutant-FUS are formed, they are more dynamic, larger and more abundant compared to stress granules lacking FUS. Once stress is removed, stress granules disassemble more rapidly in cells expressing mutant-FUS. These effects directly correlate with the degree of mutant-FUS cytoplasmic localization, which is induced by mutations in the nuclear localization signal of the protein. We also determine that the RGG domains within FUS play a key role in its association to stress granules. While there has been speculation that arginine methylation within these RGG domains modulates the incorporation of FUS into stress granules, our results demonstrate that this post-translational modification is not involved. CONCLUSIONS: Our results indicate that mutant-FUS alters the dynamic properties of stress granules, which is consistent with a gain-of-toxic mechanism for mutant-FUS in stress granule assembly and cellular stress response

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors

Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) regulates the proliferation and differentiation of neuronal progenitor cells during brain development. Consequently, DYRK1A has attracted interest as a target for the treatment of neurodegenerative diseases, including Alzheimer's disease (AD) and Down's syndrome. Recently, the inhibition of DYRK1A has been investigated as a potential treatment for diabetes, while DYRK1A's role as a mediator in the cell cycle has garnered interest in oncologic indications. Structure-activity relationship (SAR) analysis in combination with high-resolution X-ray crystallography leads to a series of pyrazolo[1,5-b]pyridazine inhibitors with excellent ligand efficiencies, good physicochemical properties, and a high degree of selectivity over the kinome. Compound 11 exhibited good permeability and cellular activity without P-glycoprotein liability, extending the utility of 11 in an in vivo setting. These pyrazolo[1,5-b]pyridazines are a viable lead series in the discovery of new therapies for the treatment of diseases linked to DYRK1A function

The University of Iowa Biomass Energy Sustainability Index: A decision-making tool for the University of Iowa Biomass Partnership Project

Work continued on a plan to increase the renewable, sustainable fuel sources available to power operations at the University of Iowa in Iowa City. A team of researchers from multiple institutions collaborated to create a tool that would allow the UI to evaluate its alternative energy options more effectively

From problems in the North to the problematic North : Northern devolution through the lens of history

Current debates about Northern English cities and their role in national economic strategies cannot be read simply through the lens of contemporary politics. We therefore take the Northern Powerhouse as our starting point in a chapter which traces a long history of policy and planning discourses about the North of England. We use David Russell’s chronology of key historical moments in which Northern English cities hold a particular charge in cultural narratives of the nation to guide our analysis of contemporaneous tensions in debates about planning and governance. A focus on representations about the North of England over the course of the last two centuries reveals four interlocking themes: namely the role of London in directing debates about the North; a tension between political and spatial approaches to planning; the characterisation of cities in the North of England as intrinsically problematic places; and the continued issue of poverty in these cities