List Size, Standards and Perfromance in General Practice - A Pilot Study in the South East Thames Region

This is a report of a piolt study carried out among 155 general practitioner trainers in South East Thames region. Similar pilot studies have been carried out among trainers in four other regions on England. Separate reports have been prepared for each of the five regions, together with a summary report comparing the findings among the regions. The pilot studies were funded by the DHSS and carried out by staff of the Health Services Research Unit at the University of Kent at Camterbury

Southwest Research Institute assistance to NASA in biomedical areas of the technology utilization program Quarterly progress report, 1 May - 31 Jul. 1969

Dissemination of NASA derived technologies for biomedical applicatio

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian national breast screening study: randomised screening trial

Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available. Abstract Objective: To compare breast cancer incidence and mortality up to 25 years in women aged 40-59 who did or did not undergo mammography screening. Design: Follow-up of randomised screening trial by centre coordinators, the study’s central office, and linkage to cancer registries and vital statistics databases. Setting: 15 screening centres in six Canadian provinces,1980-85 (Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia). Participants: 89 835 women, aged 40-59, randomly assigned to mammography (five annual mammography screens) or control (no mammography). Interventions: Women aged 40-49 in the mammography arm and all women aged 50-59 in both arms received annual physical breast examinations. Women aged 40-49 in the control arm received a single examination followed by usual care in the community. Main outcome measure: Deaths from breast cancer. Results: During the five year screening period, 666 invasive breast cancers were diagnosed in the mammography arm (n=44 925 participants) and 524 in the controls (n=44 910), and of these, 180 women in the mammography arm and 171 women in the control arm died of breast cancer during the 25 year follow-up period. The overall hazard ratio for death from breast cancer diagnosed during the screening period associated with mammography was 1.05 (95% confidence interval 0.85 to 1.30). The findings for women aged 40-49 and 50-59 were almost identical. During the entire study period, 3250 women in the mammography arm and 3133 in the control arm had a diagnosis of breast cancer, and 500 and 505, respectively, died of breast cancer. Thus the cumulative mortality from breast cancer was similar between women in the mammography arm and in the control arm (hazard ratio 0.99, 95% confidence interval 0.88 to 1.12). After 15 years of follow-up a residual excess of 106 cancers was observed in the mammography arm, attributable to over-diagnosis. Conclusion: Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available. Overall, 22% (106/484) of screen detected invasive breast cancers were over-diagnosed, representing one over-diagnosed breast cancer for every 424 women who received mammography screening in the trial

The Discovery of Extended Thermal X-ray Emission from PKS 2152-699: Evidence for a `Jet-cloud' Interaction

A Chandra ACIS-S observation of PKS 2152-699 reveals thermal emission from a diffuse region around the core and a hotspot located 10" northeast from the core. This is the first detection of thermal X-ray radiation on kiloparsec scales from an extragalactic radio source. Two other hotspots located 47" north-northeast and 26" southwest from the core were also detected. Using a Raymond-Smith model, the first hotspot can be characterized with a thermal plasma temperature of 2.6$\times10^6$ K and an electron number density of 0.17 cm$^{-3}$. These values correspond to a cooling time of about 1.6$\times10^7$ yr. In addition, an emission line from the hotspot, possibly Fe xxv, was detected at rest wavelength 10.04\AA. The thermal X-ray emission from the first hotspot is offset from the radio emission but is coincident with optical filaments detected with broadband filters of HST/WFPC2. The best explanation for the X-ray, radio, and optical emission is that of a `jet-cloud' interaction. The diffuse emission around the nucleus of PKS 2152-699 can be modeled as a thermal plasma with a temperature of 1.2$\times10^7$ K and a luminosity of 1.8$\times10^{41}$ erg s$^{-1}$. This emission appears to be asymmetric with a small extension toward Hotspot A, similar to a jet. An optical hotspot (EELR) is seen less than an arcsecond away from this extension in the direction of the core. This indicates that the extension may be caused by the jet interacting with an inner ISM cloud, but entrainment of hot gas is unavoidable. Future observations are discussed.Comment: To appear in the Astrophysical Journal 21 pages, 5 Postscript figures, 1 table, AASTeX v. 5.

[OII] Emission, Eigenvector 1 and Orientation in Radio-quiet Quasars

We present supportive evidence that the Boroson and Green eigenvector 1 is not driven by source orientation. Until recently it was generally accepted that eigenvector 1 does not depend on orientation as it strongly correlates with [OIII]5007 emission, thought to be an isotropic property. However, recent studies of radio-loud AGN have questioned the isotropy of [OIII] emission and concluded that [OII]3727 emission is isotropic. In this paper we investigate the relation between eigenvector 1 and [OII] emission in radio-quiet BQS (Bright Quasar Survey) quasars, and readdress the issue of orientation as the driver of eigenvector 1. We find significant correlations between eigenvector 1 and orientation independent [OII] emission, which implies that orientation does not drive eigenvector 1. The luminosities and equivalent widths of [OIII] and [OII] correlate with one another, and the range in luminosities and equivalent widths is similar. This suggests that the radio-quiet BQS quasars are largely free of orientation dependent dust effects and ionization dependent effects in the narrow-line region. We also conclude that neither the [OIII] emission nor the [OII]/[OIII] ratio are dependent on orientation in our radio-quiet BQS quasar sample, contrary to recent results found for radio-loud quasars.Comment: 24 pages, 12 figures, accepted for publication in Ap

Southwest Research Institute assistance to NASA in biomedical areas of the technology utilization program Final report, 1 Feb. 1969 - 28 Feb. 1970

Technology utilization efforts by Biomedical Application Team member institut

Risk-based verification of large offshore systems

This paper begins with a very brief review of the current status of offshore safety with particular reference to the UK sector. The risk-based verification concept is then described. Following identification of the research needs, a general risk-based verification framework is proposed with appropriate risk assessment contents incorporated into it. An example is then followed to demonstrate the proposed framework. The Health, Environment and Safety Information System (THESIS) software package is also used to facilitate the implementation of the framework. Finally, both the benefits and the limitations of risk-based verification in offshore applications are highlighted. The emphasis of the paper is focused on industrial applications