The impact of a sport psychology education intervention on physiotherapists

The purpose of this study was to measure the impact of an online sport psychology education module on the attitudes and behaviours of qualified sports physiotherapists in the UK. Ninety-five sport physiotherapists studied either a sport psychology module or a control module, and their attitudes and behaviours towards sport psychology were measured prior to studying the module and at three points over a six-month period following its completion. It was found that those who had studied the sport psychology module demonstrated an improvement in their attitudes towards sport psychology immediately following its completion that was significantly higher than those who had studied the control module. Use of sport psychology also increased following the sport psychology module, with significant differences seen between the intervention and control group on the sport psychology subscale, indicating that those who had studied the sport psychology module were integrating more sport psychology techniques into their practice than those who had studied the control module. It was concluded that the online sport psychology module was effective in improving the attitudes and behaviours of UK physiotherapists and that more sport psychology education opportunities should be made available

Is there a link between previous exposure to sport injury psychology education and UK sport injury rehabilitation professionals' attitudes and behaviour towards sport psychology?

Objectives: The use of sport psychology strategies during sport injury rehabilitation can lead to several positive outcomes such as improved adherence and self-efficacy. The purpose of this study was to compare the sport psychology related attitudes and behaviours of UK sport injury rehabilitation professionals (SIRPs) who had studied the psychological aspects of sport injury to those who had not. Participants and design: Ninety-four SIRPs (54 physiotherapists and 40 sports therapists with a mean of 9.22 years' experience of working in sport) completed an online survey and were grouped according to their level of previous exposure to sport injury psychology education at an undergraduate/postgraduate level. Analyses were undertaken to establish whether there were any differences in sport psychology related attitude (MANOVA), usage (MANOVA), and referral behaviours (chi square) between the groups. Results: The MANOVA and chi square tests conducted revealed that those who had studied the psychological aspects of sport injury reported using significantly more sport psychology in their practice and making more referrals to sport psychologists. Conclusions: It was concluded that sport injury psychology education appears to be effective in increasing the sport psychology related behaviours (use of sport psychology and referral) of SIRPs and should be integrated into professional training

The effect of conspecific removal on the behaviour and physiology of pair-housed shelter dogs

Dogs (Canis familiaris) are a highly social species and within a shelter environment pair-housing is recommended to prevent the stress associated with social isolation. Separation of individuals which may have formed bonds in this environment is a usual occurrence, as a result of rehoming or euthanasia. To investigate the impact of separation, the behaviour, cognitive bias, faecal S-IgA and cortisol levels were examined in 12 adult pair-housed dogs, maintained in a private animal shelter. Prior to separation, dogs engaged in more affiliative than agonistic behaviour with conspecifics (means of 3 and 0.1% of time respectively). Following separation, increased activity was observed in the form of more running and grooming (P= 0.02), circling (P= 0.006), figure of 8 movement (P= 0.01), posture changes (P= 0.003) and stretching (P= 0.005), and less play behaviour was observed (P= 0.01). Secretory IgA increased (P=0.02) after separation (mean. = 443.7. ±. 182.5. ng/mL; before separation mean. = 370.1. ±. 108.2. ng/mL). Cortisol concentrations were not affected by separation (P= 0.26, mean before separation. = 792. ng/g; mean after separation. = 874. ng/g). There was no indication from cognitive bias testing that the dogs' emotional valency was affected, as latencies to reach ambiguous cues before and after separation did not differ significantly (P= 0.33). These results demonstrate that separation of a dog from a conspecific negatively affected behaviour and stimulated the immune system, changes which could be indicative of stress

What are the non-academic impacts of private tutoring? Voices from A-level students in UK urban schools

Private tutoring is a growing industry globally. Past research into the effectiveness of private tutoring has proved inconclusive. Studies dedicated to the non-academic implications of private tutoring are scarce. Using a mixed-method approach, our study examined A-Level students' experiences of private tutoring and their perceptions of benefits and drawbacks to additional tuition. The participants (N=26) were students from various UK urban schools who had used private tutoring during their A-Level studies. The study found that students generally felt private tutoring had a positive impact on their education and wellbeing, with many reporting increases in confidence and motivation. However, the additional workload and financial burden of tutoring had a negative impact, particularly as the frequency of private tutoring lessons was increased. Results also indicate that the availability and affordability of private tuition can create an unfair disadvantage for students from less affluent backgrounds. Based on these findings, the paper highlights the needs for governments to consider non-academic impacts of private tutoring, as well as issues related to the distribution of educational resources and provision of equal educational opportunities for all students. Implications for schools, parents, and students are included

Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension

BACKGROUND: Inflammation is a feature of pulmonary arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients with PAH. However, to date, no information exists on the significance of elevated cytokines or their potential as biomarkers. We sought to determine the levels of a range of cytokines in PAH and to examine their impact on survival and relationship to hemodynamic indexes. METHODS AND RESULTS: We measured levels of serum cytokines (tumor necrosis factor-alpha, interferon-gamma and interleukin-1beta, -2, -4, -5, -6, -8, -10, -12p70, and -13) using ELISAs in idiopathic and heritable PAH patients (n=60). Concurrent clinical data included hemodynamics, 6-minute walk distance, and survival time from sampling to death or transplantation. Healthy volunteers served as control subjects (n=21). PAH patients had significantly higher levels of interleukin-1beta, -2, -4, -6, -8, -10, and -12p70 and tumor necrosis factor-alpha compared with healthy control subjects. Kaplan-Meier analysis showed that levels of interleukin-6, 8, 10, and 12p70 predicted survival in patients. For example, 5-year survival with interleukin-6 levels of >9 pg/mL was 30% compared with 63% for patients with levels < or = 9 pg/mL (P=0.008). In this PAH cohort, cytokine levels were superior to traditional markers of prognosis such as 6-minute walk distance and hemodynamics. CONCLUSIONS: This study illustrates dysregulation of a broad range of inflammatory mediators in idiopathic and familial PAH and demonstrates that cytokine levels have a previously unrecognized impact on patient survival. They may prove to be useful biomarkers and provide insight into the contribution of inflammation in PAH

Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus

CONTEXT:The mechanism of action of metformin remains unclear. Given the regulation of the cortisol-regenerating enzyme 11βhydroxysteroid dehydrogenase 1 (11βHSD1) by insulin and the limited efficacy of selective 11βHSD1 inhibitors to lower blood glucose when co-prescribed with metformin, we hypothesized that metformin reduces 11βHSD1 activity.OBJECTIVE:To determine whether metformin regulates 11βHSD1 activity in vivo in obese men with and without type 2 diabetes mellitus.DESIGN:Double-blind, randomized, placebo-controlled, crossover study.SETTING:A hospital clinical research facility.PARTICIPANTS:Eight obese nondiabetic (OND) men and eight obese men with type 2 diabetes (ODM).INTERVENTION:Participants received 28 days of metformin (1 g twice daily), placebo, or (in the ODM group) gliclazide (80 mg twice daily) in random order. A deuterated cortisol infusion at the end of each phase measured cortisol regeneration by 11βHSD1. Oral cortisone was given to measure hepatic 11βHSD1 activity in the ODM group. The effect of metformin on 11βHSD1 was also assessed in human hepatocytes and Simpson-Golabi-Behmel syndrome adipocytes.MAIN OUTCOME MEASURES:The effect of metformin on whole-body and hepatic 11βHSD1 activity.RESULTS:Whole-body 11βHSD1 activity was approximately 25% higher in the ODM group than the OND group. Metformin increased whole-body cortisol regeneration by 11βHSD1 in both groups compared with placebo and gliclazide and tended to increase hepatic 11βHSD1 activity. In vitro, metformin did not increase 11βHSD1 activity in hepatocytes or adipocytes.CONCLUSIONS:Metformin increases whole-body cortisol generation by 11βHSD1 probably through an indirect mechanism, potentially offsetting other metabolic benefits of metformin. Co-prescription with metformin should provide a greater target for selective 11βHSD1 inhibitors

A Comparison of Physical Activity and Sedentary Lifestyle of University Employees through ActiGraph and IPAQ-LF

Introduction: The benefits of participating in physical activity (PA) are wide-ranging, such as lowering the risk of diabetes and anxiety. Employees’ engagement in PA can also benefit their employers due to the potential reduction in absenteeism and increased productivity. However, the PA levels and sedentary behaviour of university employees are yet to be examined using a mixed methods approach. This study aimed to monitor the PA and sedentary lifestyle (SL) of university employees’ objectively and subjectively for a whole week. Methods: Sixty-four employees (male = 33; female = 31) wore a PA monitor for a whole week and simultaneously completed the International Physical Activity Questionnaire Long Form (IPAQ-LF) to evaluate light, moderate to vigorous physical activity (MVPA), and SL amongst employees from different job roles such as Academics, Administration, and Professionals Service. Results: The ActiGraph results determined that employees engaged in significantly more light PA, and MVPA compared to the self-reported IPAQ-LF (p 0.05). However, there were significant differences across gender light PA Z = –6.139, p = .001, MVPA Z = –4.962, p = .001 but no significant differences in SL Z = –.869, p = .385. Also, there were significant differences across job roles light PA, MVPA (p 0.05). Discussion and conclusion: Findings suggest, IPAQ-LF presented lower light PA, MVPA, and SL than ActiGraph. Thus, considering the impact of prolonged SL on health and wellbeing, future research is needed to explore the challenges this population faces regarding PA engagement and propose potential interventions to reduce SL amongst university employees

The effectiveness, safety and cost-effectiveness of cytisine versus varenicline for smoking cessation in an Australian population: a study protocol for a randomized controlled non-inferiority trial

Smoking cessation medications are effective but often underutilised because of costs and side effects. Cytisine is a plant-based smoking cessation medication with over 50 years of use in Central and Eastern Europe. While cytisine has been found to be well-tolerated and more effective than nicotine replacement therapy, direct comparison with varenicline have not been conducted. This study evaluates the effectiveness, safety and cost-effectiveness of cytisine compared with varenicline.Two arm, parallel group, randomised, non-inferiority trial, with allocation concealment and blinded outcome assessment.Australian population-based study.Adult daily smokers (N=1266) interested in quitting will be recruited through advertisements and Quitline telephone-based cessation support services.Eligible participants will be randomised (1:1 ratio) to receive either cytisine capsules (25-day supply) or varenicline tablets (12-week supply), prescribed in accordance with the manufacturer's recommended dosing regimen. The medication will be mailed to each participant's nominated residential address. All participants will also be offered standard Quitline behavioural support (up to six 10-12 minute sessions).Assessments will be undertaken by telephone at baseline, 4- and 7-months post-randomisation. Participants will also be contacted twice (two and four weeks post-randomisation) to ascertain adverse events, treatment adherence and smoking status. The primary outcome will be self-reported 6-month continuous abstinence from smoking, verified by carbon monoxide at 7-month follow-up. We will also evaluate the relative safety and cost-effectiveness of cytisine compared with varenicline. Secondary outcomes will include self-reported continuous and 7-day point prevalence abstinence and cigarette consumption at each follow-up interview.If cytisine is as effective as varenicline, its lower cost and natural plant-based composition may make it an acceptable and affordable smoking cessation medication that could save millions of lives worldwide

The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis

Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. Raw data have been deposited in the Gene Expression Omnibus (GEO) (http://www.ncbi.nlm.nih.gov/geo/) under accession number GSE54810. Funding: This work was supported in part by grants to EMB from the MRC (G0501164) and BBSRC (BB/G009619/1), to EMB and NDR from the Wellcome Trust (WT093596MA), to MB from Imperial College London (Division of Investigative Sciences PhD Studentship), to HH from the ERA-NET PathoGenoMics project TRANSPAT, Austrian Science Foundation (FWF I282-B09), to SGF from the National Institutes of Health, USA (R01AI073829). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD