C60 fullerenes diminish muscle fatigue in rats comparable to N-acetylcysteine or β-Alanine

The aim of this study is to detect the effects of C60 fullerenes, which possess pronounced antioxidant properties, in comparison with the actions of the known exogenous antioxidants N-acetylcysteine (NAC) and β-Alanine in terms of exercise tolerance and contractile property changes of the m. triceps surae (TS) during development of the muscle fatigue in rats. The electrical stimulation of the TS muscle during four 30 min series in control rats led to total reduction of the muscle contraction force. Furthermore, the effects of prior intraperitoneal (i.p.) or oral C60FAS application and preliminary i.p. injection of NAC or β-Alanine on muscle contraction force under fatigue development conditions is studied. In contrast to control rats, animals with C60FAS, NAC, or β-Alanine administration could maintain a constant level of muscle effort over five stimulation series. The accumulation of secondary products and changes in antioxidant levels in the muscle tissues were also determined after the fatigue tests. The increased levels of lactic acid, thiobarbituric acid reactive substances and H2O2 after stimulation were statistically significant with respect to intact muscles. In the working muscle, there was a significant (p < 0.05) increase in the activity of endogenous antioxidants: reduced glutathione, catalase, glutathione peroxidase, and superoxide dismutase. Treated animal groups showed a decrease in endogenous antioxidant activity relative to the fatigue-induced animals (P < 0.05). Oral C60FAS administration clearly demonstrated an action on skeletal muscle fatigue development similar to the effects of i.p. injections of the exogenous antioxidants NAC or β-Alanine. This creates opportunities to oral use of C60FAS as a potential therapeutic agent. Due to the membranotropic activity of C60 fullerenes, non-toxic C60FAS has a more pronounced effect on the prooxidant-antioxidant homeostasis of muscle tissues in rats

A Genome-Wide Association Study of Sprint Performance in Elite Youth Football Players

Pickering, C, Suraci, B, Semenova, EA, Boulygina, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Leońska-Duniec, A, Pająk, B, Chycki, J, Moska, W, Lulińska-Kuklik, E, Dornowski, M, Maszczyk, A, Bradley, B, Kana-ah, A, Cięszczyk, P, Generozov, EV, and Ahmetov, II. A genome-wide association study of sprint performance in elite youth football players. J Strength Cond Res XX(X): 000-000, 2019-Sprint speed is an important component of football performance, with teams often placing a high value on sprint and acceleration ability. The aim of this study was to undertake the first genome-wide association study to identify genetic variants associated with sprint test performance in elite youth football players and to further validate the obtained results in additional studies. Using micro-array data (600 K-1.14 M single nucleotide polymorphisms [SNPs]) of 1,206 subjects, we identified 12 SNPs with suggestive significance after passing replication criteria. The polymorphism rs55743914 located in the PTPRK gene was found as the most significant for 5-m sprint test (p = 7.7 × 10). Seven of the discovered SNPs were also associated with sprint test performance in a cohort of 126 Polish women, and 4 were associated with power athlete status in a cohort of 399 elite Russian athletes. Six SNPs were associated with muscle fiber type in a cohort of 96 Russian subjects. We also examined genotype distributions and possible associations for 16 SNPs previously linked with sprint performance. Four SNPs (AGT rs699, HSD17B14 rs7247312, IGF2 rs680, and IL6 rs1800795) were associated with sprint test performance in this cohort. In addition, the G alleles of 2 SNPs in ADRB2 (rs1042713 & rs1042714) were significantly over-represented in these players compared with British and European controls. These results suggest that there is a genetic influence on sprint test performance in footballers, and identifies some of the genetic variants that help explain this influence

Champa Kingdom towers as a tourist attraction in Vietnam. Historical, geographical and architectural aspects

In the 17th century, the Champa Kingdom, which had operated for more than 1,000 years in what is now central and southern Vietnam, ceased to exist. The Hindu influence of the Cham state remained visible in the brick tower-temples that still exist, as well as in sculptures some of which are in Vietnamese museums. The first research into the Cham culture and history was carried out by French colonisers in the early 20th century, followed by Polish archaeologists and the Vietnamese government, among others. The study of the legacy left by the Cham poses significant difficulties, due to years of warfare, environmental influences, the passage of time and theft. However, the homogeneous culture and architectural structural integrity enable conducting a research analysis of the legacy left behind. The heterogeneous level of tourist development of the different tower groups poses a challenge to create a high standard of tourist attractiveness. The high quality of tourism provision characteristic of My Son and Po Nagar, setting an example to be followed throughout the Southeast Asian region, stands out against the low level of tourism development at other Cham temples

Organisational aspects of international relations in tourism on the example of Vietnam’s activity in The Association of Southeast Asian Nations (ASEAN)

In 1995, Vietnam became a member of the Association of Southeast Asian Nations – ASEAN, through which, among other things, international relations were regulated with China and the USA. Strengthening ASEAN, with more countries joining the Association and its partners, has influenced the economic development of the region. In this context, tourism has proved to be one of the key sectors of the economy of Vietnam and other ASEAN members, contributing to the competitiveness of Southeast Asia vis-à-vis China

THE IMPACT OF CLASSICAL MASSAGE ON SPINE MOBILITY

Introduction. Irregularities in movable property of the spine affect a large part of society and the problem affects the people at an increasingly younger age. Classical massage is a form of mechanotherapy that affects the regulation of the work of muscles, joints, tendons and ligaments. Aim of work: The purpose of this study was to evaluate the efficacy of classical massage section of thoracolumbar spine to increase the mobility in these segments. Material: The study was carried out on 36 healthy volunteers (20 women and 16 men) aged 21 to 27 years old (average age - 23.8) who were subjected to a series of five classical massages (according to strictly established protocol). In order to objectify the effects in all subjects before and after a series of treatments the following measurements were made: the fingers-floor test; the Otto -Wurna test; the straightening of the spine; lateral flexion of the spine; twist of the spine. Results A statistically important difference has been shown in the results of all tested variables before the first and after the last treatment of classical massage. Conclusions The results of personal research apply to young, healthy volunteers. It is worth to continue research into the effects of this form of therapy in the case of restrictions of movable tangible property, resulting from spinal pain syndromes

Здоровий спосіб життя і поведінка учнівської молоді

Introduction: A very important role in the protection of human health is their life style, their habits and patterns of conduct. Early adulthood is the best period to achieve long-term benefits from a selection of healthy living. However, the results of studies on health-related behavior of youth in Poland and in the world are not satisfactory. The purpose of the study: The purpose of the research was to assess the health behaviors of students of higher education in Bydgoszcz. Material: The study involved 272 students (124 women and 148 men) Bydgoszcz higher education students in the following fields of study: physiotherapy, nutrition, logistics and national security. The Inventory of Health-Related Behavior by Zygfryd Juczyński has been used in the research. The statistical analysis was performed using the package PQ Stat 1.6.2. Results: Throughout the treatment group an average level of health-related behavior has been shown. The results of the different categories of health-related behavior were lower than the results of the standardization groups. A higher level of health behavior has been shown in a group of medical students compared to non-medical students. The results for women were higher than men's results. Conclusions: The results of personal research and the research findings of other authors demonstrate that there is a need for implementation of programs of health promotion and health education in all fields of study.Введение: Очень важную роль в защите здоровья человека является их образ жизни, их привычки и модели поведения. Начало взрослой жизни является лучшим периодом для достижения долгосрочных выгод от выбора здорового образа жизни. Тем не менее, результаты исследований поведения, связанных со здоровьем молодежи в Польше и в мире не являются удовлетворительными. Цель исследования : Цель исследования заключалась в оценке поведения здоровья студентов высших учебных заведений в Быдгоще. Материал : В исследовании приняли участие 272 студентов (124 девушки и 148 юношей) студентов высших учебных заведений г. Быдгощ по следующим направлениям обучения: физиотерапия, питание, логистика и национальная безопасность. В исследованиях проведена оценка поведения, связанного со здоровьем, по системе Зигфрида Ясински. Статистический анализ проводился с использованием пакета PQ Stat 1.6.2. Результаты : установлен для всей исследуемой группы средний уровень поведения, связанного со здоровьем. Результаты различных категорий поведения, связанных со здоровьем, были ниже, чем результаты стандартной группы. Более высокий уровень поведения по отношению к здоровью был показан в группе студентов-медиков, по сравнению со студентами не медицинских специальностей. Результаты у девушек были выше, чем у юношей. Выводы : Результаты личных исследований и результаты исследований других авторов показывают, что существует необходимость в реализации программ укрепления здоровья и медицинского образования во всех областях.Вступ : Дуже важливу роль в захисті здоров'я людини є її спосіб життя, її звички і моделі поведінки. Початок дорослого життя є найкращим періодом для досягнення довгострокових вигод від вибору здорового способу життя. Проте, результати досліджень поведінки, пов'язаної зі здоров'ям молоді в Польщі і в світі, не є задовільними. Мета дослідження : Мета дослідження полягала в оцінці поведінки здоров'я студентів вищих навчальних закладів в м.Бидгощ. Матеріал : У дослідженні взяли участь 272 студента (124 дівчини і 148 юнаків) студентів вищих навчальних закладів м Бидгощ за наступними напрямками навчання: фізіотерапія, харчування, логістика та національна безпека. У дослідженнях проведена оцінка поведінки, пов'язаної зі здоров'ям, за системою Зігфріда Ясинського. Статистичний аналіз проводився з використанням пакету PQ Stat 1.6.2. Результати : встановлено для всієї досліджуваної групи середній рівень поведінки, пов'язаної зі здоров'ям. Результати різних категорій поведінки, пов'язаної зі здоров'ям, були нижче, ніж результати стандартної групи. Більш високий рівень поведінки по відношенню до здоров'я був показаний в групі студентів-медиків, в порівнянні зі студентами не медичних спеціальностей. Результати у дівчат були вище, ніж у юнаків. Висновки : Результати особистих досліджень та результати досліджень інших авторів показують, що існує необхідність у реалізації програм зміцнення здоров'я і медичної освіти в усіх областях