The potential of Antheraea pernyi silk for spinal cord repair

This work was supported by the Institute of Medical Sciences of the University of Aberdeen, Scottish Rugby Union and RS McDonald Charitable Trust. We are grateful to Mr Nicholas Hawkins from Oxford University and Ms Annette Raffan from the University of Aberdeen for assistance with tensile testing. We thank Ms Michelle Gniβ for her help with the microglial response experiments. We also thank Mr Gianluca Limodio for assisting with the MATLAB script for automation of tensile testing’s data analysis.Peer reviewedPublisher PD

Investigation of Thermal Creep and Thermal Stress Effects in Microgravity Physical Vapor Transport

Reported here are the results of our numerical investigation into the mechanisms which affect the transport and growth processes in physical vapor transport (PVT) crystal growth ampoules. The first part of the report consists of a brief summary of the major accomplishments and conclusions of our work. The second part consists of two manuscripts, submitted to the Journal of Crystal Growth, which provided a detailed description of the findings in our investigation

Reducing parental anxiety using a family based intervention for youth mental health : a randomized controlled trial

This paper presents findings on parent anxiety and attachment relationship style from the Deakin Family Options (DFO) pilot study, a randomized controlled pilot study comparing a family-based treatment (BEST Plus), versus a youth only treatment (CBT) versus a group who received both of these treatments (COMBINED). Eligible participants were families with a young person (aged 12 - 25 years) with a high prevalence mental health problem. Youth from participating families scored in the clinical or subclinical range for depression, anxiety and/or substance misuse symptoms on standardized measures during the initial assessment. The collected sample was drawn from regional and urban centers in Victoria, Australia and allocated to treatment condition using a simple randomization procedure (parallel design). It was hypothesized that families receiving the BEST Plus would experience greater reductions in youth and parent mental health symptoms, and improved parent-child relationships, compared with those in the CBT condition. This paper describes and discusses changes in parent anxiety and parent attachment, according to whether the parent participated in a treatment (BEST Plus) or did not (NONBEST Plus). Participants were blind to the study hypotheses. In total 71 parent participants returned pre data and were allocated to a treatment group. In this paper, data from parent participants who completed pre and post measures (n = 48) and pre, post, and 6-month follow-up measures (n = 28) on anxiety and attachment were analyzed by group (BEST Plus versus NONBEST Plus). The results of this study suggest that parent anxiety decreased significantly more following parent involvement in a group treatment, than for parents that did not receive treatment. Unexpectedly, avoidant attachment increased in the no treatment group, but remained relatively stable following the BEST Plus group. There were no significant findings in relation to compulsive traits and anxious attachment. These findings are discussed in light of the study limitations.<br /

Depth-averaged simulation of flows in asymmetric compound channels with smooth and rough narrow floodplains

Depth-averaged hydrodynamic models are predominantly used in numerical simulations of compound channel flows. One of the most popular methods for the depth-averaged simulation is Shiono and Knight method (SKM). This method accounts for the effects of bed friction, lateral turbulence and secondary flows, via three key parameters f, λ and Γ, respectively. The conventional expressions that are developed to calibrate these parameters are generally based on experiments in compound channels with wide floodplains. In this study, the application of SKM to an asymmetric compound channel with a narrow floodplain is examined in terms of the calibration requirements. Two sets of experiments that have smooth and rough floodplains are conducted and then simulated by SKM. In smooth floodplain cases, the results reveal that SKM model with the conventional calibration expressions of f, λ and Г is reasonably capable of predicting the distributions of depth-averaged velocity and boundary shear stress in the main channel. However, in the floodplain region, the expressions recommended for calibrating Г need to be modified to improve the predicted results in that region. In cases of the rough floodplain, the results indicate that only the values of λ in the main channel need to be changed from its conventional values to improve the predictions

Coupled-mode theory for photonic band-gap inhibition of spatial instabilities

We study the inhibition of pattern formation in nonlinear optical systems using intracavity photonic crystals. We consider mean-field models for singly and doubly degenerate optical parametric oscillators. Analytical expressions for the new (higher) modulational thresholds and the size of the "band gap" as a function of the system and photonic crystal parameters are obtained via a coupled-mode theory. Then, by means of a nonlinear analysis, we derive amplitude equations for the unstable modes and find the stationary solutions above threshold. The form of the unstable mode is different in the lower and upper parts of the band gap. In each part there is bistability between two spatially shifted patterns. In large systems stable wall defects between the two solutions are formed and we provide analytical expressions for their shape. The analytical results are favorably compared with results obtained from the full system equations. Inhibition of pattern formation can be used to spatially control signal generation in the transverse plane

Mountain Pine Beetle Outbreaks in the Rocky Mountains: Regulators of Primary Productivity?

We consider the hypothesis that mountain pine beetles function as cybernetic regulators of primary productivity in ecosystems of lodgepole pine forest through their selective killing of dominant trees and the subsequent redistribution of resources. Following a recent major beetle outbreak in Yellowstone and Grand Teton national parks, surviving trees did grow significantly faster (P \u3c .1); wood production was redistributed among canopy, subcanopy, and understory trees; and annual wood production per hectare usually returned to pre-attack levels or exceeded them within 10-15 yr. However, reconstructions of annual wood production over the last 70-80 yr indicate that the beetle outbreak did not reduce the variation in productivity; rather, the beetles introduced more variation than would have existed in their absence. Hence, our results do not support the hypothesis that the beetles function as cybernetic regulators (in the strict sense). Nevertheless, the beetle-pine system that we studied shows great resilience, and the effects of beetles on primary productivity do not appear to be as severe as conventional wisdom maintains. Annual wood production per hectare returned quickly to previous levels in the stands we studied, and associated ecological changes can be considered generally benign or even beneficial

Water and Nutrient Outflow From Contrasting Lodgepole Pine Forests in Wyoming

Factors affecting water and nutrient outflow beyond the rooting zone were studied during a 3—yr period, using data from eight contrasting stands of lodgepole pine (Pinus contorta ssp. latifolia) forest in southeastern Wyoming and the output of a hydrologic simulation model (H2OTRANS) based on tree physiology. Nutrient outflow during a specific time period was estimated by multiplying simulated water outflow times element concentrations in the soil solution, the latter determined from samples collected periodically near the bottom of the rooting zone. Estimates of actual evapotranspiration (ET) for the period from early spring to late fall ranged from 21 to 53 cm, which was 33—95% (x = 73%) of total annual precipitation. For all stands and years, transpiration accounted for 50—61% of ET, and 9—44% of the transpiration occurred during the spring drainage period (vernal transpiration, VT). Estimated VT and outflow varied considerably among the stands, with VT accounting for 4—20% of the snow water. Outflow occurred only during the snow melt period and accounted for 0—80% of the snow water. Snow water equivalent varied annually by 300% or more. Nutrient outflow from the different stands also varied greatly. Ratios between simulated annual outflow and atmospheric inputs (bulk precipitation) were consistently \u3e1.0 for Ca, Na, and Mg; were consistently \u3c1.0 for N; and ranged from 0.3 to 2.0 for P and from 0.2 to 3.3 for K. Much of the variability in water and nutrient outflow can be attributed to the degree of biotic control, with water outflow affected by a different combination of factors than nutrient outflow. H2OTRANS was used to simulate the effects on outflow of different snow water equivalents and different total leaf areas. One result of the simulations was that nitrogen appears to be retained even at the highest levels of water outflow. Another was that increases in water outflow following reduction in leaf area were proportional to the leaf area removed. The results indicate that stands differing in site or habitat type experience different rates of water and element losses at different times during the snow melt season, and contribute differentially to streamwater quality and hydrograph shape. Factors affecting outflow are discussed in the context of successional trends, common perturbations including timber harvest, and hypotheses pertaining to nutrient conservation in terrestrial ecosystems. Nutrient retention in the snow—dominated lodgepole pine ecosystem appears to be primarily dependent on evergreen leaf area, duration of the VT period, and high carbon/nutrient ratios of the forest floor. Net losses of limiting nutrients probably occur primarily in pulses after abiotic perturbations such as fire