Analysis of Burning Wood in the Transient State and the Application to Structural Design

Determining the extent of the contribution of exposed timber on compartment fire dynamics in open floor plans is a complex process. Designers traditionally used compartmentalization design methods which create spaces where flashover is likely, given the fuel load and ventilation conditions. However, due to the large geometric dimensions and spread of fuel, fires in open floor plans are more likely to remain as localized or traveling fires. As such, an understanding of not only ignition potential but also flame spread is critical to characterizing the contribution of exposed timber. An integral step in characterizing the potential contribution is through an analysis of the transient phase of burning of timber and the phenomena of self-extinction in this phase of burning. A series of material characterization experiments were conducted on Douglas Fir Larch samples to observe the behavior of timber in transient burning under a wide range of heat fluxes. For each experiment, the temperature gradient was recorded with thermocouples while the mass loss rate was measured using a load cell. The rate of conduction into the virgin timber, critical heat flux and the mass loss rate needed for sustained burning were all calculated to provide bounding limits to flame spread and self-extinction. These experiments showed that the transient mass loss rate is significantly higher than the average steady state in exposed wood and that there are nuances from latent heat of vaporization that notably affect the charring rates. This project begins to develop the effects that the transient state can have in burning wood and its charring rates. As a result, it was found that the mass loss rate during the transient state is significant and thus should be considered for the design of exposed timber. These studies should be further developed and tested to help refine charring rates during the transient state and with larger scale tests begin to be applied towards the structural engineering of exposed wood under a fire event

Design, Synthesis and Characterization of N-oxide-containing Heterocycles with In vivo Sterilizing Antitubercular Activity

Tuberculosis, caused by the Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide- containing compounds were synthesized followed by in vitro and in vivo evaluation of their antitubercular potential against Mtb. Compound 8 was found to be the most promising compound, with MIC90 values of 1.10 and 6.62 μM against active and non- replicating Mtb, respectively. Additionally, we carried out in vivo experiments to confirm the safety and efficacy of compound 8; the compound was found to be orally bioavailable and highly effective leading to the reduction of the number of Mtb to undetected levels in a mouse model of infection. Microarray-based initial studies on the mechanism of action suggest that compound 8 blocks the process of translation. Altogether, these results indicated benzofuroxan derivative 8 to be a promising lead compound for the development of a novel chemical class of antitubercular drugs

La propaganda como imagen de perpetrador: Escorzos de la Guerra de Malvinas en 1982, de Lucas Gallo

Este artículo explora los modos en que las imágenes de perpetradores pueden encarnarse en las maquinarias propagandísticas. En este sentido, analiza parte del archivo de la televisión oficial durante la Guerra de las Islas Malvinas a partir del film documental 1982 (Lucas Gallo, 2020), con el fin de elaborar una revisión no sólo de la imbricación de las imágenes con las políticas de exterminio, sino para discutir la concepción del archivo como ficción y como instrumento de la memoria.This article explores the ways in which images of perpetrators can be embodied in propaganda machines. In this sense, it analyzes part of the archive material of the Argentine official television during the Malvinas War that appears in the documentary film 1982 (Lucas Gallo, 2020), in order to elaborate a review not only of the imbrication of the images with the policies of extermination, but to discuss the conception of the archive as fiction and as an instrument of memory.Fil: Taccetta, Natalia Roberta. Universidad de Buenos Aires. Facultad de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Veliz, Mariano Sebastian. Universidad de Buenos Aires. Facultad de Filosofía y Letras; Argentin

Design, Synthesis, and Characterization of N‑Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity

Tuberculosis, caused by Mycobacterium tuberculosis (<i>Mtb</i>), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide-containing compounds were synthesized followed by <i>in vitro</i> and <i>in vivo</i> evaluation of their antitubercular potential against <i>Mtb</i>. Compound <b>8</b> was found to be the most promising compound, with MIC₉₀ values of 1.10 and 6.62 μM against active and nonreplicating <i>Mtb</i>, respectively. Additionally, we carried out <i>in vivo</i> experiments to confirm the safety and efficacy of compound <b>8</b>; the compound was found to be orally bioavailable and highly effective, leading to a reduction of <i>Mtb</i> to undetectable levels in a mouse model of infection. Microarray-based initial studies on the mechanism of action suggest that compound <b>8</b> blocks translation. Altogether, these results indicate that benzofuroxan derivative <b>8</b> is a promising lead compound for the development of a novel chemical class of antitubercular drugs