Redesign of english i and ii syllabuses based on ict’s of the majors of Licenciatura en Administración de Empresas and Licenciatura en Contaduría Pública at the Western Multidisciplinary Campus of the University of El Salvador, 2019

The research project presents an analysis of the current English I and II Syllabuses of Licenciatura en Administración de Empresas y Licenciatura en Contaduría Pública of the University of El Salvador, Western Multidisciplinary Campus and a proposal of changes of the Redesign of the English Syllabus I and II of the two majors

Plan de negocio para la empresa HUK

Es un hecho que el uso de las bicicletas ya sea como medio de transporte o como deporte se ha visto incrementado a raíz de la pandemia. En el año 2020, se vendieron alrededor de 30,000 unidades y se prevé que para el próximo año la demanda aumente. Solamente en el primer trimestre de 2021, la importación de bicicletas tradicionales y eléctricas creció más del 1,000% respecto al mismo periodo del año anterior (How2Go, 2021). En este contexto, el ciclismo de montaña y ruta es un deporte que cada vez gana más adeptos en Perú y es que nuestra diversidad geográfica (costa, sierra y selva) y nuestros bellos paisajes facilitan y propician el desarrollo de este deporte, sumado a la necesidad creciente de realizar actividades al aire libre evitando así el riesgo de contagio. El presente plan de negocio para la empresa HUK busca brindarle a un segmento de la población limeña, la posibilidad de practicar el ciclismo de montaña y/o ruta con bicicletas de fibra de carbono de la más alta calidad, fabricadas totalmente a su medida y gusto. Para ello brindaremos un asesoramiento personalizado a través de nuestra tienda física y nuestros canales digitales con el objetivo de que cada uno de nuestros clientes obtenga un producto único diseñado acorde a sus necesidades. Si bien actualmente (2021) existen diversas marcas que ofrecen bicicletas de alta gama en el mercado, ninguna cuenta con la tecnología brindada por nuestra casa matriz que nos permite utilizar impresoras 3D para fabricar los marcos de bicicleta de fibra de carbono a medida del cliente. Este atributo sumado a nuestro servicio de asesoría personalizado nos permite diferenciarnos de la competencia y ganar un posicionamiento en el mercado. Nuestro plan de negocio consta de nueve capítulos en los que plantearemos nuestra idea de negocio, analizaremos el entorno externo e interno en el cual se llevará a cabo el negocio, identificaremos nuestros objetivos y nuestra estrategia para luego pasar a los planes de ejecución. En ellos detallaremos cómo vamos a llegar a nuestros clientes y capturarlos, cuáles serán nuestros procesos claves y cómo los llevaremos a cabo, cuántas personas necesitamos y bajo qué capacidades y finalmente traduciremos todos estos planes en presupuestos para determinar la rentabilidad y viabilidad del negocio. HUK espera ser un negocio sostenible al obtener una buena rentabilidad para los accionistas, al preocuparnos por tener un impacto positivo en el medio ambiente y finalmente, al brindarle a la sociedad la posibilidad de hacer un deporte que contribuya a tener un estilo de vida saludable

Extension of coverage to vulnerable groups of a population

En esta monografía se presenta la información necesaria para mejorar la cobertura de apoyo social a los grupos vulnerables del país, a través de la identificación de los actuales programas que maneja el Gobierno y las Organizaciones no Gubernamentales para mejorar la situación de pobreza que aumenta considerablemente en el país señalando los grupos vulnerables mas representativos.Universidad CES1. INTRODUCCION 2. OBJETIVOS 2.1 OBJETIVO GENERAL 2.2 OBJETIVOS ESPECÍFICOS 3. METODOLOGÍA 4. ANÁLISIS DE RESULTADOS 4.1 SITUACIÓN ACTUAL DE LA EXTENCIÓN DE COBERTURA A GRUPOS VULNERABLES 4.1.1 Asistencia a Grupos Vulnerables en América Central 4.1.2 Asistencia a Grupos Vulnerables en Colombia 4.2 SITUACIÓN ACTUAL DE UN GRUPO POBLACIONAL 4.3 PROYECTOS DE CONVERSIÓN SOCIAL ENTRE EL GOBIERNO Y LAS ORGANIZACIONES NO GUBERNAMENTALES PARA LA ATENCIÓN A GRUPOS VULNERABLES 4.4 IMPORTANCIA DE VINCULACIÓN DE GRUPOS VULNERABLES A REDES SOCIALES DE PROTECCIÓN 5. CONCLUSIONES 6. BIBLIOGRAFÍA 7. ANEXOSEspecializaciónThis monograph presents the information necessary to improve the coverage of social support for vulnerable groups in the country, through the identification of current programs managed by the Government and Non-Governmental Organizations to improve the situation of poverty that increases considerably in the country indicating the most representative vulnerable groups

Addressing acute stress among professionals caring for COVID-19 patients: lessons learned during the first outbreak in Spain (March–April 2020)

To describe lessons learned during the first COVID-19 outbreak in developing urgent interventions to strengthen healthcare workers’ capacity to cope with acute stress caused by health care pressure, concern about becoming infected, despair of witnessing patients’ suffering, and critical decision-making requirements of the SARS-CoV-2 pandemic during the first outbreak in Spain. Methods: A task force integrated by healthcare professionals and academics was activated following the first observations of acute stress reactions starting to compromise the professionals’ capacity for caring COVID-19 patients. Literature review and qualitative approach (consensus techniques) were applied. The target population included health professionals in primary care, hospitals, emergencies, and nursing homes. Interventions designed for addressing acute stress were agreed and disseminated. Findings: There are similarities in stressors to previous outbreaks, and the solutions devised then may work now. A set of issues, interventions to cope with, and their levels of evidence were defined. Issues and interventions were classified as: adequate communication initiative to strengthen work morale (avoiding information blackouts, uniformity of criteria, access to updated information, mentoring new professionals); resilience and recovery from physical and mental fatigue (briefings, protecting the family, regulated recovery time during the day, psychological first aid, humanizing care); reinforce leadership of intermediate commands (informative leadership, transparency, realism, and positive messages, the current state of emergency has not allowed for an empirical analysis of the effectiveness of proposed interventions. Sharing information to gauge expectations, listening to what professionals need, feeling protected from threats, organizational flexibility, encouraging teamwork, and leadership that promotes psychological safety have led to more positive responses. Attention to the needs of individuals must be combined with caring for the teams responsible for patient care. Conclusions: Although the COVID-19 pandemic has a more devastating effect than other recent outbreaks, there are common stressors and lessons learned in all of them that we must draw on to increase our capacity to respond to future healthcare crises

Cuidado de enfermería en situaciones de enfermedad crónica

Cuidado de enfermería en situaciones de enfermedad crónica es un texto dirigido al equipo de enfermería que se encuentra en ejercicio profesional y para aquellos que están en formación, interesados en conocer y profundizar en el abordaje de personas que cursan con enfermedades crónicas desde la perspectiva del reconocimiento de necesidades de cuidado. Este trabajo es producto de la revisión de literatura actualizada y vigente de cada una de las temáticas expuestas en torno a la cronicidad; refleja la experiencia desde la docencia, la investigación y el ejercicio profesional de los autores, proporcionando un marco de referencia que contribuya a la aplicación de propuestas de intervención en la práctica, dirigidas a las personas con enfermedades crónicas y a sus cuidadores familiares. Se parte de la reflexión y el estudio de la problemática de las enfermedades crónicas, como tendencia en el ámbito mundial que requiere la vinculación de diferentes actores partícipes con propuestas novedosas en las fases de prevención y detección precoz, diagnóstico, tratamiento, rehabilitación y reinclusión social.Introducción Primera parte Fundamentación teórica de enfermería en la cronicidad Abordajes teóricos de enfermería en situaciones de cronicidad Lorena Chaparro Díaz Enfrentando la depresión en situaciones de cronicidad Lucy Barrera Ortiz Los estilos de vida saludable para prevenir la enfermedad crónica Natividad Pinto Afanador Enfermedad crónica y cuidado espiritual Beatriz Sánchez Herrera Por favor, cuídame: estoy viviendo un duelo! Beatriz Sánchez Herrera El dolor una necesidad de cuidado en la cronicidad Gloria Mabel Carrillo González Segunda parte Experiencias en el cuidado de personas con enfermedad crónica Cuidado de enfermería a la persona con diabetes: el caso de Julia Lina María Vargas Escobar Ángela Lucila Barrios Díaz Jorge Esteban García Forero Cuidado de enfermería a la persona con heridas crónicas y ostomías: el caso de Lucy 185Alejandra Fuentes Ramírez Cuidado de enfermería a la persona con enfermedades respiratorias crónicas: el caso de Rafael Jenny Paola Blanco Sonia Patricia Carreño Cuidado de enfermería a la persona con cáncer: el caso de Mariana Carmen Helena Avell

Lo glocal y el turismo. Nuevos paradigmas de interpretación.

El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global

Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours : results from the COPPADIS cohort

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks : The GR@ACE project

Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series

Mutational Landscape of CEBPA in Mexican Pediatric Acute Myeloid Leukemia Patients: Prognostic Implications

BackgroundIn Mexico, the incidence of acute myeloid leukemia (AML) has increased in the last few years. Mortality is higher than in developed countries, even though the same chemotherapy protocols are used. CCAAT Enhancer Binding Protein Alpha (CEBPA) mutations are recurrent in AML, influence prognosis, and help to define treatment strategies. CEBPA mutational profiles and their clinical implications have not been evaluated in Mexican pediatric AML patients.Aim of the StudyTo identify the mutational landscape of the CEBPA gene in pediatric patients with de novo AML and assess its influence on clinical features and overall survival (OS).Materials and MethodsDNA was extracted from bone marrow aspirates at diagnosis. Targeted massive parallel sequencing of CEBPA was performed in 80 patients.ResultsCEBPA was mutated in 12.5% (10/80) of patients. Frameshifts at the N-terminal region were the most common mutations 57.14% (8/14). CEBPA biallelic (CEBPABI) mutations were identified in five patients. M2 subtype was the most common in CEBPA positive patients (CEBPAPOS) (p = 0.009); 50% of the CEBPAPOS patients had a WBC count &gt; 100,000 at diagnosis (p = 0.004). OS &gt; 1 year was significantly better in CEBPA negative (CEBPANEG) patients (p = 0.0001). CEBPAPOS patients (either bi- or monoallelic) had a significantly lower OS (p = 0.002). Concurrent mutations in FLT3, CSF3R, and WT1 genes were found in CEBPAPOS individuals. Their contribution to poor OS cannot be ruled out.ConclusionCEBPA mutational profiles in Mexican pediatric AML patients and their clinical implications were evaluated for the first time. The frequency of CEBPAPOS was in the range reported for pediatric AML (4.5–15%). CEBPA mutations showed a negative impact on OS as opposed to the results of other studies

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality