EasyText : : un système opérationnel de génération de textes

International audienceThis paper introduces EasyText, a fully oper- ational NLG System. This application pro- cesses numerical data (in tables) in order to generate specific analytical comments of these tables.Cet article présente rapidement EasyText, un système opérationnel de génération de textes

The French Social Media Bank: a Treebank of Noisy User Generated Content

International audienceIn recent years, statistical parsers have reached high performance levels on well-edited texts. Domain adaptation techniques have improved parsing results on text genres differing from the journalistic data most parsers are trained on. However, such corpora usually comply with standard linguistic, spelling and typographic conventions. In the meantime, the emergence of Web 2.0 communication media has caused the apparition of new types of online textual data. Although valuable, e.g., in terms of data mining and sentiment analysis, such user-generated content rarely complies with standard conventions: they are noisy. This prevents most NLP tools, especially treebank based parsers, from performing well on such data. For this reason, we have developed the French Social Media Bank, the first user-generated content treebank for French, a morphologically rich language (MRL). The first release of this resource contains 1,700 sentences from various Web 2.0 sources, including data specifically chosen for their high noisiness. We describe here how we created this treebank and expose the methodology we used for fully annotating it. We also provide baseline POS tagging and statistical constituency parsing results, which are lower by far than usual results on edited texts. This highlights the high difficulty of automatically processing such noisy data in a MRL

EasyText: an Operational NLG System

This paper introduces EasyText, a fully operational NLG system. This application processes numerical data (in tables) in order to generate specific analytical commentaries of these tables. We start by describing the context of this particular NLG application (communicative goal, user profiles, etc.). We then shortly present the theoretical background which underlies EasyText, before describing its implementation, realization and evaluation.

Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Is a Fully Penetrant, Lethal Arrhythmic Disorder Caused by a Missense Mutation in the TMEM43 Gene

Autosomal-dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) causes sudden cardiac death and is characterized by clinical and genetic heterogeneity. Fifteen unrelated ARVC families with a disease-associated haplotype on chromosome 3p (ARVD5) were ascertained from a genetically isolated population. Identification of key recombination events reduced the disease region to a 2.36 Mb interval containing 20 annotated genes. Bidirectional resequencing showed one rare variant in transmembrane protein 43 (TMEM43 1073C→T, S358L), was carried on all recombinant ARVD5 ancestral haplotypes from affected subjects and not found in population controls. The mutation occurs in a highly conserved transmembrane domain of TMEM43 and is predicted to be deleterious. Clinical outcomes in 257 affected and 151 unaffected subjects were compared, and penetrance was determined. We concluded that ARVC at locus ARVD5 is a lethal, fully penetrant, sex-influenced morbid disorder. Median life expectancy was 41 years in affected males compared to 71 years in affected females (relative risk 6.8, 95% CI 1.3–10.9). Heart failure was a late manifestation in survivors. Although little is known about the function of the TMEM43 gene, it contains a response element for PPARγ (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC

Profound, prelingual nonsyndromic deafness maps to chromosome 10q21 and is caused by a novel missense mutation in the Usher syndrome type IF gene PCDH15

We studied a consanguineous family (Family A) from the island of Newfoundland with an autosomal recessive form of prelingual, profound, nonsyndromic sensorineural hearing loss. A genome-wide scan mapped the deafness trait to 10q21-22 (max LOD score of 4.0; D10S196) and fine mapping revealed a 16 Mb ancestral haplotype in deaf relatives. The PCDH15 gene was mapped within the critical region and was an interesting candidate because truncating mutations cause Usher syndrome type IF (USH1F) and two missense mutations have been previously associated with isolated deafness (DFNB23). Sequencing of the PCDH15 gene revealed 33 sequencing variants. Three of these variants were homozygous exclusively in deaf siblings but only one of them was not seen in ethnically matched controls. This novel c.1583 T>A transversion predicts an amino-acid substitution of a valine with an aspartic acid at codon 528 (V528D). Like the two DFNB23 mutations, the V528D mutation in Family A occurs in a highly conserved extracellular cadherin (EC) domain of PCDH15 and is predicted to be more deleterious than the previously identified DFNB23 missense mutations (R134G and G262D). Physical assessment, vestibular and visual function testing in deaf adults ruled out syndromic deafness because of Usher syndrome. This study validates the DFNB23 designation and supports the hypothesis that missense mutations in conserved motifs of PCDH15 cause nonsyndromic hearing loss. This emerging genotype–phenotype correlation in USH1F is similar to that in several other USH1 genes and cautions against a prognosis of a dual sensory loss in deaf children found to be homozygous for hypomorphic mutations at the USH1F locus