Many stimuli pull the necrotic trigger, an overview

The lab of Jürg Tschopp was the first to report on the crucial role of receptor-interacting protein kinase 1 (RIPK1) in caspase-independent cell death. Because of this pioneer finding, regulated necrosis and in particular RIPK1/RIPK3 kinase-mediated necrosis, referred to as necroptosis, has become an intensively studied form of regulated cell death. Although necrosis was identified initially as a backup cell death program when apoptosis is blocked, it is now recognized as a cellular defense mechanism against viral infections and as being critically involved in ischemia-reperfusion damage. The observation that RIPK3 ablation rescues embryonic lethality in mice deficient in caspase-8 or Fas-associated-protein-via-a-death-domain demonstrates the crucial role of this apoptotic platform in the negative control of necroptosis during development. Here, we review and discuss commonalities and differences of the increasing list of inducers of regulated necrosis ranging from cytokines, pathogen-associated molecular patterns, to several forms of physicochemical cellular stress. Since the discovery of the crucial role of RIPK1 and RIPK3 in necroptosis, these kinases have become potential therapeutic targets. The availability of new pharmacological inhibitors and transgenic models will allow us to further document the important role of this form of cell death in degenerative, inflammatory and infectious diseases

Proceedings Ocean Biodiversity Informatics: International Conference on Marine Biodiversity Data Management, Hamburg, Germany 29 November to 1 December, 2004

The International conference on Marine Biodiversity Data management ‘Ocean Biodiversity Informatics’ was held in Hamburg, Germany, from 29 November to 1 December 2004. Its objective was to offer a forum to marine biological data managers to discuss the state of the field, and to exchange ideas on how to further develop marine biological data systems. Many marine biologists are actively gathering knowledge, as they have been doing for a long time. What is new is that many of these scientists are willing to share their knowledge, including basic data, with others over the Internet. Our challenge now is to try and manage this trend, avoid confusing users with a multitude of contradicting sources of information, and make sure different data systems can be and are effectively integrated

The Colour of Ocean Data: International Symposium on oceanographic data and information management, with special attention to biological data. Brussels, Belgium, 25-27 November 2002: book of abstracts

Ocean data management plays a crucial role in global as well as local matters. The Intergovernmental Oceanographic Commission -with its network of National Oceanographic Data Centres- and the International Council of Scientific Unions- with its World Data Centres- have played a major catalysing role in establishing the existing ocean data management practices. No one can think of data management without thinking of information technology. New developments in computer hard- and software force us to continually rethink the way we manage ocean data. One of the major challenges in this is to try and close the gap between the haves and the have-nots, and to assist scientists in less fortunate countries to manage oceanographic data flows in a suitable and timely fashion. So far major emphasis has been on the standardisation and exchange of physical oceanographic data in open ocean conditions. But the colour of the ocean data is changing. The ‘blue’ ocean sciences get increasingly interested in including geological, chemical and biological data. Moreover the shallow sea areas get more and more attention as highly productive biological areas that need to be seen in close association with the deep seas. How to fill in the gap of widely accepted standards for data structures that can serve the deep ‘blue’ and the shallow ‘green’ biological data management is a major issue that has to be addressed. And there is more: data has to be turned into information. In the context of ocean data management, scientists, data managers and decision makers are all very much dependent on each other. Decision makers will stimulate research topics with policy priority and hence guide researchers. Scientists need to provide data managers with reliable and first quality controlled data in such a way that the latter can translate and make them available for the decision makers. But do they speak the same ‘language’? Are they happy with the access they have to the data? And if not, can they learn from each other’s expectations and experience? The objective of this symposium is to harmonize ocean colours and languages and create a forum for data managers, scientists and decision makers with a major interest in oceanography, and open to everyone interested in ocean data management

Ceramic production in the Kur River Basin (Fars, Iran) during the middle to late second millennium bce: a geochemical and technological characterization.

A total of 119 middle to late second millennium bce pottery samples from six sites in the Kur River Basin (Fars, Iran) were examined to characterize these ceramics and reconstruct their manufacturing technology and the origin of the primary materials. For this, a combined study of handheld XRF and thin‐section petrography was performed. The geochemical signatures of these ceramics were defined and interpreted in their archaeological and geological framework, resulting in the determination of different production processes and clay types used for four ceramic wares (Middle Elamite, Qaleh, Shogha and Taimuran) and the identification of possible outcrops used for Shogha–Taimuran production