95 research outputs found
A systematic model identification method for chemical transformation pathways – the case of heroin biomarkers in wastewater
Abstract This study presents a novel statistical approach for identifying sequenced chemical transformation pathways in combination with reaction kinetics models. The proposed method relies on sound uncertainty propagation by considering parameter ranges and associated probability distribution obtained at any given transformation pathway levels as priors for parameter estimation at any subsequent transformation levels. The method was applied to calibrate a model predicting the transformation in untreated wastewater of six biomarkers, excreted following human metabolism of heroin and codeine. The method developed was compared to parameter estimation methods commonly encountered in literature (i.e., estimation of all parameters at the same time and parameter estimation with fix values for upstream parameters) by assessing the model prediction accuracy, parameter identifiability and uncertainty analysis. Results obtained suggest that the method developed has the potential to outperform conventional approaches in terms of prediction accuracy, transformation pathway identification and parameter identifiability. This method can be used in conjunction with optimal experimental designs to effectively identify model structures and parameters. This method can also offer a platform to promote a closer interaction between analytical chemists and modellers to identify models for biochemical transformation pathways, being a prominent example for the emerging field of wastewater-based epidemiology
Model-based identification of chemicals transformation pathways combined with reaction kinetics models– the case of heroin biomarkers in wastewater
Bioflocculation of green microalgae using activated sludge and potential for biogas production
Monitoring of primary treatment: Estimation of the bioavailable organic carbon in wastewater by measuring the total organic solids (TSS) and turbidity
Towards an optimal experimental design for N2O model calibration during biological nitrogen removal
Nitrogen recovery from wastewater to produce microbial protein using methane oxidizing bacteria
Impact of influent quality on green microalgal cultivation with used water resources – experimental assessment combined with image analysis
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