11 research outputs found
Can Dexmedetomidine Prevent the Unwanted Hemolytic Events in the Glucose-6-Phosphate Dehydrogenase-deficient Person Undergoing Cardiac Surgery?
Exaggeration of hypoxic lung injury in a patient with glucose- 6-phosphate dehydrogenase deficiency
LOW RISK OF BACTEREMIA IN OTHERWISE HEALTHY CHILDREN PRESENTING WITH FEVER AND SEVERE NEUTROPENIA
Anaesthetic management in patients with glucose-6-phosphate dehydrogenase deficiency undergoing neurosurgical procedures
Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is an X-linked recessive enzymopathy responsible for acute haemolysis following exposure to oxidative stress. Drugs which induce haemolysis in these patients are often used in anaesthesia and perioperative pain management. Neurosurgery and few drugs routinely used during these procedures are known to cause stress situations. Associated infection and certain foodstuffs are also responsible for oxidative stress. Here, we present two patients with G-6-PD deficiency who underwent uneventful neurosurgical procedures. The anaesthetic management in such patients should focus on avoiding the drugs implicated in haemolysis, reducing the surgical stress with adequate analgesia, and monitoring for and treating the haemolysis, should it occur