a smartwatch step counter for slow and intermittent ambulation

The ambulatory monitoring of human movement can provide valuable information regarding the degree of functional ability and general level of activity of individuals. Since walking is a basic everyday movement, automatic step detection or step counting is very important in developing ambulatory monitoring systems. This paper is concerned with the development and the preliminary validation of a step counter (SC) designed to operate also in conditions of slow and intermittent ambulation. The SC was based on processing the accelerometer data measured by a Gear 2 smartwatch running a custom wearable app, named ADAM. A data set of eight users, for a total of 80 trials, was used to tune ADAM. Finally, ADAM was compared with two different commercial SCs: the native SC running on the Gear 2 smart watch and a waist-worn SC, the Geonaute ONSTEP 400. A second data set of eight additional users for a total of 80 trials was used for the assessment study. The three SCs performed quite similarly in conditions of normal walking over long paths (1%–3% of mean absolute relative error); ADAM outperformed the two other SCs in conditions of slow and intermittent ambulation; the error incurred by ADAM was limited to 5%, which is significantly lower than errors of 20%–30% incurred by the two other SCs

Hymenoptera Venom Immunotherapy: Tolerance and Efficacy of an Ultrarush Protocol versus a Rush and a Slow Conventional Protocol

Background and Objective. Various venom immunotherapy (VIT) protocols are available for Hymenoptera allergy. Although adverse reactions (ADRs) to VIT are widely reported, controlled trials are still needed. We conducted a randomized prospective study to evaluate ADRs and the efficacy of three VIT regimens. Methods. 76 patients with Hymenoptera allergy, aged 16–76 years, were randomized to receive an ultrarush protocol (group A: 27 patients), a rush protocol (group B: 25), or a slow protocol (group C: 24). Aqueous venom extract was used in incremental phase and an adsorbed depot in maintenance phase. ADRs and accidental Hymenoptera stings during VIT were used to evaluate efficacy. Results. During incremental treatment, ADRs occurred in 1.99%, 3.7%, and 3.9% of patients in groups A, B, and C, and in 0.99%, 1.46%, and 2.7%, respectively, during maintenance. ADRs were significantly fewer in group A (incremental + maintenance phase) than in group C (1.29% versus 3.2%; P = 0.013). Reactions to accidental Hymenoptera stings did not differ among groups (1.1%, 1.2%, and 1.1%). Conclusion. Ultrarush was as effective as the rush and slow protocols and was associated with a low incidence of reactions to stings. This study indicates that ultrarush VIT is a valid therapeutic option for Hymenoptera allergy

Estimation of Vehicle Longitudinal Velocity with Artificial Neural Network

Vehicle dynamics control systems have a fundamental role in smart and autonomous mobility, where one of the most crucial aspects is the vehicle body velocity estimation. In this paper, the problem of a correct evaluation of the vehicle longitudinal velocity for dynamic control applications is approached using a neural networks technique employing a set of measured samples referring to signals usually available on-board, such as longitudinal and lateral acceleration, steering angle, yaw rate and linear wheel speed. Experiments were run on four professional driving circuits with very different characteristics, and the vehicle longitudinal velocity was estimated with different neural network training policies and validated through comparison with the measurements of the one acquired at the vehicle’s center of gravity, provided by an optical Correvit sensor, which serves as the reference (and, therefore, exact) velocity values. The results obtained with the proposed methodology are in good agreement with the reference values in almost all tested conditions, covering both the linear and the nonlinear behavior of the car, proving that artificial neural networks can be efficiently employed onboard, thereby enriching the standard set of control and safety-related electronics

Geographical Distribution Characteristics of Ethnic-Minority Villages in Fujian and Their Relationship with Topographic Factors

The geographical distribution characteristics of villages characterised by ethnic minorities are determined by the selection of the site when the village was initially established. The location of inherited and well-preserved minority villages must be exceptionally compatible with the natural terrain, with a logical relationship. Nonetheless, the issue of village location, which is directly related to the development of the features of the geographical distribution, has received little attention from scholars. The average nearest proximity index, Voronoi, kernel density analysis, proximity analysis, and the Geographical Detector (GeoDetector) were used to analyse the geographic distribution characteristics of villages and their correlation with terrain, as well as the difference between the influence of each terrain factor. The findings indicated the following. (1) The geographical distribution of minority villages in Fujian Province is of the agglomeration type, with a significant “mononuclear” feature, and the topography has a facilitating effect on the clustering distribution of villages. (2) The geographical distribution of minority villages in each city of Fujian Province coexisted with the agglomeration type and the dispersion type, and the role of topography in promoting the agglomeration-type distribution of villages was not affected by the distribution density of villages. (3) The site selection of Fujian-minority villages is characterised by medium altitude, moderate slope, sun exposure, and no obvious hydrophilicity. Minority villages are mainly located in areas with an elevation of 202–647 m; a slope of 6–15°; a flat land aspect with a south slope, southeast slope, or southwest slope; and distance of 500–1500 m from 5–20 m wide rivers of level 2. (4) The site selection of Fujian minority villages is influenced by various topographic factors, such as elevation, slope, aspect, river buffer, river width, and river level, among which river width has the most substantial effect. (5) All topographic factors have a two-factor enhancing relationship with each other, aspect and slope have the most substantial effect and play a dominant role in site selection. The research findings illuminate the internal logic of the geographical distribution differentiation of villages characterised by ethnic minorities, which is critical for promoting the protection of modern ethnic-minority villages

Effect of a fixed combination of nimodipine and betahistine versus betahistine as monotherapy in the long-term treatment of M\ue9ni\ue8re's disease: a 10-year experience

Despite an abundance of long-term pharmacological treatments for recurrent vertigo attacks due to M\ue9ni\ue8re's disease, there is no general agreement on the their efficacy. We present the results of a retrospective study based on a 10-year experience with two long-term medical protocols prescribed to patients affected by M\ue9ni\ue8re's disease (diagnosed according to the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium guidelines) who completed treatments in the period 1999-2009. A total of 113 medical records were analysed; 53 patients received betahistine-dihydrochloride at on-label dosage (32 mg die) for six months, and 60 patients were treated with the same regimen and nimodipine (40 mg die) as an add-therapy during the same period. Nimodipine, a 1,4-dihydropyridine that selectively blocks L-type voltage-sensitive calcium channels, has previously been tested as a monotherapy for recurrent vertigo of labyrinthine origin in a multinational, double-blind study with positive results. A moderate reduction of the impact of vertigo on quality of life (as assessed by the Dizziness Handicap Inventory) was obtained in patients after therapy with betahistine (p 0.05), whereas the fixed combination of betahistine and nimodipine was associated with a significant reduction of tinnitus annoyance and improvement of hearing loss (p < 0.005). It was concluded that nimodipine represents not only a valid add-therapy for M\ue9ni\ue8re's disease, and that it may also exert a specific effect on inner ear disorders. Further studies to investigate this possibility are needed

A Low-Temperature and Low-Pressure Distillation Plant for Dairy Wastewater

The paper investigates an alternative treatment plant for the typical wastewater effluent of a cheese-making industry, mainly composed of acid or sweet whey mixed with washing water. Two variable parameters have been considered during the tests: four treatment temperatures (39, 46, 53 and 60 °C) and three solid content values (30%, 50% and 70%) of the concentrated product. The minimum and maximum values of the removal efficiency (pollutant amount into concentrate related to raw whey) range from 94.6% to 97.7% for conductivity, from 98.3% to 99.5% for BOD5, from 98.7% to 99.6% for COD and from 98.2% to 99.3% for Total Nitrogen. The plant capacity ranges from about 2 L/h (at 39 °C) to 6 L/h (at 60 °C) of processed whey. On the basis of the experimental findings, the proposed purification technology has demonstrated its suitability both to purify the effluent wastewater and to recover high-quality products (e.g., whey protein concentrate, lactose), thanks to its low thermal damage on the treated product and to its relatively low energy consumption from 0.4 kWh/L (at 60 °C) to 1.0 kWh/L (at 39 °C) of processed whey, with a Coefficient of Performance from approximately 0.6 up to 1.5

Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism

Introduction: Hypogonadotropic hypogonadism (HH) is a heterogeneous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distin- guished into Kallmann syndrome (KS) and isolated HH. The prevalence of other develop- mental anomalies is not well established. Methods: We studied 36 patients with HH (31 males, 5 females, mean age 41.5), 9 with familial and 27 with sporadic HH (33 congenital, 3 adult-onset), by physical examination, smell test (BSIT Sensonics), audiometry, renal ultrasound, and magnetic resonance imag- ing of the olfactory structures. Results: Based on the smell test, patients were classified as normosmic (n = 21, 58.3%) and hypo/anosmic (n = 15, 41.6%). Hypoplasia/agenesis of olfactory bulbs was found in 40% of patients (10/25; 75% hypo/anosmic, 7.6% normosmic, p<0.01, Fisher’s test). Remarkably, olfactory structures were normal in two anosmic patients, while one nor- mosmic patient presented a unilateral hypoplastic bulb. Fourteen of 33 patients (42.4%) presented neurosensorial hearing loss of various degrees (28.5% hypo/anosmic, 52.6% normosmic, p=NS). Renal ultrasound revealed 27.7% of cases with renal anomalies (26.6% hypo/anosmic, 28.5% normosmic, p = NS). At least one midline defect was found in 50% of the patients (53.3% hypo/anosmic, 47.6% normosmic, p = NS), including abnor- mal palate, dental anomalies, pectus excavatum, bimanual synkinesis, iris coloboma, and absent nasal cartilage. Anamnestically 4/31 patients reported cryptorchidism (25% hypo/anosmic, 5.2% normosmic, p = NS). Conclusion: Hypo/anosmia is significantly related to anatomical anomalies of the olfac- tory bulbs/tracts but the prevalence of other developmental anomalies, especially midline defects and neurosensorial hearing loss, is high both in HH and KS and independent of the presence of anosmia/hyposmia. From the clinical standpoint KS and normosmic HH should be considered as the same complex, developmental disease

Heavy quarks in charged-current deep inelastic scattering: a systematic phenomenological study

We present a systematic QCD analysis of the strange--charm and bottom--top contributions to transverse and longitudinal structure functions in charged--current deep inelastic scattering. Various ${\cal O}(\alpha_s^1)$ schemes are studied and compared. The dependence of their predictions on the factorization scale $\mu^2$ is investigated. The theoretical uncertainties resulting from the choice of the scheme and of $\mu^2$ are estimated.Comment: 9 page