5 research outputs found
The role of nuclear weapons in France : a study of the political uses and of the security purposes of the French nuclear deterrent
Only abstract. Paper copies of master’s theses are listed in the Helka database (http://www.helsinki.fi/helka). Electronic copies of master’s theses are either available as open access or only on thesis terminals in the Helsinki University Library.Vain tiivistelmä. Sidottujen gradujen saatavuuden voit tarkistaa Helka-tietokannasta (http://www.helsinki.fi/helka). Digitaaliset gradut voivat olla luettavissa avoimesti verkossa tai rajoitetusti kirjaston opinnäytekioskeilla.Endast sammandrag. Inbundna avhandlingar kan sökas i Helka-databasen (http://www.helsinki.fi/helka). Elektroniska kopior av avhandlingar finns antingen öppet på nätet eller endast tillgängliga i bibliotekets avhandlingsterminaler.This is a study of the role of nuclear weapons in France during and after the Cold War. To understand the significance attributed to the nuclear deterrent, one must understand the philosophy behind French nuclear politics, which is based on France’s views about the world order and her own stand in this world. The aim of the study is to determine how the changes in world order in the 1990’s have affected the political uses and the security purposes of the French nuclear deterrent. The study compares the political and military roles attributed to nuclear weapons when they were originally developed during the 1960s, to the purpose the French deterrent had acquired by the 1990’s. Military aspects of the nuclear force are determined through examination of the French nuclear doctrine and nuclear hardware, where as political aspects are deduced from the speeches and articles written by French analysts and politicians concerning the nuclear deterrent. Special attention is given to France's NATO relations, because this relationship often culminated in nuclear issues. French nuclear weapons had an important security function both during and after the Cold War. In the 1960’s nuclear weapons also served as a means of ensuring freedom of action, and as an element of prestige within the international community. By the 1990’s, nuclear weapons no longer fulfil these political functions. This can be explained by a change in the nature of power, as the significance of military power as an element of political influence has decreased to the benefit of economic issues. To remain an influential power, France needs to be at the steering groups of the main international economic, military and political entities. The nuclear tests in the Mururoa Atolls can be interpreted as signalling to the world that that France intends to retain its nuclear deterrent at a credible level for national defensive purposes – and perhaps, in the future, also for the benefit of common European security
Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.Peer reviewe