Reasons to Care about Reasons for Action: A Response to Paul S. Davies

In eschewing the specialty-standards of neuro-babble and philosophical neologism, Paul S. Davies (2016) argues with courageous clarity. He connects issues in neuroscience and epistemology to problems surrounding agency. I agree with many of his claims, but I think they need more context and precision for application. This is because his argument as it stands now affects only a limited set of theories, and a hidden modality in thesis 3 tempers his argument further. And perhaps most urgently, if his theory fails to address “top-down”1 mental processes or social dimensions of knowledge, his argument fails to meet even his own goals set out in the paper

Health inequalities and development plans in Iran: An analysis of the past three decades (1984–2010)

Introduction: Reducing inequalities in health care is one of the main challenges in all countries. In Iran as in other oil-exporting upper middle income countries, we expected to witness fewer inequalities especially in the health sector with the increase in governmental revenues. Methods: This study presents an inequalities assessment of health care expenditures in Iran. We used data from the Household Income and Expenditure Survey (HIES) in Iran from 1984–2010. The analysis included 308,735 urban and 342,532 rural households. Results: The results suggest heightened inequality in health care expenditures in Iran over the past three decades, including an increase in the gap between urban and rural areas. Furthermore, inflation has affected the poor more than the rich. The Kakwani progressivity index in all years is positive, averaging 0.436 in rural and 0.470 in urban areas during the time period of analysis. Compared to inequality in income distribution over the last 30 years, health expenditures continuously show more inequality and progressivity over the same period of time. Conclusions: According to the result of our study, during this period Iran introduced four National Development Plans (NDPs); however, the NDPs failed to provide sustainable strategies for reducing inequalities in health care expenditures. Policies that protect vulnerable groups should be prioritized

Discovery of Temperate Latitude Clouds on Titan

Until now, all the clouds imaged in Titan's troposphere have been found at far southern latitudes (60°-90° south). The occurrence and location of these clouds is thought to be the result of convection driven by the maximum annual solar heating of Titan's surface, which occurs at summer solstice (2002 October) in this south polar region. We report the first observations of a new recurring type of tropospheric cloud feature, confined narrowly to ~40° south latitude, which cannot be explained by this simple insolation hypothesis. We propose two classes of formation scenario, one linked to surface geography and the other to seasonally evolving circulation, which will be easily distinguished with continued observations over the next few years

Exploring the evolutionary paths of the most massive galaxies since z~2

We use Spitzer MIPS data from the FIDEL Legacy Project in the Extended Groth Strip to analyze the stellar mass assembly of massive (M>10^11 M_sun) galaxies at z<2 as a function of structural parameters. We find 24 micron emission for more than 85% of the massive galaxies morphologically classified as disks, and for more than 57% of the massive systems morphologically classified as spheroids at any redshift, with about 8% of sources harboring a bright X-ray and/or infrared emitting AGN. More noticeably, 60% of all compact massive galaxies at z=1-2 are detected at 24 micron, even when rest-frame optical colors reveal that they are dead and evolving passively. For spheroid-like galaxies at a given stellar mass, the sizes of MIPS non-detections are smaller by a factor of 1.2 in comparison with IR-bright sources. We find that disk-like massive galaxies present specific SFRs ranging from 0.04 to 0.2 Gyr^-1 at z<1 (SFRs ranging from 1 to 10 M_sun/yr), typically a factor of 3-6 higher than massive spheroid-like objects in the same redshift range. At z>1, and more pronouncedly at z>1.3, the median specific SFRs of the disks and spheroids detected by MIPS are very similar, ranging from 0.1 to 1 Gyr^-1 (SFR=10-200 M_sun/yr). We estimate that massive spheroid-like galaxies may have doubled (at the most) their stellar mass from star-forming events at z<2: less than 20% mass increase at 1.7<z<2.0, up to 40% more at 1.1<z<1.7, and less than 20% additional increase at z<1. Disk-like galaxies may have tripled (at the most) their stellar mass at z<2 from star formation alone: up to 40% mass increase at 1.7<z<2.0, and less than 180% additional increase below z=1.7 occurred at a steady rate.Comment: Accepted for publication in ApJ; 10 pages, 5 figures, 1 tabl

Direct measurement of the size of 2003 UB313 from the Hubble Space Telescope

We have used the Hubble Space Telescope to directly measure the angular size of the large Kuiper belt object 2003 UB313. By carefully calibrating the point spread function of a nearby field star, we measure the size of 2003 UB313 to be 34.3$\pm$1.4 milliarcseconds, corresponding to a diameter of 2400$\pm$100 km or a size $\sim5$% larger than Pluto. The V band geometric albedo of 2003 UB313 is $86\pm7$%. The extremely high albedo is consistent with the frosty methane spectrum, the lack of red coloring, and the lack of observed photometric variation on the surface of 2003 UB313. Methane photolysis should quickly darken the surface of 2003 UB313, but continuous evaporation and redeposition of surface ices appears capable of maintaining the extreme alebdo of this body

The influence of coronal EUV irradiance on the emission in the He I 10830 A and D3 multiplets

Two of the most attractive spectral windows for spectropolarimetric investigations of the physical properties of the plasma structures in the solar chromosphere and corona are the ones provided by the spectral lines of the He I 10830 A and 5876 A (or D3) multiplets, whose polarization signals are sensitive to the Hanle and Zeeman effects. However, in order to be able to carry out reliable diagnostics, it is crucial to have a good physical understanding of the sensitivity of the observed spectral line radiation to the various competing driving mechanisms. Here we report a series of off-the-limb non-LTE calculations of the He I D3 and 10830 A emission profiles, focusing our investigation on their sensitivity to the EUV coronal irradiation and the model atmosphere used in the calculations. We show in particular that the intensity ratio of the blue to the red components in the emission profiles of the He I 10830 A multiplet turns out to be a good candidate as a diagnostic tool for the coronal irradiance. Measurements of this observable as a function of the distance to the limb and its confrontation with radiative transfer modeling might give us valuable information on the physical properties of the solar atmosphere and on the amount of EUV radiation at relevant wavelengths penetrating the chromosphere from above.Comment: 19 pages, 11 figures (pre-print format). Accepted for publication in Ap

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients

© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes and fibroblasts) derived from FA patients of the FA-D2 complementation group, which provides a more accurate physiological assessment than is possible with transformed cells or animal models. Results: We analyzed telomere length, telomere dysfunction-induced foci (TIFs), sister chromatid exchanges (SCE), telomere sister chromatid exchanges (T-SCE), apoptosis and expression of shelterin components TRF1 and TRF2. FANCD2 lymphocytes exhibited multiple types of telomeric abnormalities, including premature telomere shortening, increase in telomeric recombination and aberrant telomeric structures ranging from fragile to long-string extended telomeres. The baseline incidence of SCE in FANCD2 lymphocytes was reduced when compared to control, but in response to diepoxybutane (DEB) the 2-fold higher rate of SCE was observed. In contrast, control lymphocytes showed decreased SCE incidence in response to DEB treatment. FANCD2 fibroblasts revealed a high percentage of TIFs, decreased expression of TRF1 and invariable expression of TRF2. The percentage of TIFs inversely correlated with telomere length, emphasizing that telomere shortening is the major reason for the loss of telomere capping function. Upon irradiation, a significant decrease of TIFs was observed at all recovery times. Surprisingly, a considerable percentage of TIF positive cells disappeared at the same time when incidence of γ-H2AX foci was maximal. Both FANCD2 leucocytes and fibroblasts appeared to die spontaneously at higher rate than control. This trend was more evident upon irradiation; the percentage of leucocytes underwent apoptosis was 2.59- fold higher than that in control, while fibroblasts exhibited a 2- h delay before entering apoptosis. Conclusion: The results of our study showed that primary cells originating from FA-D2 patients display shorten telomeres, elevated incidence of T-SCEs and high frequency of TIFs. Disappearance of TIFs in early response to irradiation represent distinctive feature of FANCD2 cells that should be examined further.This article is made available through the Brunel Open Access Publishing Fund. This work was supported by the Ministry of Education and Science of the Republic of Serbia (Project No.173046)