Precocious Utilisation at Reproduction of Female Youth Sheep From Ţigaie Breed

Ovine rearing represents a domain being in a full development process in Romania. At the base of this tendency are the solicitation of local and external markets for basic production, respectively meat and milk. To record favourable economical results farmers wants to apply the most optimal technologies so, economical efficiency to reach a maximum level for each female which is part of the livestock (Pascal, 2015, Daraban  2006 ). One of those technologies refers also at precocious utilisation at reproduction of a female youth. So, the aim of effectuated research was represented by studying of possibilities for utilization at reproduction of female youth at an age still from the first year of life.Biologic material was represented by domestic ovine, from Ţigaie breed, reared in different farms situated in the North-East part of Romania. Experimental batches were formed by females with different ages, but all of them being utilized for the first time at mating. Respecting those demands were formed three batches differentially by age between them, which had, at the moment of utilization for reproduction, 9 months (L1), 18 months (L2) and 22 months (L3). Control batch was formed by adult females belonging to the same breed (LM). In the current research were tracked more aspects, the most important being the ones in which were analyzed the influence of sheep’ age on specific indexes of reproduction function, on the total duration of gestation and on further corporal development of youth females. The obtained data were statistically processed using ANOVA software, and for determination of differences and their signification were utilized Fisher and Tukey tests. The obtained results allow us to enlightened the fact that even, in case of batches formed by female youth, the mean values for studied parameters were very close to the ones specific to adult sheep, differences are significant in majority of situations for p >0.01

Revascularization impact: quality of life enhancement in chronic limb-threatening ischemia

Introduction. Globally, over 230 million people have peripheral artery disease, often undiagnosed, leading to chronic limb-threatening ischemia. Revascularization is vital for preventing amputation and improving quality of life. While specific questionnaires for severe ischemia are lacking, the SF-36 questionnaire is widely used to assess quality of life, with variations like SF-12 and SF-8 for larger cohorts. Objectives. Our aim was to assess how different lower limb revascularization methods affect the postoperative quality of life in patients with chronic limb-threatening ischemia. Methods. This study was conducted at the St. Pantelimon Emergency Hospital of Bucharest, Romania. It included 166 adult patients with chronic limb-threatening ischemia who were monitored for 12 months. Quality of life was assessed using the SF-36 questionnaire. The patients were categorized into two groups: 112 underwent conventional surgery, and 54 had hybrid procedures. Data analysis involved t-tests, Mann-Whitney U tests and assessment of data reliability. Results. In the Conventional Surgery group, the average age was 70.5 years, predominantly male, with similar risk factors as the second group. The Hybrid Surgery group had an average age of 73 and exhibited more extensive distal arterial lesions, higher rates of ulcer/gangrene, and a higher occurrence of postoperative minor amputations. The SF-36 questionnaire showed low data reliability for the General Health and Social Functioning domains. Additionally, the Hybrid Surgery group had poorer preoperative perception in the Body Pain category. However, significant postoperative improvements in quality of life were observed in all domains for both groups with similar results. Conclusions. Revascularization improves the quality of life for patients with chronic limb-threatening ischemia, including those that also require minor amputations. SF-36 has good assessment for most QoL aspects, but reliability declines in severe ischemia

Advantages of total parathyroidectomy in patients with secondary hyperparathyroidism induced by end stage renal disease

IntroductionSecondary hyperparathyroidism, as a result of chronic kidney disease could be treated medically or surgically. When pharmacotherapy fails, patients undergo surgery - parathyroidectomy, the curative treatment of secondary hyperparathyroidism (SHPT). There are currently 3 accepted surgical techniques, each with supporters or opponents – total parathyroidectomy, subtotal parathyroidectomy and parathyroidectomy with immediate autotransplantation.MethodsIn this paper we described our experience on a series of 160 consecutive patients diagnosed with secondary hyperparathyroidism who underwent surgery, in 27 cases it was totalization of the intervention (patients with previously performed subtotal parathyroidectomy or with supernumerary glands and SHPT recurrence). We routinely perform total parathyroidectomy, the method that we believe offers the best results. ResultsThe group of patients was studied according to demographic criteria, paraclinical balance, clinical symptomatology, pre- and postoperative iPTH (intact parathormone) values, SHPT recurrence, number of reinterventions. In 31 cases we found gland ectopy and in 15 cases we discovered supernumerary parathyroids. A percentage of 96.24% of patients with total parathyroidectomy did not show recurrence.DiscussionsAfter analyzing the obtained results, our conclusion was that total parathyroidectomy is the intervention of choice for patients suffering from secondary hyperparathyroidism when pharmacotherapy fails in order to prevent recurrence of the disease and to correct the metabolic parameters

Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019

Background: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10–24 years during the past three decades. Methods: Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10–14, 15–19, and 20–24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings: In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31·1 million DALYs (of which 16·2 million [52%] were transport related) among adolescents aged 10–24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34·4% (from 17·5 to 11·5 per 100 000) for transport injuries, and by 47·7% (from 15·9 to 8·3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80·5% to 42 774 for transport injuries and by 39·4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010–19, the rate per 100 000 of transport injury DALYs was reduced by 16·7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48·5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0·2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010–19. Interpretation: As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low–middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding: Bill & Melinda Gates Foundation

Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10-24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We report trends in estimated total numbers of deaths and mortality rate per 100 000 population in young people aged 10-24 years by age group (10-14 years, 15-19 years, and 20-24 years) and sex in 204 countries and territories between 1950 and 2019 for all causes, and between 1980 and 2019 by cause of death. We analyse variation in outcomes by region, age group, and sex, and compare annual rate of change in mortality in young people aged 10-24 years with that in children aged 0-9 years from 1990 to 2019. We then analyse the association between mortality in people aged 10-24 years and socioeconomic development using the GBD Socio-demographic Index (SDI), a composite measure based on average national educational attainment in people older than 15 years, total fertility rate in people younger than 25 years, and income per capita. We assess the association between SDI and all-cause mortality in 2019, and analyse the ratio of observed to expected mortality by SDI using the most recent available data release (2017). Findings In 2019 there were 1.49 million deaths (95% uncertainty interval 1.39-1.59) worldwide in people aged 10-24 years, of which 61% occurred in males. 32.7% of all adolescent deaths were due to transport injuries, unintentional injuries, or interpersonal violence and conflict; 32.1% were due to communicable, nutritional, or maternal causes; 27.0% were due to non-communicable diseases; and 8.2% were due to self-harm. Since 1950, deaths in this age group decreased by 30.0% in females and 15.3% in males, and sex-based differences in mortality rate have widened in most regions of the world. Geographical variation has also increased, particularly in people aged 10-14 years. Since 1980, communicable and maternal causes of death have decreased sharply as a proportion of total deaths in most GBD super-regions, but remain some of the most common causes in sub-Saharan Africa and south Asia, where more than half of all adolescent deaths occur. Annual percentage decrease in all-cause mortality rate since 1990 in adolescents aged 15-19 years was 1.3% in males and 1.6% in females, almost half that of males aged 1-4 years (2.4%), and around a third less than in females aged 1-4 years (2.5%). The proportion of global deaths in people aged 0-24 years that occurred in people aged 10-24 years more than doubled between 1950 and 2019, from 9.5% to 21.6%. Interpretation Variation in adolescent mortality between countries and by sex is widening, driven by poor progress in reducing deaths in males and older adolescents. Improving global adolescent mortality will require action to address the specific vulnerabilities of this age group, which are being overlooked. Furthermore, indirect effects of the COVID-19 pandemic are likely to jeopardise efforts to improve health outcomes including mortality in young people aged 10-24 years. There is an urgent need to respond to the changing global burden of adolescent mortality, address inequities where they occur, and improve the availability and quality of primary mortality data in this age group. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd

Animal Models in Bladder Cancer

Background: Bladder cancer (urothelial cancer of the bladder) is the most common malignancy affecting the urinary system with an increasing incidence and mortality. Mouse models of bladder cancer should possess a high value of reproducibility, predictability, and translatability to allow mechanistic, chemo-preventive, and therapeutic studies that can be furthered into human clinical trials. Objectives: To provide an overview and resources on the origin, molecular and pathological characteristics of commonly used animal models in bladder cancer. Methods: A PubMed and Web of Science search was performed for relevant articles published between 1980 and 2021 using words such as: “bladder” and/or “urothelial carcinoma” and animal models. Animal models of bladder cancer can be categorized as autochthonous (spontaneous) and non-autochthonous (transplantable). The first are either chemically induced models or genetically engineered models. The transplantable models can be further subclassified as syngeneic (murine bladder cancer cells implanted into immunocompetent or transgenic mice) and xenografts (human bladder cancer cells implanted into immune-deficient mice). These models can be further divided—based on the site of the tumor—as orthotopic (tumor growth occurs within the bladder) and heterotopic (tumor growth occurs outside of the bladder)

THE EFFECT OF APPLIED CROSSBREEDING ON INCREASING OF MILK PRODUCTION IN SHEEP

The aim of the research was to identify new methods to increase milk production insheep. An evaluation of milk production at Ţigaie local breed, in comparison withhalf-breed females from crossbreeding of local breed sheep with Awassi rams (Awx Ti) and with Lacaune (La x Ti) was conducted. Estimation of milk productionwas done according to given by International Committee for Animal Recording(AT method) and statistical analysis was performed using the Restricted MaximumLikelihood method. Mean milk production in Aw x Tiewes was 29, 28% higherthan in local breed Ţigaie, and 32. 20% higher than in La x Ti ewes. Differences ofmilk yield found in three groups of animals were very significant (p<0. 001). Basedon obtained results it could be concluded that crossbreeding of Ţigaie with Awassibreed rams had a better effect on increasing of milk production than crossbreedingwith Lacaune breed rams

Determination of the critical points in solid-state phase transformation of some hypoeutectoid steels

This study allowed, by dilatometric analyses, both to highlight the solid state transformations that occurred during the continuous heating of two hypoeutectoid steels, as well as to investigate the effect of the heating rate on the critical points at which these transformations occurred. The eutectoid transformation (the pearlite dissolution into austenite) was carried out in a temperatures interval, ranging between pearlite dissolution start temperature (Ac1) and pearlite dissolution finish temperature (denoted Acfp in this article). Increasing the heating rate determined a displacement of the critical points in solid-state phase transformation to higher temperatures; these displacements were more significant for the Acfp point, than for the critical points Ac1 and Ac3

The Role of Prostate-Specific Antigen in Prostate Cancer Screening

Cancerul de prostată reprezintă, după cancerul pulmonar, cea mai frecventă afecţiune malignă diagnosticată în cadrul populaţiei masculine. Introducerea în practica curentă în anii 80-90 a determinării Antigenului Specific al Prostatei (PSA) seric, ca şi componentă a screeningului pentru cancerul de prostată, a reprezentat un moment de răscruce în practica medicală. Datorită acestei enzime produsă exclusiv de către glanda prostatică, rata detecţiei cancerului de prostată (în stadii curative, intracapsulare) s-a îmbunătăţit semnificativ. PSA - ul seric reprezintă un factor predictiv pentru cancerul de prostată (CP) mai bun decât tuşeul rectal sau ecografia prostatică transrectal

Sentinel-1 Data for Underground Processes Recognition in Bucharest City, Romania

Urban areas are strongly influenced by the different processes affecting the underground and implicitly the terrestrial surface. Land subsidence can be one of the effects of the urban processes. The identification of the vulnerable areas of the city, prone to subsidence, can be of great help for a sustainable urban planning. Using Sentinel-1 data, by the PSI (persistent scatterer interferometry) technique, a vertical displacements map of Bucharest city has been prepared. It covers the time interval 2014&ndash;2018. Based on this map, several subsidence areas have been identified. One of them, holding a thick layer of debris from urban constructions, was analyzed in detail, on the basis of an accurate local geological model and by correlating the local displacements with the urban groundwater system hydraulic heads. The properties of the anthropogenic layer have been characterized by complementary geotechnical and hydrogeological studies. A dynamic instability pattern, highlighted by PSI results, has been put into evidence when related to this type of anthropogenic layer. This thick anthropogenic layer and its connections to the urban aquifer system have to be further analyzed, when the procedures of urban planning and design invoke constructive operations modifying the aquifer dynamics