Predictors of the Response to Tolvaptan Therapy and Its Effect on Prognosis in Cirrhotic Patients with Ascites

Aims: The vasopressin V2 receptor antagonist, tolvaptan, has been reported to be effective in cirrhotic patients with ascites. Here, we evaluated predictors of the response to tolvaptan. Methods: A total of 97 patients with cirrhosis (60 males; median age, 63 years) who had been treated for ascites with oral tolvaptan were enrolled. Tolvaptan efficacy was defined as urine volume increase of ≥500 mL or a urine volume ≥2000 mL/day on the day following treatment. Normalization of the serum sodium (Na) level after 1 week of treatment and the posttreatment survival rate was analyzed. Results: Tolvaptan therapy resulted in effective urination in 67% of patients. A multivariate analysis revealed that the blood urea nitrogen/creatinine (BUN/Cr) ratio and urinary Na/potassium (Na/K) ratio were predictive of the tolvaptan response (p <0.05). The serum Na level was 135 (121–145) mEq/L, and normal levels were recovered in 50.0% of the patients with an initial Na level of <135 mEq/L. The posttreatment survival rate was significantly higher in patients who responded to tolvaptan therapy (p <0.05). Conclusions: The combination of the initial BUN/Cr and urine Na/K ratios and a normalized serum Na level after 1 week was predictive of a favorable outcome to tolvaptan therapy

High Excitation Molecular Gas in the Galactic Center Loops; 12CO(J =2-1 and J =3-2) Observations

We have carried out 12CO(J =2-1) and 12CO(J =3-2) observations at spatial resolutions of 1.0-3.8 pc toward the entirety of loops 1 and 2 and part of loop 3 in the Galactic center with NANTEN2 and ASTE. These new results revealed detailed distributions of the molecular gas and the line intensity ratio of the two transitions, R3-2/2-1. In the three loops, R3-2/2-1 is in a range from 0.1 to 2.5 with a peak at ~ 0.7 while that in the disk molecular gas is in a range from 0.1 to 1.2 with a peak at 0.4. This supports that the loops are more highly excited than the disk molecular gas. An LVG analysis of three transitions, 12CO J =3-2 and 2-1 and 13CO J =2-1, toward six positions in loops 1 and 2 shows density and temperature are in a range 102.2 - 104.7 cm-3 and 15-100 K or higher, respectively. Three regions extended by 50-100 pc in the loops tend to have higher excitation conditions as characterized by R3-2/2-1 greater than 1.2. The highest ratio of 2.5 is found in the most developed foot points between loops 1 and 2. This is interpreted that the foot points indicate strongly shocked conditions as inferred from their large linewidths of 50-100 km s-1, confirming the suggestion by Torii et al. (2010b). The other two regions outside the foot points suggest that the molecular gas is heated up by some additional heating mechanisms possibly including magnetic reconnection. A detailed analysis of four foot points have shown a U shape, an L shape or a mirrored-L shape in the b-v distribution. It is shown that a simple kinematical model which incorporates global rotation and expansion of the loops is able to explain these characteristic shapes.Comment: 59 pages, accepted to PAS

Temperature and Density in the Foot Points of the Molecular Loops in the Galactic Center; Analysis of Multi-J Transitions of 12CO(J=1-0, 3-2, 4-3, 7-6), 13CO(J=1-0) and C18O(J=1-0)

Fukui et al. (2006) discovered two molecular loops in the Galactic center and argued that the foot points of the molecular loops, two bright spots at both loops ends, represent the gas accumulated by the falling motion along the loops, subsequent to magnetic flotation by the Parker instability. We have carried out sensitive CO observations of the foot points toward l=356 deg at a few pc resolution in the six rotational transitions of CO; 12CO(J=1-0, 3-2, 4-3, 7-6), 13CO(J=1-0) and C18O(J=1-0). The high resolution image of 12CO (J=3-2) has revealed the detailed distribution of the high excitation gas including U shapes, the outer boundary of which shows sharp intensity jumps accompanying strong velocity gradients. An analysis of the multi-J CO transitions shows that the temperature is in a range from 30-100 K and density is around 10^3-10^4 cm^-3, confirming that the foot points have high temperature and density although there is no prominent radiative heating source such as high mass stars in or around the loops. We argue that the high temperature is likely due to the shock heating under C-shock condition caused by the magnetic flotation. We made a comparison of the gas distribution with theoretical numerical simulations and note that the U shape is consistent with numerical simulations. We also find that the region of highest temperature of ~100 K or higher inside the U shape corresponds to the spur having an upward flow, additionally heated up either by magnetic reconnection or bouncing in the interaction with the narrow neck at the bottom of the U shape. We note these new findings further reinforce the magnetic floatation interpretation.Comment: 40 pages, 23 figures, accepted by PASJ on Vol.62 No.

Superhump Evolution in the Ultrashort Period Dwarf Nova 1RXS J232953.9+062814

Abstract We report on the evolution of superhumps and late superhumps in an ultrashort period dwarf nova, 1RXS J232953.9$+$062814, during the superoutburst in 2001 November. Ordinary superhumps were observed throughout a plateau phase, a rapid fading phase, and a rebrightening phase. During the plateau phase, the superhump period increased with time at a large rate of $P_\mathrm{dot} = 1.19 \pm 0.24 \times 10^{-4}$. In conjunction with the rebrightening phenomenon, these characteristics indicate that an accretion disk expanded further outward from the $3:1$ resonance radius, which caused a large amount of left over matter at the outer disk, even after the superoutburst. In the post-outburst phase, we detected late superhumps superimposed on dominant double-peak modulations. Late superhumps were observed at least for 10 d without a significant period change. We detected the first normal outburst of this object on 2001 December 26. The interval between the superoutburst and this normal one is 53 d. This short recurrence time supports a high mass-transfer rate in this system. Concerning the evolutionary status of 1RXS J232953.9$+$062814, we propose that it is a progenitor of AM CVn stars on the evolutionary course of the cataclysmic variable channel in which systems have a secondary star with a hydrogen-exhausted core

Monitor of All-sky X-ray Image (MAXI)

Abstract. Monitor of All-sky X-ray Image (MAXI) is the first astrophysical payload which will be mounted on the Japanese Experiment Module (JEM) Exposed Facility in 2004. It is an X-ray all-sky monitor with unprecedented sensitivity to watch the activities of the X-ray sources in the whole sky in every 90 minutes. MAXI is boxshaped in 0.8 x 1.0 x 1.85 m with the weight of 500 kg. The mission life will be at least 2 years. MAXI has two fan-like field of views (FOV), 160 x 1.5 degree each. The X-ray instruments are Gas Slit Camera (GSC) and Solid-state Slit Camera (SSC). The GSC uses gas one-dimensional position sensitive proportional counters with 5340 cm 2 effective area in total and the SSC uses CCDs with 200 cm 2 . Both are capable to detect one-dimensional image, which is used to obtain the locations of the X-ray sources in the FOV along the long direction. Together with the scan which determine the other direction, MAXI can scan almost all sky with a precision of better than 1 degree in the energy range of 0.5-30 keV. The CCD is electrically cooled to -60°C and the camera body is radiatively cooled to -20°C. The CCD chip itself and the radiators may suffer contamination problem. The continuous Ethernet down link will enable us to alert the astronomers in all over the world to the appearance of X-ray transients, novae, bursts, flares etc. We made a test counter and test chips in 1998. Those are being tested in RIKEN, NASDA and Osaka-university. In this paper the test results will be presented, as well as the general description of the MAXI mission

Detection of Pulsed X-ray Emission from The Fastest Millisecond Pulsar PSR B1937+21 with ASCA

We have detected pulsed X-ray emission from the fastest millisecond pulsar known, PSR B1937+21 (P=1.558 msec), with ASCA. The pulsar is detected as a point source above $\sim 1.7$ keV, with no indication of nebulosity. The source flux in the 2--10 keV band is found to be $f = (3.7\pm 0.6) \times 10^{-13}$ erg s$^{-1}$ cm$^{-2}$, which implies an isotropic luminosity of $L_{\rm x} = 4 \pi D^2 f \sim (5.7\pm 1.0) \times 10^{32} ~(D/3.6 {\rm kpc})^2$ erg s$^{-1}$, where D is the distance, and an X-ray efficiency of $\sim 5 \times 10^{-4}$ relative to the spin-down power of the pulsar. The pulsation is found at the period predicted by the radio ephemeris with a very narrow primary peak, the width of which is about 1/16 phase ($\sim 100 \mu$s), near the time resolution limit ($61 \mu$s) of the observation. The instantaneous flux in the primary peak (1/16 phase interval) is found to be ($4.0\pm 0.8) \times 10^{-12}$ erg s$^{-1}$ cm$^{-2}$. Although there is an indication for the secondary peak, we consider its statistical significance too low to claim a definite detection. The narrow pulse profile and the detection in the 2--10 keV band imply that the X-ray emission is caused by the magnetospheric particle acceleration. Comparison of X-ray and radio arrival times of pulses indicates, within the timing errors, that the X-ray pulse is coincident with the radio interpulse.Comment: 14 pages with 5 figures. Ap. J. in pres