144 research outputs found

    Psycho-historical rivalry of complexes in mentality of the Russian autocracy

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    Π‘Ρ‚Π°Ρ‚ΡŒΡ посвящСна ΠΎΡ€ΠΈΠ³ΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉ психоаналитичСской ΠΈΠ½Ρ‚Π΅Ρ€ΠΏΡ€Π΅Ρ‚Π°Ρ†ΠΈΠΈ становлСния российской государствСнности ΠΈ самодСрТавия, которая Ρ€Π°Π½Π΅Π΅ Π½Π΅ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡŒ Π² ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π΅ русского Π‘Ρ€Π΅Π΄Π½Π΅Π²Π΅ΠΊΠΎΠ²ΡŒΡ. Автор Π²ΠΏΠ΅Ρ€Π²Ρ‹Π΅ обращаСтся ΠΊ психоисторичСской ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ†ΠΈΠΈ гСнСзиса самодСрТавия: ΠΎΡ‚ формирования Московского Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ государства Π΄ΠΎ Π½Π°ΡˆΠΈΡ… Π΄Π½Π΅ΠΉ. Π­Ρ‚ΠΎΡ‚ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ опираСтся Π½Π° Π·Π°Ρ€ΡƒΠ±Π΅ΠΆΠ½Ρ‹Π΅ психоисторичСскиС исслСдования, Π½Π°Ρ‡Π°Ρ‚Ρ‹Π΅ Π›. Π”Π΅ Мозом, ΠΈ прСдставляСт Π½ΠΎΠ²ΡƒΡŽ ΠΈ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΡƒΡŽ ΡΡ‚Ρ€Π°Ρ‚Π΅Π³ΠΈΡŽ ΡΠΎΡ†ΠΈΠΎΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½Ρ‹Ρ… исслСдований. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π˜ΡΡ‚ΠΎΡ€ΠΈΡ страны прСдстаСт ΠΊΠ°ΠΊ хронология Π±Π΅ΡΡΠΎΠ·Π½Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΊΠΎΠ½ΠΊΡƒΡ€Π΅Π½Ρ†ΠΈΠΈ Π²Π΅Π΄ΡƒΡ‰ΠΈΡ… психичСских комплСксов российской ΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ. Π’ΠΎ-ΠΏΠ΅Ρ€Π²Ρ‹Ρ…, это «новгородский комплСкс нСполноцСнности московской аристократии» - ΠΈΡ‚ΠΎΠ³ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ противостояния ΠœΠΎΡΠΊΠ²Ρ‹ ΠΈ Новгорода, Π²ΠΏΠ»ΠΎΡ‚ΡŒ Π΄ΠΎ падСния Π²Π΅Ρ‡Π΅Π²ΠΎΠΉ рСспублики. Π’Ρ‚ΠΎΡ€Ρ‹ΠΌ сцСнариСм, Π²Ρ‹Ρ‚Π΅ΡΠ½ΡΡŽΡ‰ΠΈΠΌ «новгородский комплСкс», стал Β«Π·Π°ΠΏΠ°Π΄Π½Ρ‹ΠΉ комплСкс прСвосходства». Он воспроизводил колониальноС ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠΏΠ΅Ρ€ΠΈΠΈ ΠΊ своСй Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΈ. Π’Ρ€Π΅Ρ‚ΡŒΡ Π³Ρ€Π°Π½ΡŒ психоистории самодСрТавия связана с ΠΌΠ½ΠΎΠ³ΠΎΠ²Π΅ΠΊΠΎΠ²Ρ‹ΠΌ противостояниСм Ρ‚Π°Ρ‚Π°Ρ€ΠΎ-ΠΌΠΎΠ½Π³ΠΎΠ»ΡŒΡΠΊΠΎΠΌΡƒ Π½Π°ΡˆΠ΅ΡΡ‚Π²ΠΈΡŽ. Π‘ΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-политичСский ΡƒΠΊΠ»Π°Π΄ Ρ‚Π°Ρ‚Π°Ρ€ ΠΈ Π΄Ρ€ΡƒΠ³ΠΈΡ… стСпняков ΠΎΡ‡Π΅Π½ΡŒ сильно повлиял Π½Π° ΠΎΡ‚Π΅Ρ‡Π΅ΡΡ‚Π²Π΅Π½Π½ΡƒΡŽ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Ρƒ, язык ΠΈ ΠΏΠΎΠ»ΠΈΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΡŽ. Он проявился Π² Π°Π±ΡΠΎΠ»ΡŽΡ‚Π½ΠΎ Π±Π΅ΡΡΠΎΠ·Π½Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ комплСксС «завистничСского сравнСния», ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚ΠΎΠΌ Π’. Π’Π΅Π±Π»Π΅Π½ΠΎΠΌ. Московская аристократия Π±Π΅Π· Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ государства Π²Ρ‹Π½ΡƒΠΆΠ΄Π΅Π½Π° ΡΡƒΠ±Π»ΠΈΠΌΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ психоисторичСский ΠΊΠΎΠ½Ρ„Π»ΠΈΠΊΡ‚ Π² Ρ„ΠΎΡ€ΠΌΠ΅ Ρ€Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ, православно- Π°Π΄Π°ΠΏΡ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠ΄Π΅ΠΎΠ»ΠΎΠ³ΠΈΠΈ. Π’ Π½Π΅ΠΉ Π±Ρ‹Π»Π° сублимирована ΠΈ кочСвая модСль управлСния гСополитичСскими пространствами, ΠΏΡ€ΠΈΠ½ΡƒΠ΄ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ налоТСнная Π½Π° Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ Π·Π΅ΠΌΠ»Π΅Π΄Π΅Π»ΡŒΡ‡Π΅ΡΠΊΠΈΠΉ ΠΎΠ±Ρ‰ΠΈΠ½Π½ΠΎ- Ρ€ΠΎΠ΄ΠΎΠ²ΠΎΠΉ ΡƒΠΊΠ»Π°Π΄ Π”Ρ€Π΅Π²Π½Π΅ΠΉ ΠΈ Π‘Ρ€Π΅Π΄Π½Π΅Π²Π΅ΠΊΠΎΠ²ΠΎΠΉ Руси. ΠŸΠΎΡΠ»Π΅Π΄ΡƒΡŽΡ‰Π°Ρ история XVβˆ’XVI Π²Π². лишь ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π°Π΅Ρ‚ Ρ„Π°ΠΊΡ‚ сублимации комплСксов нСполноцСнности ΠΈ завистничСского сравнСния ΠΏΠΎ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡŽ ΠΊ Ρ‚Π°Ρ‚Π°Ρ€Π°ΠΌ.Horde on Moscow Rus predetermined the strategy of Β«enviousΒ» sublimation of the Β«steppe complexΒ» by Moscow elite, and final abandonment of sociocultural lessons and historical perspective of the Β«Novgorod complexΒ»

    РСконструкція Ρ– модСрнізація Ρ€Π΅Π»Π΅ΠΉΠ½ΠΎΠ³ΠΎ захисту Ρ– Π°Π²Ρ‚ΠΎΠΌΠ°Ρ‚ΠΈΠΊΠΈ ПБ Β«Π“Π΅Ρ€ΠΎΡ—Π² ΠšΠΎΡΠΌΠΎΡΡƒΒ» - 150/35/6 ΠΊΠ’

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    Π ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½Π° Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΈΡ‡Π½Π° схСма підстанції, Ρ‰ΠΎ Π²Ρ–Π΄Ρ€Ρ–Π·Π½ΡΡ”Ρ‚ΡŒΡΡ високою Π½Π°Π΄Ρ–ΠΉΠ½Ρ–ΡΡ‚ΡŽ СлСктропостачання. Новизна Ρ‚Π΅Ρ…Π½Ρ–Ρ‡Π½ΠΎΠ³ΠΎ Ρ€Ρ–ΡˆΠ΅Π½Π½Ρ полягає Π² використанні Π½ΠΎΠ²ΠΈΡ… Ρ‚Π° сучасних Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΎΠ°ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² Ρ‚Π° Ρ‚Π΅Ρ…Π½Ρ–Ρ‡Π½ΠΈΡ… засобів для підвищСння надійності Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ підстанції. Π‘Ρ„Π΅Ρ€Π° застосування Ρ€ΠΎΠ·Ρ€ΠΎΠ±ΠΊΠΈ – Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΈΡ‡Π½Ρ– підстанції Π½Π°ΠΏΡ€ΡƒΠ³ΠΎΡŽ 150/35/6 ΠΊΠ’. ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π½Π° Π·Π½Π°Ρ‡ΠΈΠΌΡ–ΡΡ‚ΡŒ ΠΊΠ²Π°Π»Ρ–Ρ„Ρ–ΠΊΠ°Ρ†Ρ–ΠΉΠ½ΠΎΡ— Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ – підвищСння надійності Ρ‚Π° Скономічності Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΈΡ‡Π½ΠΎΡ— підстанції

    Hydrogen production by chemical-looping reforming in a circulating fluidized bed reactor using Ni-based oxygen carriers

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    7 pages, 11 figures,.- Available online November 18, 2008.This work presents the experimental results obtained during auto-thermal chemical-looping reforming (CLR) in a 900 Wth circulating fluidized bed reactor under continuous operation using methane as fuel. Two oxygen carriers based on NiO and supported on Ξ³-Al2O3 and Ξ±-Al2O3 were used during more than 50 h of operation with each oxygen carrier. During operation the effect of different operating variables, like fuel reactor temperature, H2O/CH4 molar ratio and solid circulation rate, on CH4 conversion and gas product distribution was analyzed. It was found that in all operating conditions CH4 conversion was very high (>98%) and the most important variable affecting to the gas product distribution was the solid circulation rate, that is, NiO/CH4 molar ratio. Similar gas product distribution was obtained working with both oxygen carriers although at different NiO/CH4 molar ratios. The oxygen carrier of NiO on Ξ±-Al2O3 needed lower NiO/CH4 molar ratio to reach the same gas product composition than the oxygen carrier of NiO on Ξ³-Al2O3. Working at optimal operating conditions, 2.5 moles of H2 per mol of CH4 could be obtained in this process. During operation the oxygen carrier particles maintained their physical and chemical properties. These results suggest that these oxygen carriers could have a high durability, being suitable oxygen carriers for a CLR system. Β© 2008 Elsevier B.V. All rights reserved.This work was partially supported by the European Commission, under the 6th Framework Programme (CACHET Project, Contract no. 019972), and from the CCP2 (CO2 Capture Project), a partnership of BP, Chevron, Conoco-Phillips, Eni Technology, Norsk Hydro, Shell, Suncor, and Petrobras. M. Ortiz thanks DiputaciΓ³n General de Aragon for the F.P.I. fellowship.Peer Reviewe

    International Student Mobility: An Identity Development Task?

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    Based on the review of literature on internationalization of education and on identity formation pro cesses in young adults, this cross - sectional study aims to investigate to which extent self - perceived dimensions of identity are associated to the main moti vations to study abroad. The participants in this study were 429 international university students of different nationalities. Findings revealed that the motivation to study abroa d for personal growth is strongly associated to the commitment and in - depth e xploration identity processes, whereas the motivation to study abroad with the aim of changing life style and enlarging job opportunities is positively associated with reconsideration of commitment and in - depth exploration. Furthermore, identity achieved s tudents showed the highest motivation to s tudy abroad for personal growth, while the motivation to study abroad to positively change life - styles and work conditions is strongly associated with the positive facet of identity crisis, which is otherwise calle d searching - moratorium status. Based on these results, the present survey provides useful questions and hypothesis for future researc

    ΠžΡ†Π΅Π½ΠΊΠ° пСрсонала ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ Π½Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π΅ Вомского Ρ„ΠΈΠ»ΠΈΠ°Π»Π° ООО Β«Π“Π°Π·ΠΏΡ€ΠΎΠΌ ΠΌΠ΅ΠΆΡ€Π΅Π³ΠΈΠΎΠ½Π³Π°Π· Новосибирск»

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    ΠžΠ±ΡŠΠ΅ΠΊΡ‚ΠΎΠΌ исслСдования Π² Ρ€Π°Π±ΠΎΡ‚Π΅ являСтся: ΠΎΡ†Π΅Π½ΠΊΠ° пСрсонала, ΠΊΠ°ΠΊ инструмСнт управлСния пСрсоналом ООО Β«Π“Π°Π·ΠΏΡ€ΠΎΠΌ ΠΌΠ΅ΠΆΡ€Π΅Π³ΠΈΠΎΠ½Π³Π°Π· Новосибирск» Ρ„ΠΈΠ»ΠΈΠ°Π» Π² Π³. Вомск. ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹ – исслСдованиС систСмы ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° мСроприятий ΠΏΠΎ Π΅Π΅ ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡŽ для ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала ООО Β«Π“Π°Π·ΠΏΡ€ΠΎΠΌ ΠΌΠ΅ΠΆΡ€Π΅Π³ΠΈΠΎΠ½Π³Π°Π· Новосибирск». Π’ процСссС исслСдования ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡŒ: Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала Π² ООО Β«Π“Π°Π·ΠΏΡ€ΠΎΠΌ ΠΌΠ΅ΠΆΡ€Π΅Π³ΠΈΠΎΠ½Π³Π°Π· Новосибирск» Ρ„ΠΈΠ»ΠΈΠ°Π» Π² Π³. ВомскС. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ исслСдования: ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ‹ направлСния ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰Π΅ΠΉ систСмы ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ, основанной Π½Π° сочСтании KPI ΠΈ ΠΊΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ†ΠΈΠΉ Π² ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ, которая Π±ΡƒΠ΄Π΅Ρ‚ ΡΠ²Π»ΡΡ‚ΡŒΡΡ Π±ΠΎΠ»Π΅Π΅ эффСктивной, достовСрной ΠΈ Π³ΠΈΠ±ΠΊΠΎΠΉ, Ρ‡Π΅ΠΌ балльная систСма ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала ΠΈΠ»ΠΈ аттСстация пСрсонала с экономичСской ΠΈ финансовой Ρ‚ΠΎΡ‡ΠΊΠΈ зрСния. Π‘Ρ‚Π΅ΠΏΠ΅Π½ΡŒ внСдрСния: Π·Π°ΠΏΠ»Π°Π½ΠΈΡ€ΠΎΠ²Π°Π½ΠΎ внСсти дополнСния ΠΈ уточнСния Π² ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΡƒΡŽ систСму ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала ООО Β«Π“Π°Π·ΠΏΡ€ΠΎΠΌ ΠΌΠ΅ΠΆΡ€Π΅Π³ΠΈΠΎΠ½Π³Π°Π· Новосибирск» Ρ„ΠΈΠ»ΠΈΠ°Π» Π² Π³. Вомск. ЭкономичСская ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ/ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ Ρ€Π°Π±ΠΎΡ‚Ρ‹: Π’ Ρ†Π΅Π»ΠΎΠΌ Π²Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ систСмы ΠΎΡ†Π΅Π½ΠΊΠΈ пСрсонала основанной Π½Π° сочСтании KPI ΠΈ ΠΊΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ†ΠΈΠΉ ΠΏΠΎΠΌΠΎΠΆΠ΅Ρ‚ ΠΏΠΎΠ²Ρ‹ΡΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Π½Π° 25-30%, ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π·Π°Ρ‚Ρ€Π°Ρ‚Ρ‹ Π½Π° Ρ„ΠΎΠ½Π΄ вознаграТдСния сотрудников Π½Π° 15-20%, Π²Ρ‹ΡΡ‚Ρ€ΠΎΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΡƒΡŽ систСму стимулирования Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² ΠΏΡƒΡ‚Π΅ΠΌ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ систСмы прСмирования, ΡΠΈΡΡ‚Π΅ΠΌΠ°Ρ‚ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΠΊΠ°Π΄Ρ€ΠΎΠ²Ρ‹Π΅ процСссы.The object of research is the work: evaluation of personnel as human resources management tool of "Gazprom mezhregiongaz NovosibirskΒ» branch in Tomsk. Objective - research staff appraisal system and the development of measures to improve it for the evaluation of personnel of Β«Gazprom mezhregiongaz Novosibirsk". The study carried out: analysis of methods for evaluating staff of "Gazprom mezhregiongaz NovosibirskΒ» branch in Tomsk. As a result of research: proposed ways of improving the existing personnel evaluation system of the company, based on a combination of KPI and competency in the company, which will be more efficient, reliable and flexible than the point system of personnel evaluation and certification of personnel from an economic and financial point of view. Degree of implementation: planned to amend and clarify the existing personnel evaluation system of "Gazprom mezhregiongaz NovosibirskΒ» branch in Tomsk. Cost-effectiveness / value of the work: In general, the introduction of the staff appraisal system based on a combination of KPI and competencies will help improve business efficiency by 25-30%, to optimize the costs of employee compensation fund by 15-20%, to build an effective system of incentives for workers through the development of a system of bonuses , organize staffing processes

    ВлияниС ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π½ΠΎΠ³ΠΎ управлСния Π½Π° Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ Ρ€Π΅Π³ΠΈΠΎΠ½Π°

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    ΠœΠ°Π³ΠΈΡΡ‚Π΅Ρ€ΡΠΊΠ°Ρ диссСртация Π·Π½Π°ΠΊΠΎΠΌΠΈΡ‚ с исслСдованиСм Π² области Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ экономики. РассмотрСны Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Ρ‹, ΠΊΠ°ΠΊ ΠΎΠ±ΡŠΠ΅ΠΊΡ‚Ρ‹ управлСния Π² Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ экономикС. Π‘Π΄Π΅Π»Π°Π½Ρ‹ Π²Ρ‹Π²ΠΎΠ΄Ρ‹ Π½Π° основС Π°Π½Π°Π»ΠΈΠ·Π° осущСствлСния Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΎΠ² Π½Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π΅ Вомской области. ОсобоС Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡƒΠ΄Π΅Π»Π΅Π½ΠΎ взаимосвязи ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ Ρ€Π΅Π³ΠΈΠΎΠ½Π° ΠΈ Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΎΠ².The master's thesis introduces research in the field of regional economics. National projects are considered as objects of management in the regional economy. Conclusions are made based on the analysis of the implementation of national projects on the example of the Tomsk region. Particular attention is paid to the relationship between the development of the region and the implementation of regional projects

    The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro

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    Background Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistance to conventional therapeutic approaches in a wide range of malignancies. However, the role of survivin in chondrosarcoma has not been well studied. We examined the importance of survivin gene expression in chondrosarcoma and analysed its influences on proliferation, apoptosis and resistance to chemotherapy in vitro. Methods Resected chondrosarcoma specimens from which paraffin-embedded tissues could be extracted were available from 12 patients. In vitro experiments were performed in human chondrosarcoma cell lines SW1353 and Hs819.T. Immunohistochemistry, immunoblot, quantitative PCR, RNA interference, gene-overexpression and analyses of cell proliferation and apoptosis were performed. Results Expression of survivin protein was detected in all chondrosarcoma specimens analyzed, while undetectable in adult human cartilage. RNA interference targeting survivin resulted in a G2/M-arrest of the cell cycle and led to increased rates of apoptosis in chondrosarcoma cells in vitro. Overexpression of survivin resulted in pronounced resistance to doxorubicin treatment. Conclusions These findings indicate that survivin plays a role in the pathogenesis and pronounced chemoresistance of high grade chondrosarcoma. Survivin antagonizing therapeutic strategies may lead to new treatment options in unresectable and metastasized chondrosarcoma
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