The Hydro-Mechanical Properties of Fracture Intersections: Pressure-Dependant Permeability and Effective Stress Law

Fluid flow through the brittle crust is primarily controlled by the capability of fracture networks to provide pathways for fluid transport. The dominant permeability orientation within fractured rock masses has been consistently correlated with the development of fracture intersections; an observation also made at the meso-regional scale. Despite the importance attributed to fracture intersections in promoting fluid flow, the magnitude of their enhancement of fractured rock permeability has not yet been quantified. Here, we characterize the hydro-mechanical properties of intersections in samples of Seljadalur Basalt by generating two orthogonal, tensile fractures produced by two separate loadings using a Brazilian test apparatus, and measuring their permeability as a function of hydrostatic pressure. We observe that intersecting fractures are significantly more permeable and less compliant than two independent macro-fractures. We formulate a model for fracture intersection permeability as a function of pressure by adding the contributions of two independent fractures plus a tube-like cavity with an effective elastic compressibility determined by its geometry. Permeability measurements during cyclic loading allowed determination of the effective stress coefficient (α in pe = pc − αpp) for fracture and intersection permeability. We observe a trend of lower αintersection values with respect to αfracture, which suggests that the channels controlling fluid flow have a higher aspect ratio (are more tubular) for the intersections relative to independent fractures. Our results suggest that fracture intersections play a critical role in maintaining permeability at depth, which has significant implications for the quantification and upscaling of fracture permeability toward reservoir-scale simulations

Multi-porous extension of anisotropic poroelasticity : linkage with micromechanics

We thank the Editor, Prof. Ronaldo Borja, Prof. Mark Kachanov, and anonyomus reviewers for careful reading of themanuscript and their insightful comments. This research was supported financially by the NERC grant: “Quantifying theAnisotropy of Poroelasticity in Stressed Rock”, NE/N007826/1 and NE/T00780X/1.Peer reviewe

Sub-barrier fusion of the oxygen isotopes: A more complete picture

We have measured the sub-barrier fusion cross sections for 16,17,18O on 16O and we present the data and the experimental method in detail. The data were analyzed with a one-dimensional potential barrier inversion model, a two-dimensional incoming wave boundary condition model, and a two-dimensional Wentzel-Kramers-Brillouin model. We find that a multidimensional model is necessary to describe the enhanced fusion cross sections in oxygen and the two-dimensional incoming wave boundary condition model suggests that a complete description of the fusion, inelastic, and elastic cross sections is possible

Stress-Induced Anisotropic Poroelasticity in Westerly Granite

Funding Information: We thank T‐f. Wong and the associate editor for helpful reviews of this paper. We acknowledge financial support from the UK Natural Environment Research Council through Grants NE/L002485/1 to B.E., NE/S000852/1 to N.B. and NE/T007826/1 to D.H., T.M., and P.M., and the European Research Council under the European Union's Horizon 2020 research and innovation programme (project RockDEaF, Grant agreement 804685 to N.B.). Erratum In the originally published version of this article, the author contributions omitted coauthor Nicolas Brantut. Dr. Brantut has been added to Methodology, Software, Writing – original draft, Writing – review and editing, and Supervision. This version may be considered the authoritative version of record.Peer reviewedPublisher PD

Uniaxial compression of 3D printed samples with voids: laboratory measurements compared with predictions from Effective Medium Theory

3D printing technology offers the possibility of producing synthetic samples with accurately defined microstructures. As indicated by effective medium theory (EMT), the shapes, orientations, and sizes of voids significantly affect the overall elastic response of a solid body. By performing uniaxial compression tests on twenty types of 3D-printed samples containing voids of different geometries, we examine whether the measured effective elasticities are accurately predicted by EMT. To manufacture the sample, we selected printers that use different technologies; fused deposition modelling (FDM), and stereolithography (SLA). We show how printer settings (FDM case) or sample cure time (SLA case) affect the measured properties. We also examine the reproducibility of elasticity tests on identically designed samples. To obtain the range of theoretical predictions, we assume either uniform strain or uniform stress. Our study of over two hundred samples shows that measured effective elastic moduli can fit EMT predictions with an error of less than 5% using both FDM and SLA methods if certain printing specifications and sample design considerations are taken into account. Notably, we find that the pore volume fraction of the designed samples should be above 1% to induce a measurable softening effect, but below 5% to produce accurate EMT estimations that fit the measured elastic properties of the samples. Our results highlight both the strengths of EMT for predicting the effective properties of solids with low pore fraction volume microstructural configurations, and the limitations for high porosity microstructures.Comment: 43 pages, 19 figs, 9 table

Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission

Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission. In this study we use a novel infectious coculture system to examine these alternative modes of infection. Cell-to-cell transmission is relatively resistant to anti-HCV glycoprotein monoclonal anti- bodies and polyclonal immunoglobulin isolated from infected individuals, providing an effective strategy for escaping host humoral immune responses. Chimeric viruses expressing the structural proteins rep- resenting the seven major HCV genotypes demonstrate neutralizing antibody-resistant cell-to-cell trans- mission. HCV entry is a multistep process involving numerous receptors. In this study we demonstrate that, in contrast to earlier reports, CD81 and the tight-junction components claudin-1 and occludin are all essential for both cell-free and cell-to-cell viral transmission. However, scavenger receptor BI (SR-BI) has a more prominent role in cell-to-cell transmission of the virus, with SR-BI-specific antibodies and small-molecule inhibitors showing preferential inhibition of this infection route. These observations highlight the importance of targeting host cell receptors, in particular SR-BI, to control viral infection and spread in the liver

A Directional Crack Damage Memory Effect in Sandstone Under True Triaxial Loading

We thank J.G. Van Munster for providing access to the true triaxial apparatus at KSEPL and for technical support during the experimental program. This work was partly funded by NERC awards NE/N002938/1, NE/N003063/1, and by a NERC Doctoral Studentship, which we gratefully acknowledge. Supporting data are included in an SI file; any additional data may be obtained from JB (email: [email protected]).Peer reviewedPublisher PD

Factors Affecting Early Services for Children Who Are Hard of Hearing

To describe factors affecting early intervention (EI) for children who are hard of hearing, we analyzed (a) service setting(s) and the relationship of setting to families' frequency of participation, and (b) provider preparation, caseload composition, and experience in relation to comfort with skills that support spoken language for children who are deaf and hard of hearing (CDHH)