A study of rainfall in the Roman area in the years 1951--2000

The daily rainfall data collected in the second half of the last century at 31 climatic stations in Lazio, Italy, have been subjected to statistical analysis in order to describe the pluviometric regime of the whole area on a multi-decadal time scale. The stations, for their geographical distribution within the region under study, are apt to represent different climatic zones, namely, a coastal, a rural, a suburban and an urban zone. The data have been treated both as time series and as geographicalstatisticalv ariates with the double aim, first, to verify if in the area under study any changes in the yearly precipitation rate, frequency and its distribution over different classes of rain intensity, have occurred in the last 50 years; second, to evidence a possible correlation between the intensity of precipitation and any of some environmental variables such as altitude, distance from the coastline and distance from the urban site. As for the first issue, it can be concluded that the precipitations over the Roman area in the period 1951–2000 show no significant trend; in particular, no trend is visible in any of the single classes of rain intensity, both absolute and percentile-based, considering either their frequency or their percent contribution to the total. As for the second issue, significant correlations have been found in the spatial distribution of rainfall with any of the relevant environmental variables mentioned above. The results of the analysis also show that in the urban area a less amount of rain seem to fall than in the surroundings zones, a result that seems rather anomalous in consideration of the several known factors that favour the intensification of the rainfall in the city with respect to its surroundings. A detailed statistical characterization of all the single 31 stations over the whole period is also given via a separate study of the durations of droughts and of the statistics of rainy days, using best fits based on the Weibull probability distribution

A Double Fourier-Transform Imaging Algorithm for a 24 GHz FMCW Short-Range Radar

A frequency-modulated continuous-wave radar for short-range target imaging, assembling a transceiver, a PLL, an SP4T switch, and a serial patch antenna array, was realized. A new algorithm based on a double Fourier transform (2D-FT) was developed and compared with the delay and sum (DAS) and multiple signal classification (MUSIC) algorithms proposed in the literature for target detection. The three reconstruction algorithms were applied to simulated canonical cases evidencing radar resolutions close to the theoretical ones. The proposed 2D-FT algorithm exhibits an angle of view greater than 25° and is five times faster than DAS and 20 times faster than the MUSIC one. The realized radar shows a range resolution of 55 cm and an angular resolution of 14° and is able to correctly identify the positions of single and multiple targets in realistic scenarios, with errors lower than 20 cm

FK Comae Berenices, King of Spin: The COCOA-PUFS Project

COCOA-PUFS is an energy-diverse, time-domain study of the ultra-fast spinning, heavily spotted, yellow giant FK Com (HD117555; G4 III). This single star is thought to be a recent binary merger, and is exceptionally active by measure of its intense ultraviolet and X-ray emissions, and proclivity to flare. COCOA-PUFS was carried out with Hubble Space Telescope in the UV (120-300 nm), using mainly its high-performance Cosmic Origins Spectrograph, but also high-precision Space Telescope Imaging Spectrograph; Chandra X-ray Observatory in the soft X-rays (0.5-10 keV), utilizing its High-Energy Transmission Grating Spectrometer; together with supporting photometry and spectropolarimetry in the visible from the ground. This is an introductory report on the project. FK Com displayed variability on a wide range of time scales, over all wavelengths, during the week-long main campaign, including a large X-ray flare; "super-rotational broadening" of the far-ultraviolet "hot-lines" (e.g., Si IV 139 nm (T~80,000 K) together with chromospheric Mg II 280 nm and C II 133 nm (10,000-30,000 K); large Doppler swings suggestive of bright regions alternately on advancing and retreating limbs of the star; and substantial redshifts of the epoch-average emission profiles. These behaviors paint a picture of a highly extended, dynamic, hot (10 MK) coronal magnetosphere around the star, threaded by cooler structures perhaps analogous to solar prominences, and replenished continually by surface activity and flares. Suppression of angular momentum loss by the confining magnetosphere could temporarily postpone the inevitable stellar spindown, thereby lengthening this highly volatile stage of coronal evolution.Comment: to be published in ApJ

A detailed study of rainfall in the Roman area in the decade 1992–2001

A study of the rainfall regime in the Roman area over the decade 1992-2001 has been undertaken on using tipping pluviometers data, coming from 23 climatic stations located in Rome and in its surroundings. The time response of the instruments and the automatic acquisition system ensure a resolution of less than 1 minute, thus offering the possibility of an accurate evaluation of intense and extreme events. The mean yearly rainfall over the whole decade has been determined for each station, obtaining values between 682 and 870mm/year, with a geographical average of 771 and a standard deviation of 47. A study of the rainfall distribution within the 48 half-hours of the day has been carried out in order to ascertain whether preferred times for rain events exist. The analysis has evidenced that this is the case, with high rainfall rates mostly occurring in the late morning and low rates in the late night. Typical values of the maximum 30-min rainfall ever recorded at any given station oscillate between 25 and almost 60 mm. A separate analysis of rainy and dry days has been carried out on studying the statistics of the time delays between two successive tips of the pluviometer. This allowed a characterization of the intense rains as well as of the droughts: the resulting histograms show the existence of a bimodal distribution explained in terms of two kinds of rain events, intense summer showers and drizzles distributed over the rest of the year. As for the droughts, the longest durations appear to range from one to about seven months. On confining the analysis to the rainy days only, the rain intensity data for each station has been plotted and fitted with a Weibull distribution. The corresponding Weibull parameters, while gathering around common mean values, do not show any recognizable pattern when regressed, for instance, versus the altitude of the station or the distance from the coastline. Last, the likelihood that a day of the year, taken at random, be a rainy day or not has been computed for each station yielding probability values ranging from 0.18 to 0.22

Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma.

Intratumoral heterogeneity (ITH) is a prominent feature of kidney cancer. It is not known whether it has utility in finding associations between protein expression and clinical parameters. We used ITH that is detected by immunohistochemistry (IHC) to aid the association analysis between the loss of SWI/SNF components and clinical parameters.160 ccRCC tumors (40 per tumor stage) were used to generate tissue microarray (TMA). Four foci from different regions of each tumor were selected. IHC was performed against PBRM1, ARID1A, SETD2, SMARCA4, and SMARCA2. Statistical analyses were performed to correlate biomarker losses with patho-clinical parameters. Categorical variables were compared between groups using Fisher\u27s exact tests. Univariate and multivariable analyses were used to correlate biomarker changes and patient survivals. Multivariable analyses were performed by constructing decision trees using the classification and regression trees (CART) methodology. IHC detected widespread ITH in ccRCC tumors. The statistical analysis of the Truncal loss (root loss) found additional correlations between biomarker losses and tumor stages than the traditional Loss in tumor (total) . Losses of SMARCA4 or SMARCA2 significantly improved prognosis for overall survival (OS). Losses of PBRM1, ARID1A or SETD2 had the opposite effect. Thus Truncal Loss analysis revealed hidden links between protein losses and patient survival in ccRCC

Numerical and experimental comparison among a new hybrid FT-music technique and existing algorithms for through-the-wall radar imaging

A fast low-cost through-the-wall radar imaging (TWRI) system, based on a vector network analyzer (VNA), a couple of switches and an array of Vivaldi antennas, has been designed, realized, and tested. To solve the TWRI inversion problem, an original theoretical modeling for a class of TWRI techniques whose basic functions are the cross-range Fourier transform (FT) of the scattered field and its covariance operator has been proposed. Using these functions, four conventional algorithms, namely the delay and sum (DAS), the FT, the multiple signal classification (MUSIC), the hybrid DAS-MUSIC and a new algorithm, the hybrid FT-MUSIC, have been derived. All these techniques have been implemented and their accuracy and field of view have been tested on canonical scatterers. Then, the algorithms have been applied to measured data collected in different scenarios constituted by a metallic bar or a human subject in the absence and in the presence of a wall between the antenna and the considered targets. Using the proposed TWRI system, it has been possible to detect a subject located up to 5-m away from the radar antenna array through a tuff wall. The proposed FT-MUSIC algorithm has evidenced performances similar to those of the DAS-MUSIC but with significantly lower execution times. Finally, FT-MUSIC performances in terms of field of view and immunity to disturbances are better compared to those of the MUSIC algorithm

Low drug levels and thrombotic complications in high-risk atrial fibrillation patients treated with direct oral anticoagulants

Essentials Direct oral anticoagulants (DOACs) do not require laboratory monitoring currently. DOAC specific measurements were performed at trough in patients with atrial fibrillation. Patients who developed thromboembolic events showed lower DOAC plasma levels. This study supports the concept of measuring DOAC levels at steady state. Summary: Background Direct oral anticoagulants (DOACs) are administered at fixed doses without the need for dose adjustment according to laboratory testing. High interindividual variability in drug blood levels has been shown with all DOACs. To evaluate a possible relationship between DOAC C-trough anticoagulant levels and thromboembolic events, 565 consecutive naive patients with atrial fibrillation (AF) were enrolled in this study performed within the START Laboratory Registry. Methods DOAC-specific measurements (diluted thrombin time or anti-activated factor II calibrated for dabigatran; anti-activated FX calibrated for rivaroxaban or apixaban) at C-trough were performed locally at steady state within 15–25 days after the start of treatment. For each DOAC, the interval of C-trough levels, from the limit of quantification to the highest value, was subdivided into four equal classes, and results were attributed to these classes; the median values of results were also calculated. Thromboembolic complications occurring during 1 year of follow-up were recorded. Results Thromboembolic events (1.8%) occurred in 10 patients who had baseline C-trough levels in the lowest class of drug levels. The incidence of thromboembolic events among patients with DOAC C-trough levels in the lowest level class was 2.4%, and that in the remaining groups was 0%. The patients with thrombotic complications also had a higher mean CHA2DS2-VASc score than that of the total patient population: 5.3 (95% confidence interval [CI] 4.3–6.3 versus 3.0 (95% CI 2.9–3.1). Conclusion In this study cohort, thrombotic complications occurred only in DOAC-treated AF patients who had very low C-trough levels, with a relatively high CHA2DS2-VASc score. Larger studies are warranted to confirm these preliminary observations. © 2018 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis

X-ray Variability in the Young Massive Triple theta2 Ori A

Massive stars rarely show intrinsic X-ray variability. The only O-stars credited to be intrinsically variable are theta1 Ori C due to effects from magnetic confinement of its wind, and theta2 Ori A suspected of similar activity. Early Chandra observations have shown that the most massive star system in the Orion Trapezium Cluster, theta2 Ori A, shows rapid variability on time scales of hours. We determine X-ray fluxes and find that the star shows very strong variability over the last 5 years. We observed a second large X-ray outburst in November 2004 with the high resolution transmission grating spectrometer on-board Chandra. In the low state X-ray emissivities indicate temperatures well above 25 MK. In the high state we find an extended emissivity distribution with high emissivities in the range from 3 MK to over 100 MK. The outburst event in stellar terms is one of the most powerful ever observed and the most energetic one in the ONC with a lower total energy limit of 1.5x10^37 ergs. The line diagnostics show that under the assumption that the line emitting regions in the low states are as close as within 1 -- 2 stellar radii from the O-star's photosphere, whereas the hard states suggest a distance of 3 -- 5 stellar radii. The two outbursts are very close to the periastron passage of the stars. We argue that the high X-ray states are possibly the result of reconnection events from magnetic interactions of the primary and secondary stars of the spectroscopic binary. Effects from wind collisions seem unlikely for this system. The low state emissivity and R-ratios strengthen the predicament that the X-ray emission is enhanced by magnetic confinement of the primary wind. We also detect Fe fluorescence indicative of the existence of substantial amounts of neutral Fe in the vicinity of the X-ray emission.Comment: 11 pages, 8 figures, accepted for publication in The Astrophysical Main Journa