Student business incubator as a tool for development of youth entrepreneurship in Russia and Kyrgyzstan

В данной статье рассматриваются вопросы развития молодежного предпринимательства и возможной интеграции молодежи России и Кыргызстана в экономической сфере через обмен опытом по созданию бизнес-инкубаторов.This article discusses the development of youth entrepreneurship and the possible integration of the youth of Russia and Kyrgyzstan in the economic sector through the exchange of experiences on the establishment of business incubators

Phytocoenotic Distribution of Hulthemia persica (Michaut ex Juss.) Bornm. (Rosaceae) under Different Ecological Conditions in Uzbekistan

The paper presents some of the results of the 2020–2022 studies of 7 communities with the participation of a poorly studied forage and melliferous species, Hulthemia persica, in the Republic of Uzbekistan. The research goal is to identify the phytocenotic confinement of the poorly studied forage and melliferous species H. persica in various environmental conditions in the Republic of Uzbekistan. Phytocoenotic studies in 7 communities have shown that the population numbers of H. persica in the Tashkent Region (Parkentsay) are satisfactory. However, in recent years the strong impact of anthropogenic factors, primarily livestock grazing under natural growing conditions, has affected this species’ abundance, which has gradually disappeared. Large-scale exploration and prospecting, with the development of the oil and gas industry and other technogenic factors, has harmed the state of H. persica; therefore, populations lack young individuals and the cover provided by this species is relatively low. Therefore, it is crucial to strengthen protection measures, which the authors also recommend using for degraded pastures in the desert and foothill regions of the Republic of Uzbekistan. A detailed survey of natural populations and monitoring their condition should be carried out. In particular, H. persica is a promising plant adapted to various environmental conditions and can be used in degraded pastures in desert and foothill regions of the Republic of Uzbekistan

Metallic, magnetic and molecular nanocontacts

Scanning tunnelling microscopy and break-junction experiments realize metallic and molecular nanocontacts that act as ideal one-dimensional channels between macroscopic electrodes. Emergent nanoscale phenomena typical of these systems encompass structural, mechanical, electronic, transport, and magnetic properties. This Review focuses on the theoretical explanation of some of these properties obtained with the help of first-principles methods. By tracing parallel theoretical and experimental developments from the discovery of nanowire formation and conductance quantization in gold nanowires to recent observations of emergent magnetism and Kondo correlations, we exemplify the main concepts and ingredients needed to bring together ab initio calculations and physical observations. It can be anticipated that diode, sensor, spin-valve and spin-filter functionalities relevant for spintronics and molecular electronics applications will benefit from the physical understanding thus obtained

The Place of Portrait Generation in Easel Painting

This scientific article reveals the concept of the portrait genre, nature the importance of searching for character and a deep approach to it, and the ancient look at history. The importance of portraits of great people in the work of artists of our developed country and its analysis in the visual arts is reflected. At the same time, the role of portraiture in the development of the younger generation is reflected in the analysis through image

Valuable Orientations of Students in Modern Social and Economic Condition

This article examines the students’ value orientations and the problems of choosing life and professional paths in the new socio-economic conditions.В данной статье рассматриваются ценностные ориентации студентов и проблемы выбора жизненного и профессионального путей в новых социально-экономических условиях

Социокультурный портрет современных старшеклассников Киргизской Республики

The socio-cultural portrait of modern high school students of Kyrgyzstan has been identified, which will be used to develop a model of modern forms and methods of career guidance. Studies have shown that the core values of high school students in Kyrgyzstan are: family, health, education, successful career and close friends.Выявлен социокультурный портрет современных старшеклассников Киргизии, который будет положен в разработку модели современных форм и методов профориентационной деятельности. Как показали исследования, ценностное ядро старшеклассников Киргизии составляют семья, здоровье, образование, успешная карьера и близкие друзья.Исследование выполнено при поддержке Центра образования и развития Secom (Бишкек, Киргизская Республика)

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production

Prader-Willi syndrome (PWS) is a developmental disorder caused by loss of maternally imprinted genes on 15q11-q13, including melanoma antigen gene family member L2 (MAGEL2). The clinical phenotypes of PWS suggest impaired hypothalamic neuroendocrine function; however, the exact cellular defects are unknown. Here, we report deficits in secretory granule (SG) abundance and bioactive neuropeptide production upon loss of MAGEL2 in humans and mice. Unbiased proteomic analysis of Magel2pΔ/m+ mice revealed a reduction in components of SG in the hypothalamus that was confirmed in 2 PWS patient–derived neuronal cell models. Mechanistically, we show that proper endosomal trafficking by the MAGEL2-regulated WASH complex is required to prevent aberrant lysosomal degradation of SG proteins and reduction of mature SG abundance. Importantly, loss of MAGEL2 in mice, NGN2-induced neurons, and human patients led to reduced neuropeptide production. Thus, MAGEL2 plays an important role in hypothalamic neuroendocrine function, and cellular defects in this pathway may contribute to PWS disease etiology. Moreover, these findings suggest unanticipated approaches for therapeutic intervention