Solid state photodetectors and associated optical materials Final report

Solid state photoconductors and associated optical material

A Comprehensive Search for Gamma-Ray Lines in the First Year of Data from the INTEGRAL Spectrometer

We have carried out an extensive search for gamma-ray lines in the first year of public data from the Spectrometer (SPI) on the INTEGRAL mission. INTEGRAL has spent a large fraction of its observing time in the Galactic Plane with particular concentration in the Galactic Center (GC) region (~ 3 Msec in the first year). Hence the most sensitive search regions are in the Galactic Plane and Center. The phase space of the search spans the energy range 20-8000 keV and line widths from 0-1000 keV (FWHM). It includes both diffuse and point-like emission. We have searched for variable emission on time scales down to ~ 1000 sec. Diffuse emission has been searched for on a range of different spatial scales from ~ 20 deg (the approximate field-of-view of the spectrometer) up to the entire Galactic Plane. Our search procedures were verified by the recovery of the known gamma-ray lines at 511 keV and 1809 keV at the appropriate intensities and significances. We find no evidence for any previously unknown gamma-ray lines. The upper limits range from a few x 10^-5 cm^-2 s^-1 to a few x 10^-2 cm^-2 s^-1 depending on line width, energy and exposure; regions of strong instrumental background lines were excluded from the search. Comparison is made between our results and various prior predictions of astrophysical lines.Comment: Accepted for publication in Ap

Discovery of a New Nearby Star

We report the discovery of a nearby star with a very large proper motion of 5.06 +/- 0.03 arcsec/yr. The star is called SO025300.5+165258 and referred to herein as HPMS (high proper motion star). The discovery came as a result of a search of the SkyMorph database, a sensitive and persistent survey that is well suited for finding stars with high proper motions. There are currently only 7 known stars with proper motions > 5 arcsec/yr. We have determined a preliminary value for the parallax of 0.43 +/- 0.13 arcsec. If this value holds our new star ranks behind only the Alpha Centauri system (including Proxima Centauri) and Barnard's star in the list of our nearest stellar neighbors. The spectrum and measured tangential velocity indicate that HPMS is a main-sequence star with spectral type M6.5. However, if our distance measurement is correct, the HPMS is underluminous by 1.2 +/- 0.7 mag.Comment: 5 pages, 3 figures. Submitted to ApJ Letter

Detection of a fast, intense and unusual gamma ray transient

An unusual transient pulse of approximately 50 keV was detected by the gamma-ray burst sensor network using nine space probes and satellites. Its characteristics are unlike those of the known variety of gamma-ray bursts and therefore suggest that it was formed either by a completely different origin species or in a very different manner. It is identified with the LMC supernova remnant N49

Three precise gamma-ray burst source locations

The precise source regions of three moderately intense gamma ray bursts are derived. These events were observed with the first interplanetary burst sensor network. The optimum locations of the detectors, widely separated throughout the inner solar system, allowed for high accuracy, over-determined source fields of size 0.7 to 7.0 arc-min(2). All three locations are at fairly high galactic latitude in regions of low source confusion; none can be identified with a steady source object. Archived photographs were searched for optical transients that are able to be associated with these source fields; one such association was made

Early SPI/INTEGRAL contraints on the morphology of the 511 keV line emission in the 4th galactic quadrant

We provide first constraints on the morphology of the 511 keV line emission from the galactic centre region on basis of data taken with the spectrometer SPI on the INTEGRAL gamma-ray observatory. The data suggest an azimuthally symmetric galactic bulge component with FWHM of ~9 deg with a 2 sigma uncertainty range covering 6-18 deg. The 511 keV line flux in the bulge component amounts to (9.9+4.7-2.1) 10e-4 ph cm-2 s-1. No evidence for a galactic disk component has been found so far; upper 2 sigma flux limits in the range (1.4-3.4) 10e-3 ph cm-2 s-1 have been obtained that depend on the assumed disk morphology. These limits correspond to lower limits on the bulge-to-disk ratio of 0.3-0.6.Comment: 5 pages, 3 figures, accepted for publication in A&

The sky distribution of 511 keV positron annihilation line emission as measured with INTEGRAL/SPI

The imaging spectrometer SPI on board ESA's INTEGRAL observatory provides us with an unprecedented view of positron annihilation in our Galaxy. The first sky maps in the 511 keV annihilation line and in the positronium continuum from SPI showed a puzzling concentration of annihilation radiation in the Galactic bulge region. By now, more than twice as many INTEGRAL observations are available, offering new clues to the origin of Galactic positrons. We present the current status of our analyses of this augmented data set. We now detect significant emission from outside the Galactic bulge region. The 511 keV line is clearly detected from the Galactic disk; in addition, there is a tantalizing hint at possible halo-like emission. The available data do not yet permit to discern whether the emission around the bulge region originates from a halo-like component or from a disk component that is very extended in latitude.Comment: to be published in the proceedings of the 6th INTEGRAL Workshop "The Obscured Universe" (3-7 July 2006, Moscow

Constraints on the luminosity of the stellar remnant in SNR1987A

We obtain photometric constraints on the luminosity of the stellar remnant in SNR1987A using XMM-Newton and INTEGRAL data. The upper limit in the 2--10 keV band based on the XMM-Newton data is L<5*10^{34}erg/s. We note, however, that the optical depth of the envelope is still high in the XMM-Newton band, therefore, this upper limit does not constrain the true unabsorbed luminosity of the central source. The optical depth is expected to be small in the hard X-ray band of the IBIS telescope aboard the INTEGRAL observatory, therefore it provides an unobscured look at the stellar remnant. We did not detect statistically significant emission from SN1987A in the 20-60 keV band with the upper limit of L<1.1*10^{36}erg/s. We also obtained an upper limit on the mass of radioactive 44Ti M(44Ti)<10^{-3}Msun.Comment: 5 pages, 3 figures, accepted for publication in Astronomy Letter

SPI observations of positron annihilation radiation from the 4th galactic quadrant: sky distribution

During its first year in orbit the INTEGRAL observatory performed deep exposures of the Galactic Center region and scanning observations of the Galactic plane. We report on the status of our analysis of the positron annihilation radiation from the 4th Galactic quadrant with the spectrometer SPI, focusing on the sky distribution of the 511 keV line emission. The analysis methods are described; current constraints and limits on the Galactic bulge emission and the bulge-to-disk ratio are presented.Comment: 4 pages, 2 figures, accepted for publication in the proceedings of the 5th INTEGRAL worksho

Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity

DNA hypomethylation was previously implicated in cancer progression and metastasis. The purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene thought to exert anticancer effects, target genes with oncogenic function for de novo methylation and silencing, leading to inactivation of related signaling pathways. Following Illumina 450K, genome-wide DNA methylation analysis reveals that stilbenoids alter DNA methylation patterns in breast cancer cells. On average, 75% of differentially methylated genes have increased methylation, and these genes are enriched for oncogenic functions, including NOTCH signaling pathway. MAML2, a coactivator of NOTCH targets, is methylated at the enhancer region and transcriptionally silenced in response to stilbenoids, possibly explaining the downregulation of NOTCH target genes. The increased DNA methylation at MAML2 enhancer coincides with increased occupancy of repressive histone marks and decrease in activating marks. This condensed chromatin structure is associated with binding of DNMT3B and decreased occupancy of OCT1 transcription factor at MAML2 enhancer, suggesting a role of DNMT3B in increasing methylation of MAML2 after stilbenoid treatment. Our results deliver a novel insight into epigenetic regulation of oncogenic signals in cancer and provide support for epigenetic-targeting strategies as an effective anticancer approach