80 research outputs found
Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia
<p>Abstract</p> <p>Background</p> <p>One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to patients who do not have an optimal response to clozapine has been cited as the most common reason for simultaneously prescribing a second antipsychotic drug in combination treatment strategies. In a clinical area where the pressing need of providing therapeutic answers has progressively increased the occurrence of antipsychotic polypharmacy, despite the lack of robust evidence of its efficacy, we sought to implement a pre-planned protocol where two alternative therapeutic answers are systematically provided and evaluated within the context of a pragmatic, multicentre, independent randomised study.</p> <p>Methods/Design</p> <p>The principal clinical question to be answered by the present project is the relative efficacy and tolerability of combination treatment with clozapine plus aripiprazole compared with combination treatment with clozapine plus haloperidol in patients with an incomplete response to treatment with clozapine over an appropriate period of time. This project is a prospective, multicentre, randomized, parallel-group, superiority trial that follow patients over a period of 12 months. Withdrawal from allocated treatment within 3 months is the primary outcome.</p> <p>Discussion</p> <p>The implementation of the protocol presented here shows that it is possible to create a network of community psychiatric services that accept the idea of using their everyday clinical practice to produce randomised knowledge. The employed pragmatic attitude allowed to randomly allocate more than 100 individuals, which means that this study is the largest antipsychotic combination trial conducted so far in Western countries. We expect that the current project, by generating evidence on whether it is clinically useful to combine clozapine with aripiprazole rather than with haloperidol, provides physicians with a solid evidence base to be directly applied in the routine care of patients with schizophrenia.</p> <p>Trial Registration</p> <p><b>Clincaltrials.gov Identifier</b>: NCT00395915</p
Geodesia astronomica. Misura di deflessione della verticale con metodo astro-geodetico.
La classica geodesia astronomica riguarda la determinazione di latitudine, longitudine ed azimuth astronomici, mediante la misura di angoli, con strumenti ottici, collimando gli astri che osserviamo da punti della superficie terrestre, con la determinazione del tempo di passaggio
Misure di deflessione della verticale al campo base K2 durante la spedizione alpinistico-scientifica "K2 50 anni dopo" del luglio 2004
Algoritmi generalizzati di trasformazione tra coordinate geografiche, gaussiane, Cassini-Soldner
Nota tecnica sulle trasformazioni di coordinate plano-cartografiche dal sistema catastale Cassini-Soldner al sistema nazionale Gauss-Boaga
Studio e applicazione sperimentale di una metodologia geomatica per la valutazione dell’attendibilità degli elementi restituiti in una cartografia.
Analisi relativa ai dati GPS acquisiti durante una campagna di misure effettuata nell’isola di Salina nel giugno 2006. Utilizzo di differenti master temporanei per ottenere valori di coordinate precise di tracciati acquisiti in modalità cinematica
Applicazione delle metodologie geotopografiche satellitari per lo studio di modelli matematici del geoide in ambito locale
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