Sistematización de una experiencia. Quebrando esquemas y venciendo el miedo: Teatro espontáneo como una práctica de resistencia y legitimación social

Tesis (Magíster en Terapia Ocupacional)Esta tesis tiene como interés rescatar una experiencia concreta de Teatro Espontáneo (T.E.) con un grupo de personas con diagnósticos psiquiátricos severos que se encuentran en un contexto de rehabilitación en una institución de salud. Se propone mostrar la realidad de este grupo y su forma de expresarla, reflexionarla y abrir caminos de transformación social. Se hace énfasis en un enfoque crítico con un interés ético de transformación. Para estos propósitos se llevó a cabo una investigación cualitativa de tipo descriptiva, sostenida en una sistematización de la experiencia, esta experiencia tiene una duración de un año completo (2014) y da cuenta de un proceso vivido en un taller de T.E. en el cual se transita con el grupo por diversos momentos dando cuenta de un camino de desarrollo y conciencia grupal. Al realizar el análisis de la información se concluye que el T.E. facilita la expresión grupal, desde lo corporal, lo reflexivo y lo social. El grupo logra construir un espacio de visibilización social, quitándose el rotulo de “paciente psiquiátrico”. En este contexto el T.E. logra ser una herramienta de liberación de la locura reprimida por la psiquiatría y por los contextos políticos históricos actuales. También se identifica que las vivencias relatadas por el grupo, están determinadas transversalmente por la experiencia del estigma, de esta forma, el T.E. se transforma en una herramienta de resistencia permitiéndole al grupo salir al encuentro del medio externo mostrando su identidad. La investigación permite visibilizar a la Terapia Ocupacional desde un sentido ético y político, ya que abre caminos a la expresión de lo reprimido social y científicamente, también enriquecer su relación con otros saberes como el Teatro Espontaneo, para lograr ser un aporte concreto en procesos de conciencia y transformación grupal

Psoriatic Animal Models Developed for the Study of the Disease

Psoriasis is a skin disease mainly developed in humans, although it is also seen in monkeys and dogs. Animal models with psoriasis-like lesions have been a key factor for its understanding. Xenotransplants of human psoriatic skin in immunodeficient mice were the first approach for the association of immunologic problems with the development of psoriasis and have been also useful for the evaluation on new therapeutic agents. Imiquimod-induced murine psoriasis is nowadays one of the most used animal models to study this disease, perhaps because healthy wild-type mice are used, which means that it is an affordable model, easy to generate, and, more importantly, resembles the inflammatory, angiogenic and hyperproliferative characteristics of human psoriasis. Several transgenic (over-expressing VEGF, Tie2, TGFβ, STAT3, IL-36, PPARβ/γ) and knockout (lacking IκBα, JunB, IFNR-2, IL-36RA, CD18, IKK2) mice have been useful for the association of specific molecules for the development of psoriasis. Other approach has been the use of both transgenic/knockout mice and imiquimod treatment, where the importance of βTrCP, IκBζ, IL-35 and Tnip1 for the development of psoriasis was found. In this chapter, some of these animal models are discussed

Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya

Background: Transmitted drug resistance (TDR) is increasing in some areas of Africa. Detection of TDR may predict virologic failure of first-line non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based antiretroviral therapy (ART). We evaluated the utility of a relatively inexpensive oligonucleotide ligation assay (OLA) to detect clinically relevant TDR at time of ART initiation. Methods: Pre-ART plasmas from ART-naive Kenyans initiating an NNRTI-based fixed-dose combination ART in a randomized adherence trial conducted in 2006 were retrospectively analyzed by OLA for mutations conferring resistance to NNRTI (K103N, Y181C, and G190A) and lamivudine (M184V). Post-ART plasmas were analyzed for virologic failure (≥1,000 copies/mL) at 6 month intervals over 18-month follow-up. Pre-ART plasmas of those with virologic failure were evaluated for drug resistance by consensus and 454-pyrosequencing. Results: Among 386 participants, TDR was detected by OLA in 3.89% [95% Confidence Interval (CI), 2.19-6.33], and was associated with a 10-fold higher rate of virologic failure [Hazard Ratio (HR), 10.39; 95% CI, 3.23-32.41; p Conclusions: Detection of TDR by a point mutation assay may prevent use of sub-optimal ART

Biological nitrification inhibition and forage productivity of Megathyrsus maximus in Colombian dry tropics

Agronomic, nutritional, and environmental aspects are integrated to promote sustainable tropical grassland production. Biological nitrification inhibition (BNI) is a plant-based strategy to improve nitrogen use efficiency by grasses in which they suppress the pace of soil nitrification via exudation of inhibitory compounds. To evaluate the effect of BNI on the productive performance of Megathyrsus maximus under field conditions, we evaluated a collection of 27 germplasm accessions and commercial cultivars of the forage grass in the dry tropics of Colombia. We measured plant yield dry matter, nutrition quality parameters, and nitrification rates of soil at 22 months after pasture establishment. Our results highlighted germplasm accessions of superior agronomic performance (for dry matter production and nutrition quality) and high capacity to decrease nitrification. Although no relation was observed between agronomic aspects, nutritional aspects, and nitrification rates, we conclude that there is no agronomic or nutritional penalty on environmentally friendly grasses, and BNI could be adopted as a target trait in plant breeding programs toward the development of eco-efficient forages and contribute to the sustainable intensification of livestock systems

Caracterización sensorial, contenido de azúcares y betacarotenos de nuevos cultivares de zanahoria

El objetivo del trabajo fue caracterizar sensorialmente y evaluar la calidad nutricional en cuanto al contenido de azucares y betacarotenos de nuevos cultivares de zanahoria

Design, synthesis and biological evaluation of new embelin derivatives as CK2 Inhibitors

A new series of furan embelin derivatives was synthesized and characterized as ATPcompetitive CK2 inhibitors. The new compounds were efficiently synthesized using a multicomponent approach from embelin (1), aldehydes and isonitriles through a Knoevenagel condensation/ Michael addition/ heterocyclization. Several compounds with inhibitory activities in the low micromolar or even submicromolar were identified. The most active derivative was compound 4l (2-(tert-butylamino)-3-(furan-3-yl)-5- hydroxy-6-undecylbenzofuran-4,7-dione) with an IC50 value of 0.63 μM. It turned out to be an ATP competitive CK2 inhibitor with a Ki value determined to be 0.48 μM. Docking studies allowed the identification of key ligand-CK2 interactions, which could help to further optimize this family of compounds as CK2 inhibitor

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum