Medicinal plants with gastroprotective potential

Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.

Pharmacological evaluation of Vernonia elaeagnifolia (Asteraceae) leaves in hyperlipidemic albino rabbits

Purpose: To evaluate the antihyperlipidemic efficacy and phytochemical constituents of Vernonia elaeagnifolia aqueous leaf extract.Method: Qualitative phytochemical analysis of V. elaeagnifolia leaves was performed. Thirty healthy albino rabbits were divided into six groups (n = 6). Cholesterol powder (0.5 g/kg) in 10 mL coconut oil (vehicle) was given orally to induce hyperlipidemia. The aqueous leaf extract of Vernonia elaeagnifolia was administered at 250 mg/kg and 500 mg/kg per oral. Lipid profile, hepatic enzymes and oxidative stress markers were evaluated.Results: Phytochemical screening indicated the presence of tannins, proteins, flavonoids, phenols, alkaloids and saponins. Oral administration of cholesterol powder significantly (p < 0.05) raised the level of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and triglyceride (TG) along with significant (p < 0.05) decrease in serum concentration of high-density lipoprotein cholesterol (HDLc). Concentration of serum TC, LDL-c, TG and liver enzymes was significantly reduced in V. elaeagnifolia-treated groups. The levels of oxidative stress markers were restored to normal when the animals were treated with V. elaeagnifolia leaf extract; increased levels of antioxidant enzymes were observed.Conclusion: The aqueous leaf extract of V. elaeagnifolia possesses antihyperlipidemic and antioxidant potentials that are dose-dependent. However, further studies are required to develop the plant for therapeutic applications.Keywords: Hyperlipidemia, Oxidative stress markers, Cholesterol, Vernonia elaeagnifoli

Potencial de protección de las semillas Trachyspermum ammi en la nefrotoxicidad inducida por la gentamicina en modelo de conejo

La nefrotoxicidad es uno de los efectos secundarios más importantes limitaciones terapéuticas de los antibióticos aminoglucósidos, especialmente gentamicina. La nefrotoxicidad inducida por gentamicina implica generación de radicales libres, la reducción en el mecanismo de defensa antioxidante y la disfunción renal. Una serie de extractos de hierbas crudas tienen potencial para mejorar la nefrotoxicidad inducida por gentamicina debido a la presencia de varios compuestos antioxidantes. Por lo tanto, el objetivo del presente estudio fue evaluar la actividad protectora del extracto acuoso semillas de T. ammi contra la nefrotoxicidad inducida por gentamicina en conejos albinos. Los resultados mostraron que la gentamicina causó graves alteraciones en los parámetros bioquímicos séricos y los marcadores de riñón, junto con alteraciones severas en los tejidos renales. Sin embargo, el extracto de T. ammi, cuando se administra junto con la gentamicina, invierte la gravedad de la nefrotoxicidad inducida por gentamicina por la normalización de los indicadores de la función renal, por ejemplo, urea sérica, creatinina, nitrógeno ureico en sangre, albúmina y los parámetros de electrolitos séricos que indican el potencial nefroprotector de T. ammi. Del mismo modo, el extracto tiene la capacidad para aumentar la maquinaria enzimática antioxidante endógena mediante un aumento de la actividad de la enzima antioxidante catalasa y reduciendo el estado total de oxidante. El potencial nefroprotector fue confirmado por el examen histopatológico. El potencial nefroprotector podría ser debido a la presencia de compuestos polifenólicos antioxidantes en el extracto acuoso de semillas de T. Ammi

High Dose of Recombinant Bovine Somatotropin Do Alter Serum Biochemical and Hormonal Profiles of Nili Ravi Buffaloes

A research study was conducted to investigate the effect of high dose of recombinant bovine somatotropin (rbST) on the serum biochemical, liver enzymes and hormones of Nili Ravi buffaloes. Clinically healthy lactating buffaloes (n=16) were selected and divided into two equal groups. One served as experimental group (n=8) and the other as a control (n=8). Dose of 500 mg rbST/16 days/animals was injected subcutaneously to the experimental group subcutaneously, twice during the experimental period of 32 days after an interval of 16 days. Serum biochemical parameters (glucose, cholesterol, total proteins, urea and globulin), serum hormones (T3, T4 and cortisol) and liver enzymes (AST and ALT) were estimated. Glucose was significantly high while total proteins, globulin and urea were significantly low in the treated group. Significantly high ALT and low T4 level were recorded in the bST treated group. It was concluded from this study that the studied parameters did alter in buffaloes with 500 mg rbST injection

Effect of black pepper, turmeric and ajwa date on the endocrine pancreas of the experimentally induced diabetes in wister albino rats: A histological and immunohistochemical study

Background: Diabetes is now a global problem and millions of people are suffering all over the world. Reports exist for the allopathic use of turmeric, black pepper, and date palm as an antidiabetic and antioxidant agent. Aim: The current study was designed to assess the antihyperglycemic, antioxidants and antihyperlipidemic consequences of black pepper (BP), turmeric (T), ajwa pulp (AP), and ajwa seeds (AS) in alloxan-induced diabetic rats. Methodology: Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg b.w) in rats. They were randomly divided into 11 groups of 18 male and 18 female rats each. Group-1 normal control, group-2 diabetic control, group-3 was administered with glibenclamide (10 mg/kg), group-4 was administered with aqueous extract of BP (50 mg/kg), group-5, 6, 7 were administered with T, AP and AS (500 mg/kg) and group-8, 9, 10, 11 were administered with different combinations of aqueous extract (500 mg/kg) once in a day for eight weeks. The antihyperglycemic potential was determined through biochemical and histological investigations of the experimental animals at the end of the experiment. Results: The results of the study revealed that treatments improved glucose (229.53 mg/dL), Ghb (7.68%), insulin (13.63 U/L), Tg (95.92 mg/dL), Tc (152.86 mg/dL), HDL (23.22 mg/dL), LDL (110.30 mg/dL), TAC (1.89 mmol/L) and TOS (20.05 μmol/L) in comparison to diabetic control rats after 8 weeks of study period. Histological and immunohistochemical investigation of tissues exhibited severe changes in the pancreas of diabetic rats and treatments modulate these changes; this improvement in cells may explain the antidiabetic effects. Conclusion: It is concluded that aqueous extract of BP+AS; and BP+T+AP+AS could be promising nutraceutical therapy for diabetes management and its associated complications

Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats

The present study assessed in vivo endocrine disrupting effect of orally administered lambda-cyhalothrin (LCT) on metabolic hormones and correlated it with hematological instabilities. Adult female albino rats were divided in three equal groups; one kept as control and other two treated with 20 and 40 mg/kg BW LCT, respectively by oral gavage for 14 days. At the end of trial, blood was collected for hormonal and hematological analysis. The results showed that LCT led to reduction in serum triiodothyronine (T3) and thyroxin (T4) level (P<0.001) without modifying serum thyroid stimulating hormone (TSH) level in a dose related manner. Lambda-cyhalothrin also caused a significant (P<0.05) reduction in hemoglobin (Hb) concentration, red blood cell (RBC) count, total leukocyte count (TLC), platelets count, pack cell volume (PCV) and lymphocyte count. No significant variation was observed in erythrocytic indices. In sum, orally administered LCT caused reduction in feed intake and body weight along with disruption of hemato-biochemical parameters

Novel techniques for microbiological safety in meat and fish industries

The consumer tendency towards convenient, minimally processed meat items has placed extreme pressure on processors to certify the safety of meat or meat products without compromising the quality of product and to meet consumer’s demand. This has prompted difficulties in creating and carrying out novel processing advancements, as the utilization of more up-to-date innovations may influence customer decisions and assessments of meat and meat products. Novel advances received by the fish and meat industries for controlling food-borne microbes of huge potential general wellbeing concern, gaps in the advancements, and the requirement for improving technologies that have been demonstrated to be effective in research settings or at the pilot scale shall be discussed. Novel preparing advancements in the meat industries warrant microbiological approval before being named as industrially suitable alternatives and authorizing infra-structural changes. This miniature review presents the novel techniques for the microbiological safety of meat products, including both thermal and non-thermal methods. These technologies are being successfully implemented and rationalized in subsisting processing surroundings.Ministry of Science and Education of the Russian Federation | Ref. 075-15-2020-77

The prophylactic potential of Zingiber officinale flowers and leaves extract to mitigate hyperglycemia in Sprague Dawley rats

International audiencePurpose Innovative health-promoting approaches of the era have verified phytoceutics as one of the prime therapeutic tools to alleviate numerous health-related ailments. The purpose of this paper is to probe the nutraceutic potential of ginger flowers and leaves against hyperglycemia. Design/methodology/approach The aqueous extracts of ginger flowers and leaves were observed on Sprague Dawley rats for 8 weeks. Two parallel studies were carried out based on dietary regimes: control and hyperglycemic diets. At the end of the experimental modus, the overnight fed rats were killed to determine the concentration of glucose and insulin in serum. The insulin resistance and insulin secretions were also calculated by formulae by considering fasting glucose and fasting insulin concentrations. Furthermore, the feed and drink intakes, body weight gain and hematological analysis were also carried out. Findings In streptozotocin-induced hyperglycemic rats, the ginger flowers extract depicted 5.62% reduction; however, ginger leaves extract reduced the glucose concentration up to 7.11% ( p = 0.001). Similarly, ginger flowers extract uplifted the insulin concentration up to 3.07%, while, by ginger leaves extract, the insulin value increased to 4.11% ( p = 0.002). For the insulin resistance, the ginger flower showed 5.32% decrease; however, the insulin resistance was reduced to 6.48% by ginger leaves ( p = 0.014). Moreover, the insulin secretion increased to 18.9% by flower extract and 21.8% by ginger leave extract ( p = 0.001). The feed intake and body weight gain increased momentously by the addition of ginger flowers and leaves; however, the drink intake and hematological analysis remained non-significant by the addition of ginger parts. Originality/value Conclusively, it was revealed that leaves have more hypoglycemic potential as compared to flowers

Food-induced anaphylaxis: causes, risk factors and clinical management

Globally, food processing patterns are becoming more sophisticated and modernized for meeting abrupt increase in demand of allegen free food. The stance of availability of allergens free food is a rather hectic task to implement and consumers most probably become prone to them. Anaphylaxis is a serious health-related syndrome due to the adverse response of immune system. It aggravates by the consumption of foods that contain allergens by ultimately activating basophils and mast cells. There are more or less ten prominent foods that trigger anaphylaxis after the ingestion. Hence, avoiding allergen-containing food can limit the proliferation of anaphylaxis. In this article, the occurrence of allergic reactions with respect to sex disparities, most probable food allergens, diagnostic approaches and its management are discussed

Comparative study of physicochemical and hedonic response of ginger rhizome and leaves enriched patties

International audienceThe present investigation was an attempt to compare the phytoceutic potential of ginger rhizome and ginger leaves of the Suravi variety. For this purpose, both rhizome and leaves were dried and used for the preparation of patties. After that, patties were assessed for colour tonality, texture, total phenolic content and hedonic response such as colour, taste, flavour, texture and overall acceptability. The results depicted that L* and b* values changed significantly during the storage interval; however, b* value was also affected by treatments whilst L* and a* values did not impart any momentous effect. For texture, the highest value was observed for patties with ginger rhizome powder (0.067 ± 0.0032 N) followed by patties with ginger leaf powder (0.060 ± 0.0029 N) and then control patties (0.057 ± 0.0026 N). For total phenolic content (TPC), maximum phenolic contents were observed as 84.80 ± 3.31 mg GAE 100 g–1 in treatment T2 followed by 75.68 ± 2.95 mg GAE 100 g–1 in T1 and 61.70 ± 2.41 mg GAE 100 g–1 in T0. For hedonic response, all the parameters changed significantly during the storage interval; however, flavour, taste and overall acceptability changed momentously with treatments. The findings of the current investigation demonstrated that ginger leaves have a higher antioxidant potential as compared to the ginger rhizome and control patties, and they should be incorporated into food products