Neuroprotective effect of magnesium on lipid peroxidation and axonal function after experimental spinal cord injury

Study design: An experimental study examining the neuroprotective effect of magnesium on axonal function and lipid peroxidation in a rat model of acute traumatic spinal cord injury. Objective: To determine the effectiveness of postinjury treatment with magnesium on evoked potentials and lipid peroxidation after spinal cord injury (SCI). Setting: Pamukkale University, Denizli, Turkey. Methods: Spinal cord injury occurred in 30 rats with an aneurysm clip at T9 and the rats were randomly assigned to undergo subcutaneous administration of one of the following at 1 h after injury: (1) Physiological saline (n = 10); (2) MgSO4, 300 mg/kg (n = 10) and (3) MgSO4, 600 mg/kg (n = 10). Spinal somatosensory evoked potentials (SSEPs) were recorded before injury, 30 min after injury and 3 h after injections. Rats were killed 24 h after the injury, and malondialdehyde (MDA) levels were measured. Results: Following SCI, there were significant decreases in the amplitudes of P1 and N1 (P 0.001) and only high-dose magnesium improved the SSEPs (P < 0.01). On the other hand, there was significant difference in lipid peroxide content between high-dose magnesium treated group and both of saline treated and low-dose magnesium treated groups (P < 0.01). Conclusion: These results suggest that magnesium has a dose-dependent neuroprotective effect on SSEPs and lipid peroxidation after experimental spinal cord injury

EFFECT OF BROWN ALGAE (Sargassum Sp) GEL ON ALKALINE PHOSPHATASE LEVELS IN PERIODONTITIS RATS INDUCED BY SILK LIGATION MODEL

Introduction: Periodontitis is a chronic inflammatory disease caused by colonies of dysbiotic bacteria that form biofilms and cause destruction of the periodontal tissues. This damage can be induced by silk ligation on Sprague Dawley teeth and results in an increase in Alkaline Phosphate levels in the gingival sulcus. The purpose of this study was to determine the effect of brown algae extract gel (Sargassum sp) on reducing alkaline phosphatase levels in gingival sulcus fluid in Sprague Dawley periodontitis induced by silk ligation Material and Methods: This research is True Experimental with the Pre test - Post test Control Group Design. The research sample consisted of 36 male Wistar rats which were ligated with silk to periodontitis. Rats were divided into two groups (n=18), the control group was treated with Tie-es metronidazole gel plus and brown algae extract (Sargassum sp) gel treatment with a concentration of 75%. Sampling of gingival sulcus fluid (CSG) on days 0 and 5, ALP levels were measured using a UV/V is spectrophotometer with an absorbance of 450 nm. Results and Discussions: This study showed a decrease in ALP levels after being treated with metronidazole and 75% brown algae extract gel, the normal amount of ALP levels in the reference was 53-57 U/L and increased when inflammation occurred to 8283 U / L then a significant difference was obtained. The average reduction in ALP levels from pre test to post test for each group was 39-41  /L, and there was a significant relationship between giving brown algae extract and a decrease in ALP levels (p <0.05). Conclusion: Brown algae gel extract (Sargassum sp) concentration of 75% has a lowering effect on alkaline phosphatase levels of gingival sulcus fluid in periodontitis induced by silk ligatio

Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia

Extramedullary hematopoiesis associated with thalassemia causing spinal cord compression is an extremely rare event in the course of the disease. Documentation with an imaging technique, such as MRI, is mandatory. A patient with thalassemia intermedia, who developed paraparesis in spite of transfusion, underwent surgical decompression. Rapid neurological improvement was observed postoperatively and this neurological condition was protected with adequate hemoglobin level. Management of these patients remains controversial. Various modes of therapy such as surgical decompression, radiotherapy, and transfusion are discussed and the related literature is reviewed