Fertility of crustal rocks during anatexis

After many years of systematic experimental investigations, it is now possible to quantify the conditions for optimum fertility to melt production of most common crustal rock types as functions of temperature and to about 30 kbar pressure. Quartzo-feldspathic melting produces steady increases in melt proportion with increasing temperature. The exact melt fraction depends on the mineral mode relative to quartz-feldspar eutectics and the temperatures of mica dehydration melting reactions. Mica melting consumes SiO2 from residual quartz during the formation of refractory Al2SiO5, orthopyroxene, garnet or cordierite. A simple graphical interpretation of experimental results allows a deduction of the proportions of mica and feldspar leading to optimum fertility. In effect, the mica dehydration melting reactions, at specific pressure and are superimposed on quartz-feldspar melting relations projected onto Ab-An-Or. Fertility to melt production varies with the mica to feldspar ratio and pressure. Pelites are more fertile than psammites at low pressures (e.g. 5 kbar), especially if they contain An40 to An50 plagioclase. At higher pressure (e.g. 10-20 kbar) and for rocks containing albitic plagioclase, psammites are more fertile than pelites. For a typical pelite (e.g. with An25 at 20 kbar), the cotectic with muscovite lies at higher (≍·) and XAb (≍0·42) than with biotite :≍0·35; XAb(≍·), thus dehydration melting of muscovite requires 10% more plagioclase for fertility than does biotite. The first melts from dehydration melting of muscovite (with Plg + Qtz) are more sodic and form at lower temperatures than the first melts from Bio + Plg + Qtz. With increasing pressure, to at least 30 kbar, granite minimum and mica dehydration melts become more sodic. This indicates that of such melts is greater than 0·

Subsolidus and Partial Melting Reactions in the Quartz-excess CaO+MgO+Al2O3+SiO2+H2O System under Water-excess and Water-deficient Conditions to 10 kb: Some Implications for the Origin of Peraluminous Melts from Mafic Rocks

Experimental results up to 10 kb pressure are presented on the stability of amphibole in the quartz-excess CaO+MgO+Al2O3 (CMASH) system under H2O)-excess and H2O deficient conditions. Amphibole is stable above the solidus under H2O-excess conditions whereas under H2O-deficient conditions dehydration melting of amphibole-bearing assemblages defines the solidus. The successive appearance of amphibole, talc, and zoisite with increasing pressure considerably modifies the plagioclase-pyroxene-garnet-kyanite reactions documented experimentally in the CaO+MgO+Al2O3+SiO2 system for gabbro-granulite-eclogite transitions. Although both clino pyroxene and cordierite (with anorthite+orthopyroxene+quartz) may melt eutectically at one atmosphere to form diopside-normative and corundum-normative melts respectively, at higher pressures under H2O-excess conditions the peritectic melting of mafic rock compositions produces corundum-normative liquids together with either clinopyroxene or amphibole. Dehydration melting produces melts which are not corundum-normative. These data are used to discuss the origins and evolution of contrasting basalt-andesite-dacite-rhyolite volcanic suites and granitic plutons, many of whose silicic variants are corundum-normative in character, such as the Toba luff ignimbrites, Indonesia (Beddoc-Stephens et al., 1983) and I-type granite minimum melts (White & Chappell, 1977). In contrast, it is proposed that for the Cascades basalt-andesite-dacite-rhyolite suite the ortho pyroxene-plagioclase-quartz thermal divide was maintained up to rhyolite compositions, thereby prohibiting the derivation of corundum-normative rocks from diopside-normative parent magmas. The deduced reaction relations between pyroxenes, amphibole, plagioclase, quartz, and liquid are used to explain the absence or extreme scarcity of hydrous phases in some hydrous magmas. These phase relations can also explain the development of later plagioclase overgrowths on resorbed plagioclase cores in granitic intrusives, and the general absence of resorption and overgrowths in chemically equivalent extrusive rocks. A theoretical analysis of the partial melting of forsterite-bearing assemblages in the CaO+MgO+Al2O3+SiO2+H2O system shows that under H2O-excess conditions partial melting may generate corundum-normative (but low SiO2) melts from a peridotite source at shallow depth

Pressure—Temperature—Time Paths of Regional Metamorphism II. Their Inference and Interpretation using Mineral Assemblages in Metamorphic Rocks

A companion paper (England & Thompson, 1984a) investigates the pressure-temperature-time (PTt) paths followed by rocks undergoing burial metamorphism in continental thickening events. This paper discusses problems involved in inferring such paths from the petrological data available in metamorphic rocks and—once such paths are determined—how they may be interpreted in terms of the thermal budgets of metamorphism. Each of the principal facies series (glaucophane-jadeite, andalusite- sillimanite and kyanite-sillimanite) may be encountered by rocks involved in the thickening and erosion of continental crust in a regime of average continental heat flow. The inference of a minimum thermal budget required for a given metamorphism depends strongly on a knowledge of the PTt paths followed by rocks during the metamorphism. Discrimination between possible thermal regimes is greatly enhanced if portions of PTt paths, rather than single PT points, are available, and additional constraint is possible if these paths are supplemented by geochronological, structural and heat flow dat

Pressure—Temperature—Time Paths of Regional Metamorphism I. Heat Transfer during the Evolution of Regions of Thickened Continental Crust

The development of regional metamorphism in areas of thickened continental crust is investigated in terms of the major controls on regional-scale thermal regimes. These are: the total radiogenic heat supply within the thickened crust, the supply of heat from the mantle, the thermal conductivity of the medium and the length and time scales of erosion of the continental crust. The orogenic episode is regarded as consisting of a relatively rapid phase of crustal thickening, during which little temperature change occurs in individual rocks, followed by a lengthier phase of erosion, at the end of which the crust is at its original thickness. The principal features of pressure—temperature—time (PTt) paths followed by rocks in this environment are a period of thermal relaxation, during which the temperature rises towards the higher geotherm that would be supported by the thickened crust, followed by a period of cooling as the rock approaches the cold land surface. The temperature increase that occurs is governed by the degree of thickening of the crust, its conductivity and the time that elapses before the rock is exhumed sufficiently to be affected by the proximity of the cold upper boundary. For much of the parameter range considered, the heating phase encompasses a considerable portion of the exhumation (decompression) part of the PTt path. In addition to the detailed calculation of PTt paths we present an idealized model of the thickening and exhumation process, which may be used to make simple calculations of the amount of heating to be expected during a given thickening and exhumation episode and of the depth at which a rock will start to cool on its ascent path. An important feature of these PTt paths is that most of them lie within 50 °C of the maximum temperature attained for one third or more of the total duration of their burial and uplift, and for a geologically plausible range of erosion rates the rocks do not begin to cool until they have completed 20 to 40 per cent of the total uplift they experience. Considerable melting of the continental crust is a likely consequence of thickening of crust with an average continental geotherm. A companion paper discusses these results in the context of attempts to use metamorphic petrology data to give information on tectonic processe

Colonic Protein Fermentation and Promotion of Colon Carcinogenesis by Thermolyzed Casein

Thermolyzed casein is known to promote the growth of aberrant crypt foci (ACF) and colon cancer when it is fed to rats that have been initiated with azoxymethane. We speculated that the promotion was a consequence of increased colonic protein fermentation (i.e., that the thermolysis of the casein decreases its digestibility, increases the amount of protein reaching the colon, and increases colonic protein fermentation and that the potentially toxic products of this fermentation promote colon carcinogenesis). We found that the thermolysis of casein reduces its digestibility and increases colonic protein fermentation, as assessed by fecal ammonium and urinary phenol, cresol, and indol-3-ol. Thermolysis of two other proteins, soy and egg white protein, also increases colonic protein fermentation with increased fecal ammonia and urinary phenols, and thermolysis of all three proteins increases the levels of ammonia and butyric, valeric, and i-valeric acids in the cecal contents. We found, however, that the increased protein fermentation observed with thermolysis is not associated with pro-motion of colon carcinogenesis. With casein, the kinetics of protein fermentation with increasing thermolysis time are clearly different from the kinetics of promotion of ACF growth. The formation of the fermentation products was highest when the protein was thermolyzed for one hour, whereas promotion was highest for protein that had been thermolyzed for two or more hours. With soy and egg white, thermolysis increased colonic protein fermentation but did not promote colon carcinogenesis. Thus, although thermolysis of dietary casein increases colonic protein fermentation, products of this fermentation do not appear to be responsible for the promotion of colon carcinogenesis. Indeed, the results suggest that protein fermentation products do not play an important role in colon cancer promotion

The Liquid Line of Descent of Anhydrous, Mantle-Derived, Tholeiitic Liquids by Fractional and Equilibrium Crystallization—an Experimental Study at 1·0 GPa

Two series of anhydrous experiments have been performed in an end-loaded piston cylinder apparatus on a primitive, mantle-derived tholeiitic basalt at 1·0 GPa pressure and temperatures in the range 1060-1330°C. The experimental data provide constraints on phase equilibria, and solid and liquid compositions along the liquid line of descent of primary basaltic magmas differentiating in storage reservoirs located at the base of the continental crust. The first series are equilibrium crystallization experiments on a single basaltic bulk composition; the second series are fractionation experiments where near-perfect fractional crystallization was approached in a stepwise manner using 30°C temperature steps and starting compositions corresponding to the liquid composition of the previous, higher-temperature glass composition. Liquids in the fractional crystallization experiments evolve with progressive SiO2 increase from basalts to dacites, whereas the liquids in the equilibrium crystallization experiments remain basaltic and display only a moderate SiO2 increase accompanied by more pronounced Al2O3 enrichment. The principal phase equilibria controls responsible for these contrasting trends are suppression of the peritectic olivine + liquid = opx reaction and earlier plagioclase saturation in the fractionation experiments compared with the equilibrium experiments. Both crystallization processes lead to the formation of large volumes of ultramafic cumulates related to the suppression of plagioclase crystallization relative to pyroxenes at high pressures. This is in contrast to low-pressure fractionation of tholeiitic liquids, where early plagioclase saturation leads to the production of troctolites followed by (olivine-) gabbros at an early stage of differentiatio

Multiple sclerosis: time for early treatment with high-efficacy drugs

This review addresses current changes in the approach to treating patients with multiple sclerosis (MS). The widely practiced approach of utilizing agents with lower treatment efficacy (LETA) at onset with subsequent escalation has been challenged by new data suggesting that MS patients derive greater benefit when therapy is initiated with high-efficacy treatment agents (HETA). Several recent studies compared treatment efficacy and safety of early administration of HETA versus LETA. The results of randomized, double blind, phase III studies with LETA as a control arm and population-based larger and longer studies using propensity scoring, marginal structural modeling and weighted cumulative exposure analysis support the benefit of early treatment with HETA. Patients initiating their treatment with HETA, regardless of prognostic factors and MRI burden at baseline, showed significantly lower annualized relapse rate (ARR) and reduced disability progression in follow-up periods of up to 10–15 years. Moreover, the safety profile of recently approved HETA ameliorates concerns about off-target effects associated with a number of earlier high-efficacy drugs. Patient perception has also changed with an increasing preference for medication profiles that both improve symptoms and prevent disease progression. Accumulating data from randomized studies and the results of large population-based studies demonstrating short-term and longer-term patient benefits support the view that HETA should be more widely used. The adoption of early treatment with HETA capitalizes on a window of opportunity for anti-inflammatory drugs to maximally impact disease pathology and heralds a sea change in clinical practice toward pro-active management and away from a philosophy routed in generating clinical benefit as a consequence of treatment failure

Exploring the NRO Opportunity for a Hubble-sized Wide-field Near-IR Space Telescope -- NEW WFIRST

We discuss scientific, technical and programmatic issues related to the use of an NRO 2.4m telescope for the WFIRST initiative of the 2010 Decadal Survey. We show that this implementation of WFIRST, which we call "NEW WFIRST," would achieve the goals of the NWNH Decadal Survey for the WFIRST core programs of Dark Energy and Microlensing Planet Finding, with the crucial benefit of deeper and/or wider near-IR surveys for GO science and a potentially Hubble-like Guest Observer program. NEW WFIRST could also include a coronagraphic imager for direct detection of dust disks and planets around neighboring stars, a high-priority science and technology precursor for future ambitious programs to image Earth-like planets around neighboring stars.Comment: 76 pages, 26 figures -- associated with the Princeton "New Telescope Meeting

Oxytocin, a Novel Treatment for Methamphetamine Use Disorder

The treatment of substance abuse with oxytocin is a novel approach to a challenging public health issue that continues to contribute to a growing economic cost for societies worldwide. Methamphetamine addiction is one of the leading causes of mortality worldwide, and despite advances in understanding the neurobiology of methamphetamine addiction, treatment options are limited. There are no medications that the Food and Drug Administration currently approves for stimulant use disorder. Off-label use of therapies for stimulant misuse include antidepressants, anxiolytics, and milder stimulants as replacement agents. Due to the shortcomings of these attempts to treat a complicated psychiatric disorder, recent attention to oxytocin therapy (OT) has gained momentum in clinical studies as a possible therapy in the context of social stress, social anxiety, social cognition, and psychosis. Oxytocin produces enhanced connectivity between cortical regions. The results from studies in rodents with OT suggest that central neuromodulation of oxytocin may be beneficial across transition states of stimulant dependence and may alleviate intense withdrawal symptoms. Studies of oxytocin in the context of other drugs of abuse, including cocaine, cannabis, and alcohol, also support the potential of oxytocin to treat stimulant use disorder, methamphetamine type. Methamphetamine abuse continues to be a significant cause of distress and dysfunction throughout the world. The effects of oxytocin on methamphetamine use outlined in this review should act as a catalyst for further investigation into the efficacy of treating stimulant use disorder, methamphetamine type with oxytocin in humans. More human-based research should initiate studies involving the long-term efficacy, side effects, and patient selection

Atmospheric Acetaldehyde: Importance of Air-Sea Exchange and a Missing Source in the Remote Troposphere.

We report airborne measurements of acetaldehyde (CH3CHO) during the first and second deployments of the National Aeronautics and Space Administration (NASA) Atmospheric Tomography Mission (ATom). The budget of CH3CHO is examined using the Community Atmospheric Model with chemistry (CAM-chem), with a newly-developed online air-sea exchange module. The upper limit of the global ocean net emission of CH3CHO is estimated to be 34 Tg a-1 (42 Tg a-1 if considering bubble-mediated transfer), and the ocean impacts on tropospheric CH3CHO are mostly confined to the marine boundary layer. Our analysis suggests that there is an unaccounted CH3CHO source in the remote troposphere and that organic aerosols can only provide a fraction of this missing source. We propose that peroxyacetic acid (PAA) is an ideal indicator of the rapid CH3CHO production in the remote troposphere. The higher-than-expected CH3CHO measurements represent a missing sink of hydroxyl radicals (and halogen radical) in current chemistry-climate models