3,196 research outputs found
The Role of Phylogenetics as a Tool to Predict the Spread of Resistance
Drug resistance mutations emerge in genetic sequences of HIV through drug-selective pressure. Drug resistance can be transmitted. In this review we discuss phylogenetic methods used to study the emergence of drug resistance and the spread of resistant viruses
Origin of Low-Energy Excitations in Charge-Ordered Manganites
The low-energy excitations in the charge-ordered phase of polycrystalline
La0.25Ca0.75MnO3 are explored by frequency-domain terahertz spectroscopy. In
the frequency range from 4 cm^-1 to 700 cm^-1 (energies 0.4 meV to 90 meV) and
at temperatures down to 5 K, we do not detect any feature that can be
associated with the collective response of the spatially modulated charge
continuum. In the antiferromagnetically ordered phase, broad absorption bands
appear in the conductivity and permittivity spectra around 30 cm^-1 and 100
cm^-1 which are assigned to former acoustic phonons optically activated due to
a fourfold superstructure in the crystal lattice. Our results indicate that
characteristic energies of collective excitations of the charge-ordered phase
in La0:25Ca0:75MnO3, if any, lie below 1 meV. At our lowest frequencies of only
few wavenumbers a strong relaxation is observed above 100 K connected to the
formation of the charge-ordered state.Comment: 5 pages, 3 figure
A Tri-National program for estimating the link between snow resources and hydrological droughts
To evaluate how summer low flows and droughts are affected by the winter
snowpack, a Tri-National effort will analyse data from three catchments:
Alpbach (Prealps, central Switzerland), Gudjaretis-Tskali (Little Caucasus,
central Georgia), and Kamenice (Jizera Mountains, northern Czech Republic).
Two GIS-based rainfall-runoff models will simulate over 10 years of runoff in
streams based on rain and snowfall measurements, and further meteorological
variables. The models use information on the geographical settings of the
catchments together with knowledge of the hydrological processes of runoff
generation from rainfall, looking particularly at the relationship between
spring snowmelt and summer droughts. These processes include snow
accumulation and melt, evapotranspiration, groundwater recharge in spring
that contributes to (the) summer runoff, and will be studied by means of the
environmental isotopes 18O and 2H. Knowledge about the isotopic
composition of the different water sources will allow to identify the flow
paths and estimate the residence time of snow meltwater in the subsurface and
its contribution to the stream. The application of the models in different
nested or neighbouring catchments will explore their potential for further
development and allow a better early prediction of low-flow periods in
various mountainous zones across Europe. The paper presents the planned
activities including a first analysis of already available dataset of
environmental isotopes, discharge, snow water equivalent and modelling
experiments of the (already) available datasets
Neurophysiological Changes in Patients with Discirculatory Encephalopathy Associated with Ischemic Optic Neuropathy
Background. The most common chronic cerebrovascular pathology is dyscirculatory encephalopathy, in which a decrease in blood supply due to damage to brachiocephalic vessels leads to damage to brain substances and analyzers, including visual, with the possible development of severe damage in the form of ischemic optic neuropathy. Many studies have been devoted to the relationship between atherosclerotic damage to the neck vessels and ischemic damage to the visual organ, but little attention has been paid to the study of the functional activity of the altered visual analyzer in patients with dyscirculatory encephalopathy, and the results are scattered. Aim. To conduct a comparative analysis of changes in neurophysiological parameters of the brain and visual analyzer in patients with dyscirculatory encephalopathy and patients with a combination of dyscirculatory encephalopathy and ischemic optic neuropathy. Materials and methods. 34 patients with the 2nd stage of dyscirculatory encephalopathy were examined and divided into two groups based on the presence/absence of ischemic optic neuropathy of various prescription periods. All patients underwent ultrasound scanning of neck vessels, visual fields determination, electroretinography, visual evoked potentials, and electroencephalogram. Results. The results revealed changes in a number of indicators in the group of patients with a combination of two diseases: more pronounced atherosclerotic lesion of brachiocephalic vessels, a decrease in the amplitude and the alpharhythm prevalence index, a decrease in oscillatory potentials, a change in latency and amplitudes the visual analyzer according, lengthening of time indicators with a simultaneous decrease in amplitudes and depression of retinal sensitivity. Conclusion. Patients with dyscirculatory encephalopathy complicated by ischemic optic neuropathy have a combined lesion of the brain and visual analyzer, which determines the severity of the detected changes and requires a comprehensive multidisciplinary approach to the treatment of these patients
Overview of experimental results in PbPb collisions at sqrt{s_NN} = 2.76 TeV by the CMS Collaboration
The CMS experiment at the LHC is a general-purpose apparatus with a set of
large acceptance and high granularity detectors for hadrons, electrons, photons
and muons, providing unique capabilities for both proton-proton and ion-ion
collisions. The data collected during the November 2010 PbPb run at sqrt{s_NN}
= 2.76 TeV was analyzed and multiple measurements of the properties of the hot
and dense matter were obtained. Global event properties, detailed study of jet
production and jet properties, isolated photons, quarkonia and weak bosons were
measured and compared to pp data and Monte Carlo simulations.Comment: 8 pages, 10 figures, proceedings for Quark Matter 2011, Annecy,
France, May 23-28, 201
Blogs as a Resource for Forming Communication Skills of Foreign Students (by the Example of the Course "Russian Language for Bloggers")
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π±Π»ΠΎΠ³Π° Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΈ ΠΎΠ±ΡΡΠ΅Π½ΠΈΠΈ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΠΌ ΡΠ·ΡΠΊΠ°ΠΌ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ ΡΡΡΡΠΊΠΎΠΌΡ ΠΊΠ°ΠΊ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΠΎΠΌΡ, ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΠΈΡΡΠ²Π°ΡΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΡΠΈΠΏΡ Π·Π°Π΄Π°Π½ΠΈΠΉ Π½Π° Π°ΠΊΡΠΈΠ²ΠΈΠ·Π°ΡΠΈΡ ΡΠ°Π·Π½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΡΠ΅ΡΠ΅Π²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΡΠΎΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Π±Π»ΠΎΠ³ΠΎΠ². ΠΡΡΠ»Π΅Π΄ΡΡΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π±Π»ΠΎΠ³ΠΎΠ² Π½Π° Π·Π°Π½ΡΡΠΈΡΡ
ΠΏΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΠΌ ΡΠ·ΡΠΊΠ°ΠΌ, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ ΡΡΡΡΠΊΠΎΠΌΡ ΡΠ·ΡΠΊΡ ΠΊΠ°ΠΊ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΠΎΠΌΡ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°Π²ΡΠΊΠΎΠ² Π°ΡΠ΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ½ΠΎΡΠ·ΡΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΈ ΡΡΠ°ΡΠΈΡ
ΡΡ.The article discusses the possibility of using a blog in the educational process when teaching foreign languages, in particular Russian as a foreign language, and also describes various types of tasks for the activation of different types of speech activity, compiled on the basis of blog materials. The advantages of using blogs in the classroom for teaching foreign languages, namely Russian as a foreign language, for the development of listening skills and the formation of foreign language communicative competence of students are investigated
ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΈΠΉ Π΄ΠΈΠ·Π°ΠΉΠ½ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ ΠΏΠΎΡ ΡΠ΄Π½ΠΈΡ N-ΡΠ΅Π½ΡΠ»Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π·Π° ΠΌΠΎΠ΄Π΅Π»Π»Ρ de nova
Most QSAR methods are based on determination of dependence of different types of biological activity of compounds on their physicochemical parameters, which determination is experimentally quite difficult, while those compounds that are calculated theoretically often have systematic deviations.Aim. To determine the increments of substituents in isostructural series of hydrazides and thiosemicarbazides of substituted N-phenylanthranilic acids for their anti-inflammatory activity by the empirical method on the de nova model.Results and discussion. The study was conducted for 18 thiosemicarbazide (batch 1) and 15 hydrazides (batch 2) of substituted N-phenylanthranilic acid. The increments calculated show that introduction of substituents in the anthranilic moiety of the thiosemicarbazide molecule increases the anti-inflammatory activity. The increments of substituents in the non-anthranilic fragment of the molecule have different signs and values, depending on the nature and position of the radical. Introduction of substituents (Cl-, NO2-) into the para-position of the anthranilic fragment of the molecule of N-phenylantranilic acid hydrazide increases the anti-inflammatory activity, while introduction of various substituents into the non-anthranilic fragment of the molecule causes both an increase and a decrease in lg P.Experimental part. The study of the anti-inflammatory activity was performed on the βformalin edemaβ model in rats using the oncometric method. The substances were administered orally in the form of a fine suspension stabilized by the emulsifier Tween-80 in the doses of 50 mg/kg of the animal body weight. The reference drug indomethacin was administered in the dose of 50 mg/kg.Conclusions. The increments of substituents in isostructural series of hydrazides and thiosemicarbazides of substituted N-phenylanthranilic acids have been determined by the empirical method. The dependence of the increments on the nature and position of substituents in molecules has been analyzed.ΠΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ QSAR-ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π±Π°Π·ΠΈΡΡΠ΅ΡΡΡ Π½Π° ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΎΡ ΠΈΡ
ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ², ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΡΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΄ΠΎΠ²ΠΎΠ»ΡΠ½ΠΎ Π·Π°ΡΡΡΠ΄Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ, Π° ΡΠ°ΡΡΡΠΈΡΠ°Π½Π½ΡΠ΅ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π°ΡΠ°ΡΡΡΡ ΠΈΠΌΠ΅ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΡ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Β«de novaΒ» ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΈΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΡ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² ΠΈΠ·ΠΎΡΡΡΡΠΊΡΡΡΠ½ΡΡ
ΡΡΠ΄Π°Ρ
Π³ΠΈΠ΄ΡΠ°Π·ΠΈΠ΄ΠΎΠ² ΠΈ ΡΠΈΠΎΡΠ΅ΠΌΠΈΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΠΎΠ² Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
N-ΡΠ΅Π½ΠΈΠ»Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΊΠΈΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ.Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π΄Π»Ρ 18 ΡΠΈΠΎΡΠ΅ΠΌΠΈΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΠΎΠ² (1 ΡΠ΅ΡΠΈΡ) ΠΈ 15 Π³ΠΈΠ΄ΡΠ°Π·ΠΈΠ΄ΠΎΠ² (2 ΡΠ΅ΡΠΈΡ) Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
N-ΡΠ΅Π½ΠΈΠ»Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ. Π Π°ΡΡΡΠΈΡΠ°Π½Π½ΡΠ΅ ΠΈΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΡ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ, ΡΡΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΡΡ ΡΠ°ΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ ΡΠΈΠΎΡΠ΅ΠΌΠΈΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΠΎΠ² ΡΡΠΈΠ»ΠΈΠ²Π°Π΅Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΡ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² Π½Π΅Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΠΎΠΌ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ ΠΈΠΌΠ΅ΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Π·Π½Π°ΠΊΠΈ ΠΈ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ, Π·Π°Π²ΠΈΡΡΡΠΈΠ΅ ΠΎΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΈ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΡΠ°Π΄ΠΈΠΊΠ°Π»Π°. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ (Cl-, NO2-) Π² ΠΏΠ°ΡΠ°-ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ° ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Π³ΠΈΠ΄ΡΠ°Π·ΠΈΠ΄Π° N-ΡΠ΅Π½ΠΈΠ»Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² Π½Π΅Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΡΠΉ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΊΠ°ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅, ΡΠ°ΠΊ ΠΈ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ lg Π.Β Β Β Β Β Β Β Β Β Β Β Β ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Β«ΡΠΎΡΠΌΠ°Π»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΎΡΠ΅ΠΊΠ°Β» Ρ ΠΊΡΡΡ ΠΎΠ½ΠΊΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ. ΠΠ΅ΡΠ΅ΡΡΠ²Π° Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π² Π²ΠΈΠ΄Π΅ ΡΠΎΠ½ΠΊΠΎΠ΄ΠΈΡΠΏΠ΅ΡΡΠ½ΠΎΠΉ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΈ, ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΌΡΠ»ΡΠ³Π°ΡΠΎΡΠΎΠΌ ΡΠ²ΠΈΠ½ΠΎΠΌ-80 Π² Π΄ΠΎΠ·Π°Ρ
50 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½ Π²Π²ΠΎΠ΄ΠΈΠ»ΡΡ Π² Π΄ΠΎΠ·Π΅ 50 ΠΌΠ³/ΠΊΠ³. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΈΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΡ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² ΠΈΠ·ΠΎΡΡΡΡΠΊΡΡΡΠ½ΡΡ
ΡΡΠ΄Π°Ρ
ΡΠΈΠΎΡΠ΅ΠΌΠΈΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΠΎΠ² ΠΈ Π³ΠΈΠ΄ΡΠ°Π·ΠΈΠ΄ΠΎΠ² Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
N-ΡΠ΅Π½ΠΈΠ»Π°Π½ΡΡΠ°Π½ΠΈΠ»ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π° Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΈΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΎΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΈ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π°Ρ
.ΠΡΠ»ΡΡΡΡΡΡ QSAR-ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Π±Π°Π·ΡΡΡΡΡΡ Π½Π° Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½Ρ Π·Π°Π»Π΅ΠΆΠ½ΠΎΡΡΡ ΡΡΠ·Π½ΠΈΡ
Π²ΠΈΠ΄ΡΠ² Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΏΠΎΠ»ΡΠΊ Π²ΡΠ΄ ΡΡ
ΡΡΠ·ΠΈΠΊΠΎ-Ρ
ΡΠΌΡΡΠ½ΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡΠ², Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ ΡΠΊΠΈΡ
Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎ Π΄ΠΎΡΠΈΡΡ ΡΡΡΡΠ΄Π½Π΅Π½Π΅, Π° ΡΠΎΠ·ΡΠ°Ρ
ΠΎΠ²Π°Π½Ρ Π²ΠΎΠ½ΠΈ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ½ΠΎ Ρ Π½Π°ΠΉΡΠ°ΡΡΡΡΠ΅ ΠΌΠ°ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ½Ρ Π²ΡΠ΄Ρ
ΠΈΠ»Π΅Π½Π½Ρ.ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ β Π΅ΠΌΠΏΡΡΠΈΡΠ½ΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π·Π° ΠΌΠΎΠ΄Π΅Π»Π»Ρ Β«de novaΒ» Π²ΠΈΠ·Π½Π°ΡΠΈΡΠΈ ΡΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠΈ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Π² ΡΠ·ΠΎΡΡΡΡΠΊΡΡΡΠ½ΠΈΡ
ΡΡΠ΄Π°Ρ
Π³ΡΠ΄ΡΠ°Π·ΠΈΠ΄ΡΠ² ΡΠ° ΡΡΠΎΡΠ΅ΠΌΡΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΡΠ² Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
N-ΡΠ΅Π½ΡΠ»Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ Π΄ΠΎ ΡΡ
ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ.Β Β Β Β Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π·Π΄ΡΠΉΡΠ½ΡΠ²Π°Π»ΠΎΡΡ Π΄Π»Ρ 18 ΡΡΠΎΡΠ΅ΠΌΡΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΡΠ² (1 ΡΠ΅ΡΡΡ) ΡΠ° 15 Π³ΡΠ΄ΡΠ°Π·ΠΈΠ΄ΡΠ² (2 ΡΠ΅ΡΡΡ) Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
N-ΡΠ΅Π½ΡΠ»Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ. Π ΠΎΠ·ΡΠ°Ρ
ΠΎΠ²Π°Π½Ρ ΡΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠΈ ΠΏΠΎΠΊΠ°Π·ΡΡΡΡ, ΡΠΎ Π²Π²Π΅Π΄Π΅Π½Π½Ρ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Π΄ΠΎ Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΎΡ ΡΠ°ΡΡΠΈΠ½ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ ΡΡΠΎΡΠ΅ΠΌΡΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΡΠ² ΠΏΡΠ΄ΡΠΈΠ»ΡΡ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ. ΠΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠΈ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Ρ Π½Π΅Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΎΠΌΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ ΠΌΠ°ΡΡΡ ΡΡΠ·Π½Ρ Π·Π½Π°ΠΊΠΈ ΡΠ° Π²Π΅Π»ΠΈΡΠΈΠ½ΠΈ, ΡΠΎ Π·Π°Π»Π΅ΠΆΠ°ΡΡ Π²ΡΠ΄ ΠΏΡΠΈΡΠΎΠ΄ΠΈ ΡΠ° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ ΡΠ°Π΄ΠΈΠΊΠ°Π»Ρ. ΠΠ²Π΅Π΄Π΅Π½Π½Ρ Π΄ΠΎ Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ Π³ΡΠ΄ΡΠ°Π·ΠΈΠ΄Ρ N-ΡΠ΅Π½ΡΠ»Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Ρ ΠΏΠ°ΡΠ°-ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² (Cl-, NO2-) ΠΏΡΠ΄Π²ΠΈΡΡΡ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ, Π° Π²Π²Π΅Π΄Π΅Π½Π½Ρ ΡΡΠ·Π½ΠΈΡ
Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Ρ Π½Π΅Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΈΠΉ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°Ρ ΡΠΊ Π·Π±ΡΠ»ΡΡΠ΅Π½Π½Ρ, ΡΠ°ΠΊ Ρ Π·ΠΌΠ΅Π½ΡΠ΅Π½Π½Ρ lg Π.Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β Β ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π° ΡΠ°ΡΡΠΈΠ½Π°. ΠΠΈΠ²ΡΠ΅Π½Π½Ρ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ Β«ΡΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ²ΠΎΠ³ΠΎ Π½Π°Π±ΡΡΠΊΡΒ» Ρ ΡΡΡΡΠ² ΠΎΠ½ΠΊΠΎΠΌΠ΅ΡΡΠΈΡΠ½ΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ. Π Π΅ΡΠΎΠ²ΠΈΠ½ΠΈ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Ρ Π²ΠΈΠ³Π»ΡΠ΄Ρ ΡΠΎΠ½ΠΊΠΎΠ΄ΠΈΡΠΏΠ΅ΡΠ³ΠΎΠ²Π°Π½ΠΎΡ ΡΡΡΠΏΠ΅Π½Π·ΡΡ, ΡΡΠ°Π±ΡΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΎΡ Π΅ΠΌΡΠ»ΡΠ³Π°ΡΠΎΡΠΎΠΌ ΡΠ²ΡΠ½ΠΎΠΌ-80 Ρ Π΄ΠΎΠ·Π°Ρ
50 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΠΈ ΡΡΠ»Π° ΡΠ²Π°ΡΠΈΠ½. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΏΠΎΡΡΠ²Π½ΡΠ½Π½Ρ ΡΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½ Π²Π²ΠΎΠ΄ΠΈΠ²ΡΡ Ρ Π΄ΠΎΠ·Ρ 50 ΠΌΠ³/ΠΊΠ³.Β Β Β Β Β Β Β Β Β Β Β Β ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΠΌΠΏΡΡΠΈΡΠ½ΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Ρ ΡΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΠΈ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Π² ΡΠ·ΠΎΡΡΡΡΠΊΡΡΡΠ½ΠΈΡ
ΡΡΠ΄Π°Ρ
ΡΡΠΎΡΠ΅ΠΌΡΠΊΠ°ΡΠ±Π°Π·ΠΈΠ΄ΡΠ² ΡΠ° Π³ΡΠ΄ΡΠ°Π·ΠΈΠ΄ΡΠ² Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
N-ΡΠ΅Π½ΡΠ»Π°Π½ΡΡΠ°Π½ΡΠ»ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ. ΠΡΠΎΠ°Π½Π°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΎ Π·Π°Π»Π΅ΠΆΠ½ΡΡΡΡ ΡΠ½ΠΊΡΠ΅ΠΌΠ΅Π½ΡΡΠ² Π²ΡΠ΄ ΠΏΡΠΈΡΠΎΠ΄ΠΈ ΡΠ° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π°Ρ
ORGANIZATION OF ANTIEPIDEMIC MEASURES AT THE PLACE OF Β«ATYPICAL PNEUMONIAΒ» PATIENT RESIDING
Antiepidemic measures in Blagoveshchensk City of Amurskaya Province were carried out among personsΒ contacted with a patient suspected to Β«atypical pneumoniaΒ» (further diagnosis was confirmed by laboratoryΒ methods). Chinese citizens were isolated at the hotel (at the place of their residing); close relatives of the patient were accommodated in the isolation ward of the Regional infectious hospital.Β Russians were kept underΒ observation at the place of their residing. The efficiency of the performed measures is marked
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