Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data

There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a preference-based index from a condition specific measure relating to sexual health and to compare the results to values generated from time trade-off valuation (TTO). The DCE data were analysed using a random effects probit model and the DCE predicted values were rescaled according to the highest and lowest predicted TTO values corresponding to the best and worst SQOL health states respectively. The rank data were analysed using a rank ordered logit model and re-scaled using two alternative methods. Firstly, re-scaling the rank predicted values using identical methods to those employed for DCE and secondly, re-scaling the rank model coefficients by dividing each level coefficient by the coefficient relating to death. The study raises some important issues about the use of ordinal data to produce cardinal health state valuations

Hybridized polymer matrix composites

The extent to which graphite fibers are released from resin matrix composites that are exposed to fire and impact conditions was determined. Laboratory simulations of those conditions that could exist in the event of an aircraft crash and burn situation were evaluated. The effectiveness of various hybridizing concepts in preventing this release of graphite fibers were also evaluated. The baseline (i.e., unhybridized) laminates examined were prepared from commercially available graphite/epoxy, graphite/polyimide, and graphite/phenolic materials. Hybridizing concepts investigated included resin fillers, laminate coatings, resin blending, and mechanical interlocking of the graphite reinforcement. The baseline and hybridized laminates' mechanical properties, before and after isothermal and humidity aging, were also compared. It was found that a small amount of graphite fiber was released from the graphite/epoxy laminates during the burn and impact conditions used in this program. However, the extent to which the fibers were released is not considered a severe enough problem to preclude the use of graphite reinforced composites in civil aircraft structure. It also was found that several hybrid concepts eliminated this fiber release. Isothermal and humidity aging did not appear to alter the fiber release tendencies

Manufacturing processes for fabricating graphite/PMR 15 polyimide structural elements

Investigations were conducted to obtain commercially available graphite/PMR-15 polyimide prepreg, develop an autoclave manufacturing process, and demonstrate the process by manufacturing structural elements. Controls were established on polymer, prepreg, composite fabrication, and quality assurance, Successful material quality control and processes were demonstrated by fabricating major structural elements including flat laminates, hat sections, I beam sections, honeycomb sandwich structures, and molded graphite reinforced fittings. Successful fabrication of structural elements and simulated section of the space shuttle aft body flap shows that the graphite/PMR-15 polyimide system and the developed processes are ready for further evaluation in flight test hardware

Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data

There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a preference-based index from a condition specific measure relating to sexual health and to compare the results to values generated from time trade-off valuation (TTO). The DCE data were analysed using a random effects probit model and the DCE predicted values were rescaled according to the highest and lowest predicted TTO values corresponding to the best and worst SQOL health states respectively. The rank data were analysed using a rank ordered logit model and re-scaled using two alternative methods. Firstly, re-scaling the rank predicted values using identical methods to those employed for DCE and secondly, re-scaling the rank model coefficients by dividing each level coefficient by the coefficient relating to death. The study raises some important issues about the use of ordinal data to produce cardinal health state valuations.sexual health, quality of life, preference-based measures

Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data

There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a preference-based index from a condition specific measure relating to sexual health and to compare the results to values generated from time trade-off valuation (TTO). The DCE data were analysed using a random effects probit model and the DCE predicted values were rescaled according to the highest and lowest predicted TTO values corresponding to the best and worst SQOL health states respectively. The rank data were analysed using a rank ordered logit model and re-scaled using two alternative methods. Firstly, re-scaling the rank predicted values using identical methods to those employed for DCE and secondly, re-scaling the rank model coefficients by dividing each level coefficient by the coefficient relating to death. The study raises some important issues about the use of ordinal data to produce cardinal health state valuations

Does lighting affect pedestrian flows? A pilot study in Lund, Market Harborough and Dublin

A study records pedestrian footfalls in Lund, Dublin and Market Harborough during the day and after dark, either side of the Autumn 2016 clock change, using the change of end of civil twilight time to measure the effect of different lighting levels at the same clock time on footfall rates. Examination of total footfalls on weekdays and at weekends found significant decreases in counts after the clock change, on 5/6 sites on weekdays and half the sites at weekends. Further analysis found that the percentage decrease in the counts in the test period (same time/day of the week, light one week, dark the next) was more than in the control period (same time/day of the week, light both weeks), in 79% of counting sessions. The findings demonstrate higher reduction in footfalls on weekdays in mixed use areas, such as the sites selected in Dublin, and on Sundays in non-central locations

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells

This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanisms regulating these responses are unknown. Here, we report that deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum proinflammatory cytokines but also impaired antigen receptor-induced proliferation of B and T cells. Egr2- and Egr3-defective B and T cells had hyperactive signal transducer and activator of transcription-1 (STAT1) and STAT3 while antigen receptor-induced activation of transcription factor AP-1 was severely impaired. We discovered that Egr2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 (SOCS1) and SOCS3, inhibitors of STAT1 and STAT3, and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells. Thus, Egr2 and Egr3 regulate B and T cell function in adaptive immune responses and homeostasis by promoting antigen receptor signaling and controlling inflammation.Arthritis Research U

The Role of the Energy Audit in Reducing Building Energy Consumption

The application of the energy audit process to the reduction of energy consumption in buildings is described. A methodology for selecting from an inventory of buildings those buildings which are candidates for a detailed energy audit is presented, and the analysis of energy consumption and cost savings resulting from implementation of energy conservation opportunities (ECO\u27s) is detailed. A practical payback period formula is presented which includes escalating energy costs. The audit and analysis procedures are illustrated by two case studies

A Basic Study on Temporal Parameter Estimation of Wheelchair Propulsion based on Measurement of Upper Limb Movements Using Inertial Sensors

Wheelchairs are the most widely used assistive device to aid activities of daily living (ADL) for disabled people. However, manual pushing of a wheelchair frequently leads to overuse of upper extremities causing shoulder pain and carpal tunnel syndrome. The purpose of this study was to test a novel method of estimating temporal parameters of wheelchair propulsion using inertial sensors. In this paper, normalized coordinate values of the vector defined on the upper arm were calculated from an inertial sensor attached on the upper arm. The number of strokes and push cycle timings including duration of propulsion and recovery phases were estimated for steady state wheelchair propulsion. This estimation was completed using a novel vector-based approach and a previously published resultant acceleration method; both were compared to timings measured using the SmartWheel. Measurements were performed on level and sloped surfaces with 10 able bodied subjects. The vector-based method improved estimation of the number of strokes when compared to the resultant acceleration method. However, the push cycle was estimated with better accuracy by the resultant acceleration method. Therefore, a combination of the vector-based and the resultant acceleration methods is proposed to ensure more accurate estimation of temporal parameters. The results suggest inertial sensors can be used to measure wheelchair activity accurately and reliably

Effect of maternal cold exposure and nutrient restriction on insulin-like growth factor sensitivity in adipose tissue of newborn sheep

Adipose tissue mass in the newborn is determined in part by insulin-like growth factor (IGF)s, which are dependent on the maternal nutritional and metabolic environment during late gestation. The present study was designed to determine whether maternal cold exposure (CE) commencing in mid gestation could modulate some of the adaptive effects of nutrient restriction in late gestation on adipose tissue endocrine sensitivity in the resulting offspring. Twenty eight pregnant sheep were entered into the study and were either shorn, i.e. cold exposed, from 70 days gestation (term = 147 days), or remained unshorn, and were fed either their total calculated metabolisable energy (ME) requirements for body weight and pregnancy from 110 days gestation or 50% of this amount (n=7 per group). Adipose tissue was sampled from the offspring at one day of age and the mRNA abundance for IGF-I, II their receptors (R) and GH secretagogue receptor-1a (GHSR-1a) were determined. CE mothers produced larger offspring with more perirenal adipose tissue, an adaptation prevented by maternal nutrient restriction. Nutrient restriction in unshorn mothers increased IGF-I and IIR mRNA abundance. The mRNA abundances for IGF-I, II and IIR in adipose tissue were reduced by CE, adaptations independent of maternal food intake, whereas CE plus nutrient restriction increased GHSR-1a mRNA. In conclusion, maternal nutrient restriction with or without CE has very different effects on IGF sensitivity of adipose tissue and may act to ensure adequate fat stores are present in the newborn in the face of very different maternal endocrine and metabolic environments