岡山県立大学2016年入学生の英語学習に対する認識

This study looks at changing perceptions of English-language education and e-learning among first-year students at Okayama Prefectural University (OPU) after completing a full year of English classes. We conducted a questionnaire-based survey at the beginning and end of the 2016 academic year, and the results show that although students had similar beliefs about learning English, their desire to learn English had decreased by the end of the year. Furthermore, while only slightly less than half of students felt that the materials were effective, more than half did not like using them.本稿は、岡山県立大学2016年度に入学した学生を対象として、大学入学当初と2016年度末に学習者ビリーフ（学習に対する態度・不安・願望）を調査した報告である。主な結果として、多くの学習者が、１年次における英語学習を終えた後、英語学習に対する意欲を低下させていることが明らかになった。また、e-learning学習は効果的であると認めながらも、好きではないと回答した学生が多かった。教師は、学生の英語学習に対するニーズが何であるのかを常に意識していかなければいけないことが示唆された

Open Voice 改訂の歩み : 英語学習者のアウトプット力増強に向けたアクティブ・ラーニングのために

An important key to success at developing communicative abilities in a second language is actively practicing the four communication skills (reading, writing, speaking, and listening). With this in mind, the Open Voice system was developed to support students’ active engagement with the skills of writing and speaking. This paper explains how the Open Voice system was developed and revised in order to increase English Language Learner output.外国語習得においては、読む、書く、聞く、話す、の4技能を能動的に練習することが、コミュニケーション能力を身につけるために重要な鍵となる。岡山県立大学が独自に開発した英語教材 Open Voiceは、ライティングとスピーキングのスキルを高めるため、学生が積極的に学習に取り組めるようデザインされている。小論では、 英語学習者のアウトプット力増強に向け Open Voiceがどのように改訂されてきたかを述べるとともに、アクティブ・ラーニングの要素が効果的に導入されていることを明らかにした

Report on 2016 Okayama Prefectural University Students\u27 Beliefs in Learning English

本稿は、岡山県立大学1 年生を対象として、大学入学当初の5 月に学習者ビリーフを実施した報告である。平成27 年度から新しい英語プログラムであるEnglish Language Program (ELP) が始まった。この報告は、ELP を始めるにあたって、岡山県立大学に入学した1 年生が、英語学習に対して、どのような学習者ビリーフを持っているのかを量的に調査したものである。主な結果として、大半の学生が、統合的および道具的動機を持っていた。また、入学当初には、スピーキングに対して、不安を抱えていたことも明らかにされた

現在の英語カリキュラムと新入生の学習者ビリーフに基づく発展的提案

In order to provide students with good teaching, the curriculum needs to be reviewed and revised periodically. Even minor changes can be of benefit. To prepare a better curriculum for students, teachers should know students’ needs and wants. In this report, the present English curriculum at Okayama Prefectural University is described. The present curriculum aims to improve students’ four skills: listening, reading, speaking, and writing in addition to increasing vocabulary and grammar knowledge. Then, the results of a survey on 2018 first-year students’ beliefs regarding learning English are reported. Students’ beliefs include attitude toward English learning, motivation, anxiety, and expectation. Last, based on the results of the survey, the strengths and weaknesses of the present curriculum are discussed.平成30年度に実施された英語カリキュラムを説明し、平成30年度入学生の入学直後の学習者ビリーフ（学習への期待、意欲、不安など）を調査した。調査の結果、3つの学部から構成される岡山県立大学は、学部ごとに、学習者ビリーフが大きく異なることが明らかになった。語学教育推進室は、全学を対象とした統一英語カリキュラムを実施しているが、学部ごとに、学生のニーズに合わせた英語カリキュラムを工夫していく必要がある

Barrier-to-Autointegration Factor Proteome Reveals Chromatin-Regulatory Partners

Nuclear lamin filaments and associated proteins form a nucleoskeletal (“lamina”) network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans. Lamina defects cause human disease (“laminopathies”) and are linked to aging. Barrier-to-autointegration factor (BAF) is a mobile and essential component of the nuclear lamina that binds directly to histones, lamins and LEM-domain proteins, including the inner nuclear membrane protein emerin, and has roles in chromatin structure, mitosis and gene regulation. To understand BAF's mechanisms of action, BAF associated proteins were affinity-purified from HeLa cell nuclear lysates using BAF-conjugated beads, and identified by tandem mass spectrometry or independently identified and quantified using the iTRAQ method. We recovered A- and B-type lamins and core histones, all known to bind BAF directly, plus four human transcription factors (Requiem, NonO, p15, LEDGF), disease-linked proteins (e.g., Huntingtin, Treacle) and several proteins and enzymes that regulate chromatin. Association with endogenous BAF was independently validated by co-immunoprecipitation from HeLa cells for seven candidates including Requiem, poly(ADP-ribose) polymerase 1 (PARP1), retinoblastoma binding protein 4 (RBBP4), damage-specific DNA binding protein 1 (DDB1) and DDB2. Interestingly, endogenous BAF and emerin each associated with DDB2 and CUL4A in a UV- and time-dependent manner, suggesting BAF and emerin have dynamic roles in genome integrity and might help couple DNA damage responses to the nuclear lamina network. We conclude this proteome is a rich source of candidate partners for BAF and potentially also A- and B-type lamins, which may reveal how chromatin regulation and genome integrity are linked to nuclear structure

Völkisch und sozial? : Neonazistische Agitation gegen die neue EU-Freizügigkeit für Arbeitnehmerinnen

Wnt/β-catenin signalling pathway is crucial for the formation of many tissues and organs during development. In recent years, this pathway has also been found to regulate the biology of stem cells in the intestine and probably in other organs in adult life. Abnormal activation of Wnt/β-catenin signalling, which controls the expression of a high number of genes, is critical for the initiation and progression of most colorectal cancers. In line with this, the gene expression signature induced by activation of the Wnt/β-catenin pathway defines the intestinal stem cells present at the bottom of the crypts and also colon cancer stem cells. This supports the importance of inhibitors of the Wnt/β-catenin pathway as potential agents in colorectal cancer therapy. However, the complexity, wide activity in the organism modulating the biology of several cell types, and characteristics of this pathway have delayed the identification of suitable targets and so, the development of such inhibitors that are only now reaching the clinic.Peer reviewe