Evidence for Resistance Training as a Treatment Therapy in Obesity

Over the last decade, investigators have paid increasing attention to the effects of resistance training (RT) on several metabolic syndrome variables. Evidence suggests that skeletal muscle is responsible for up to 40% of individuals' total body weight and may be influential in modifying metabolic risk factors via muscle mass development. Due to the metabolic consequences of reduced muscle mass, it is understood that normal aging and/or decreased physical activity may lead to a higher prevalence of metabolic disorders. The purpose of this review is to (1) evaluate the potential clinical effectiveness and biological mechanisms of RT in the treatment of obesity and (2) provide up-to-date evidence relating to the impact of RT in reducing major cardiovascular disease risk factors (including dyslipidaemia and type 2 diabetes). A further aim of this paper is to provide clinicians with recommendations for facilitating the use of RT as therapy in obesity and obesity-related metabolic disorders

3D modeling of indoor environments by a mobile platform with a laser scanner and panoramic camera

One major challenge of 3DTV is content acquisition. Here, we present a method to acquire a realistic, visually convincing D model of indoor environments based on a mobile platform that is equipped with a laser range scanner and a panoramic camera. The data of the 2D laser scans are used to solve the simultaneous lo- calization and mapping problem and to extract walls. Textures for walls and floor are built from the images of a calibrated panoramic camera. Multiresolution blending is used to hide seams in the gen- erated textures. The scene is further enriched by 3D-geometry cal- culated from a graph cut stereo technique. We present experimental results from a moderately large real environment.

Oncoid growth and distribution controlled by sea-level fluctuations and climate (Late Oxfordian, Swiss Jura Mountains)

Abundant lagoonal oncoids occur in the Late Oxfordian Hauptmumienbank Member of the Swiss Jura Mountains. Four oncoid types are observed in the studied sections and classified according to the oncoid surface morphology, the structure and composition of the cortex, and the texture and fauna of the encasing sediment. Micrite-dominated oncoids (types 1 and 2) have a smooth surface. Type 1 has a rather homogeneous cortex and occurs in moderate-energy environments. Type 2 presents continuous or discontinuous micritic laminae. It is associated with a low-diversity fauna and occurs in high-energy facies. Bacinella and Lithocodium oncoids (types 3 and 4) display a lobate surface. They are dominated by microencrusters (Bacinella irregularis and Lithocodium aggregatum) and are found in low-energy facies. The stratigraphic and spatial distribution of these oncoid types shows a correlation with the sequence-stratigraphic evolution of the studied interval, and thus with relative sea-level fluctuations. It can be shown that these sea-level fluctuations were controlled by orbital cycles with 100- and 20-kyr periodicities. At the scale of 100- and 20-kyr sequences, types 1 and 2 oncoids are preferentially found around sequence boundaries and in transgressive deposits, while types 3 and 4 oncoids are preferentially found around maximum floodings and in highstand deposits. This implies that changes of water energy and water depth were direct controlling factors. Discrepancies in oncoid distribution point to additional controlling factors. Platform morphology defines the distribution and type of the lagoon where the oncoids flourished. A low accumulation rate is required for oncoid growth. Additionally, humidity changes in the hinterland act on the terrigenous influx, which modifies water transparency and trophic level and thus plays a role in the biotic composition and diversity in the oncoid corte

Communicating Synthetic Biology: from the lab via the media to the broader public

We present insights from a study on communicating Synthetic Biology conducted in 2008. Scientists were invited to write press releases on their work; the resulting texts were passed on to four journalists from major Austrian newspapers and magazines. The journalists in turn wrote articles that were used as stimulus material for eight group discussions with select members of the Austrian public. The results show that, from the lab via the media to the general public, communication is characterized by two important tendencies: first, communication becomes increasingly focused on concrete applications of Synthetic Biology; and second, biotechnology represents an important benchmark against which Synthetic Biology is being evaluated

Therapie chronischer Wunden mit wassergefiltertem Infrarot A (wIRA)

The central portion of chronic wounds is often hypoxic and relatively hypothermic, representing a deficient energy supply of the tissue, which impedes wound healing or even makes it impossible. Water-filtered infrared-A (wIRA) is a special form of heat radiation with a high tissue penetration and a low thermal load to the skin surface. wIRA produces a therapeutically usable field of heat and increases temperature, oxygen partial pressure and perfusion of the tissue. These three factors are decisive for a sufficient tissue supply with energy and oxygen and consequently as well for wound healing, especially in chronic wounds, and infection defense. wIRA acts both by thermal and thermic as well as by non-thermal and non-thermic effects. wIRA can advance wound healing or improve an impaired wound healing process and can especially enable wound healing in non-healing chronic wounds. wIRA can considerably alleviate the pain and diminish wound exudation and inflammation and can show positive immunomodulatory effects. In a prospective, randomized, controlled study of 40 patients with chronic venous stasis ulcers of the lower legs irradiation with wIRA and visible light (VIS) accelerated the wound healing process (on average 18 vs. 42 days until complete wound closure, residual ulcer area after 42 days 0.4 cm² vs. 2.8 cm²) and led to a reduction of the required dose of pain medication in comparison to the control group of patients treated with the same standard care (wound cleansing, wound dressing with antibacterial gauze, and compression garment therapy) without the concomitant irradiation. Another prospective study of 10 patients with non-healing chronic venous stasis ulcers of the lower legs included extensive thermographic investigation. Therapy with wIRA(+VIS) resulted in a complete or almost complete wound healing in 7 patients and a marked reduction of the ulcer size in another 2 of the 10 patients, a clear reduction of pain and required dose of pain medication, and a normalization of the thermographic image. In a current prospective, randomized, controlled, blinded study patients with non-healing chronic venous stasis ulcers of the lower legs are treated with compression garment therapy, wound cleansing, wound dressings and 30 minutes irradiation five times per week over 9 weeks. A preliminary analysis of the first 23 patients of this study has shown in the group with wIRA(+VIS) compared to a control group with VIS an advanced wound healing, an improved granulation and in the later phase of treatment a decrease of the bacterial burden. Some case reports have demonstrated that wIRA can also be used for mixed arterial-venous ulcers or arterial ulcers, if irradiation intensity is chosen appropriately low and if irradiation is monitored carefully. wIRA can be used concerning decubital ulcers both in a preventive and in a therapeutic indication. wIRA can improve the resorption of topically applied substances also on wounds. An irradiation with VIS and wIRA presumably acts with endogenous protoporphyrin IX (or protoporphyrin IX of bacteria) virtually similar as a mild photodynamic therapy (endogenous PDT-like effect). This could lead to improved cell regeneration and wound healing and to antibacterial effects. In conclusion, these results indicate that wIRA generally should be considered for the treatment of chronic wounds.Das Zentrum von chronischen Wunden ist oft hypoxisch und relativ hypotherm. Dies entspricht einer defizitären Energiebereitstellung im Gewebe, die die Wundheilung behindert oder unmöglich macht. Wassergefiltertes Infrarot A (wIRA) ist eine spezielle Form der Wärmestrahlung mit hohem Eindringvermögen in das Gewebe bei geringer thermischer Oberflächenbelastung. wIRA erzeugt ein therapeutisch nutzbares Wärmefeld und steigert Temperatur, Sauerstoffpartialdruck sowie die Durchblutung im Gewebe. Diese drei Faktoren sind entscheidend für eine ausreichende Versorgung des Gewebes mit Energie und Sauerstoff und deshalb auch für die Wundheilung, speziell bei chronischen Wunden, und die Infektionsabwehr. wIRA wirkt sowohl über thermische und temperaturabhängige als auch über nicht-thermische und temperaturunabhängige Effekte. wIRA kann die Wundheilung beschleunigen oder einen stagnierenden Wundheilungsprozess verbessern und insbesondere bei nicht-heilenden chronischen Wunden eine Wundheilung ermöglichen. wIRA vermag Schmerzen deutlich zu mindern und die Wundsekretion sowie Entzündung zu reduzieren sowie positive immunmodulierende Effekte zu zeigen. In einer prospektiven, randomisierten, kontrollierten Studie mit 40 Patienten mit chronischen venösen Unterschenkelulzera führte eine Bestrahlung mit wIRA und sichtbarem Licht (VIS) zu einer schnelleren Wundheilung (im Durchschnitt 18 vs. 42 Tage bis zum kompletten Wundschluss, Restulkusfläche nach 42 Tagen 0,4 cm² vs. 2,8 cm²) und einem geringeren Schmerzmittelverbrauch gegenüber einer in gleicher Form (Wundsäuberung, antibakterielle Wundauflagen und Kompressionstherapie) therapierten, aber nicht bestrahlten Kontrollgruppe. Eine weitere prospektive Studie mit 10 Patienten mit aufwändiger thermographischer Verlaufskontrolle ergab unter Therapie mit wIRA(+VIS) eine vollständige oder fast vollständige Abheilung therapierefraktärer chronischer Unterschenkelulzera bei 7 sowie eine deutliche Ulkusverkleinerung bei 2 weiteren der 10 Patienten, eine ausgeprägte Minderung der Schmerzen und des Schmerzmittelverbrauchs und eine Normalisierung des thermographischen Bildes. In einer laufenden prospektiven, randomisierten, kontrollierten, verblindeten Studie werden Patienten mit nicht-heilenden chronischen venösen Unterschenkelulzera mit Kompressionstherapie, Wundsäuberung und nicht-adhäsiven Wundauflagen sowie 30 Minuten Bestrahlung fünfmal pro Woche über 9 Wochen behandelt. Eine vorläufige Auswertung der ersten 23 Patienten zeigte, dass die Gruppe mit wIRA(+VIS) verglichen mit einer Kontrollgruppe mit VIS eine schnellere Wundheilung, eine bessere Granulation und in der späteren Phase der Behandlung eine Abnahme der bakteriellen Last der Wunden aufwies. Einige Fallberichte haben gezeigt, dass wIRA selbst bei gemischt arteriell-venösen Ulzera oder arteriellen Ulzera eingesetzt werden kann, wenn die Bestrahlungsstärke angemessen niedrig gewählt und die Bestrahlung sorgfältig überwacht wird. wIRA kann bei Dekubitalulzera sowohl präventiv als auch therapeutisch eingesetzt werden. wIRA kann die Resorption topisch applizierter Substanzen auch auf Wunden verbessern. Eine Bestrahlung mit VIS und wIRA wirkt vermutlich in Verbindung mit endogenem Protoporphyrin IX (oder Protoporphyrin IX von Bakterien) quasi ähnlich wie eine milde photodynamische Therapie (endogener PDT-ähnlicher Effekt). Dies kann die Zellregeneration und Wundheilung fördern und antibakteriell wirken. Zusammengefasst zeigen die Ergebnisse, dass wIRA generell für die Behandlung chronischer Wunden erwogen werden sollte

The DeMaDs Open Source Modeling Framework for Power System Malfunction Detection

Modeling and simulation of electrical power systems are becoming increasingly important approaches for the development and operation of novel smart grid functionalities -- especially with regard to data-driven applications as data of certain operational states or misconfigurations can be next to impossible to obtain. The DeMaDs framework allows for the simulation and modeling of electric power grids and malfunctions therein. Furthermore, it serves as a testbed to assess the applicability of various data-driven malfunction detection methods. These include data mining techniques, traditional machine learning approaches as well as deep learning methods. The framework's capabilities and functionality are laid out here, as well as explained by the means of an illustrative example.Comment: 2023 Open Source Modelling and Simulation of Energy Systems (OSMSES

A hazardous road towards democracy

Am Fallbeispiel der Demokratischen Republik Kongo (DRK) wird die Entwicklung von einem beinahe gescheiterten Staat in Richtung (Wieder-)Aufbau von staatlichen Institutionen (state building) und Demokratisierung (democratisation), des Übergangs von einem autoritären zu einem demokratischen politischen System, nachgezeichnet. Die wesentliche untersuchte Zeitspanne umfasst die Zeit intensiven demokratischen Wandels zwischen dem Ende des Zweiten Kongokrieges 2002 und den allgemeinen und freien Wahlen im Juli 2006. Konzeptuell die die Arbeit in drei Abschnitte unterteilt: einem Theorieteil, einem Sachverhaltsteil und einem abschließenden Teil mit Schlussfolgerungen. Mehrere theoretische Ansätze verschiedener Autoren werden herangezogen, die miteinander zu einem einheitlichen theoretischen Rahmen verknüpft werden. Besprochen wird insbesondere Francis Fukuyamas state building Ansatz, Edward D. Mansfield und Jack Snyders elite-persuasion und ethnodemocracy Konzepte und Fareed Zakarias Modell der illiberal democracy. Die Situation von Volkswirtschaften mit geringem Wachstum und geringem Pro-Kopf-Einkommen, die auf den Export von wertvollen Rohstoffen angewiesen sind, wird anhand der Arbeit von Paul Collier analysiert. Die Analyse der Gegebenheiten in der DRK kommt zu dem Ergebnis, dass sich die DRK stark dem Modell der illiberal democracy angenähert hat. Es besteht die Gefahr, dass das Land in diesem System verharrt und der Demokratisierungsprozess dadurch einfriert. Den staatlichen Institutionen, die die Verantwortlichkeit insbesondere des Präsidenten der Republik sicherstellen sollten, fehlt es an Unabhängigkeit und Stärke. Es ist ein Fehler, die Abhaltung von allgemeinen und freien Wahlen mit Demokratie gleichzusetzen. Solange die Rechte und Freiheiten der Bürger nicht vor dem unzulässigen Zugriff der Staatsmacht geschützt werden, kann der Demokratisierungsprozess in der DRK nicht als abgeschlossen betrachtet werden

The Stability Challenges of Oxygen Evolving Catalysts: Towards a Common Fundamental Understanding and Mitigation of Catalyst Degradation

Manuscript submitted unter different title: "The Stability Challenges of Oxygen Evolving Electrocatalysts: Towards a Common Fundamental Understanding and Mitigation of Catalyst Degradation"This review addresses the technical challenges, their scientific basis, as well as recent progress and the road ahead with respect to the stability and degradation of OER catalysts operating at electrolyzer anodes in acidic environments with an emphasis on MEA based operation. First, we start clarifying the complexity associated with the term “catalyst stability”, cover today’s performance targets and outline major catalyst degradation mechanisms and their mitigation strategies. Then we evaluate suitable in-situ experimental methods to get insight into catalyst degradation and describe achievements in tuning OER catalyst stability. Finally, we highlight the importance of identifying universal figures of merit for stability and develop a comprehensive accelerated life test (ALT) that would yield comparable performance data across labs and catalyst types. As a whole, this review will help to disseminate and highlight the important relations between structure, composition and stability of OER catalysis under different operating conditions.DFG, 221428535, Nanostructured mixed metal oxides for the electrocatalytic oxidation of waterDFG, 198634447, SPP 1613: Regenerativ erzeugte Brennstoffe durch lichtgetriebene Wasserspaltung: Aufklärung der Elementarprozesse und Umsetzungsperspektiven auf technologische Konzept

Terrain Sketching

Procedural methods for terrain synthesis are capable of creating realistic depictions of heightfield terrains with little user intervention. However, users often do wish to intervene in controlling the placement and shape of landforms, but without sacrificing realism. In this paper, we present a sketching interface to procedural terrain generation. This system enables users to draw the silhouette, spine and bounding curves of both extruding (hills and mountains) and embedding landforms (river courses and canyons). Terrain is interactively generated to match the sketched constraints using multiresolution surface deformation. In addition, the wavelet noise characteristics of silhouette strokes are propagated to the surrounding terrain. With terrain sketching users can interactively create or modify landscapes incorporating varied and complex landforms