The consequences of urban sprawl in a context of decline: the case of Leipzig

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Wegweiser durch den Etikettendschungel

Immer mehr Bio-, Öko- und Umweltlabel auf Waren und Produkten buhlen um die Gunst der Käufer. Doch inzwischen ist längst nicht mehr alles ökologisch korrekt, was unter ökologisch firmiert. Eine Bewertungsagentur für Umweltzeichen könnte Abhilfe schaffen

Easy and convenient millimole‐scale synthesis of new, potential biomarkers for gamma‐hydroxybutyric acid (GHB) intake: Feasible for analytical laboratories

New biomarkers indicating the abuse of drugs and alcohol are still of major interest for clinical and forensic sciences. The endogenous neurotransmitter and approved drug, gamma-hydroxybutyric acid (GHB), is often illegally used for drug-facilitated crimes by spiking GHB into alcoholic beverages. Analytical detection windows of only 6 h in blood and 12 h in urine are often too short to provide reliable proof of GHB ingestion. Therefore, new biomarkers are needed to prove exogenous GHB administration. Previously, amino acid GHB conjugates were discovered in an untargeted metabolomics screening and fatty acid esters with GHB were recently discussed as promising biomarkers to enlarge the analytical detection time windows. However, the development of analytical methods is still slowed down since reference compounds for targeted screenings are still missing. In this paper, we describe simple procedures for the rapid synthesis and purification of amino acid GHB conjugates as well as fatty acid esters, which can be adopted in analytical and clinical/forensic laboratories. Structural characterization data, together with IR, $^1$H-nuclear magnetic resonance (NMR), $^{13}$C-NMR, high-resolution mass spectra (MS), and MS/MS spectra in positive and negative ionization mode are reported for all obtained GHB conjugates and GHB conjugate precursors

Charakteristika und Beurteilungsansätze problemorientierter integrativer Umweltforschung

We analyze a dynamic and stochastic ecological-economic model of grazing management in semi-arid rangelands. The non-equilibrium ecosystem is driven by stochastic precipitation. A risk averse farmer chooses a grazing management strategy under uncertainty such as to maximize expected utility from farming income. Grazing management strategies are rules about which share of the rangeland is given rest depending on the actual rainfall in that year. In a first step we determine the farmer's short-term optimal grazing management strategy. We show that a risk averse farmer chooses a strategy such as to obtain insurance from the ecosystem: the optimal strategy reduces income variability, but yields less mean income than possible. In a second step we analyze the long-run ecological and economic impact of different strategies. We conclude that the more risk averse a farmer is, the more conservative and sustainable is his short-term optimal grazing management strategy, even if he has no specific preference for the distant future. --Ecological-economic model,semi-arid rangeland,grazing management,risk aversion,uncertainty,sustainability

Evaluation problemorientierter integrativer Umweltforschung - Hintergründe, Probleme und Ansätze

Governance has definitely become a very iridescent concept in recent years. The term is widely used, meanwhile, in almost all social-science disciplines as well as in the political process. The intention of this paper is not so much to clarify these sometimes vague meanings but to highlight some special characteristics of environmental governance connected with the restructuring of the spatial dimensions of politics. It starts from the assumption that the quest for multi-level decision making is particularly pressing for environmental governance. However, multi-level governance raises concern about the constitution of various spatial levels and their relationships with each other, as discussed under the term of 'politics of scale'. Moreover, it is argued that for environmental governance the spatial reference is strongly connected with another challenge, which concerns the question of how to deal with the biophysical conditions of particular places? The term landscape governance is introduced to tackle this question without referring to an ontologically given space. Thus, landscape governance deals with the interconnections between socially constructed spaces (the politics of scale) and 'natural' conditions of places. For this task, the concept of societal relationships with nature is introduced and applied to the term 'landscape' as a bridging concept between social and natural sciences. The paper illustrates the approach of landscape governance with examples of problem-oriented interdisciplinary research at the UFZ-Centre for Environmental research in Leipzig, eastern Germany. --Environmental governance,scale,politics of scale,landscape,societal relationships with nature

Evaluation interdisziplinärer Programm-Forschung - Ziele, Anlässe und Prozesse

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Activation of the tryptophan/serotonin pathway is associated with severity and predicts outcomes in pneumonia: results of a long-term cohort study

As part of the immune defense during infection, an increase in enzyme activity of indoleamine 2,3-dioxygenase (IDO) leads to a breakdown of tryptophan to kynurenine. In previous animal studies, therapeutic antagonism of IDO resulted in reduced sepsis mortality. We investigated the prognostic ability of tryptophan, serotonin, kynurenine and IDO (represented by the ratio of kynurenine/tryptophan) to predict adverse clinical outcomes in patients with community-acquired pneumonia (CAP).; We measured tryptophan, serotonin and kynurenine on admission plasma samples from CAP patients included in a previous multicenter trial by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). We studied their association with inflammation (C-reactive protein), infection (procalcitonin) and clinical outcome.; Mortality in the 268 included patients was 45% within 6 years of follow-up. IDO and kynurenine showed a strong positive correlation with markers of infection (procalcitonin) and inflammation (C-reactive protein) as well as sepsis and CAP severity scores. Tryptophan showed similar, but negative correlations. In a multivariate regression analysis adjusted for age and comorbidities, higher IDO activity and lower tryptophan levels were strongly associated with short-term adverse outcome defined as death and/or ICU admission within 30 days with adjusted odds ratios of 9.1 [95% confidence interval (CI) 1.4-59.5, p=0.021] and 0.11 (95% CI 0.02-0.70, p=0.021). Multivariate analysis did not reveal significant associations for kynurenine and serotonin.; In hospitalized CAP patients, higher IDO activity and lower tryptophan levels independently predicted disease severity and short-term adverse outcome. Whether therapeutic modulation of IDO has positive effects on outcome needs further investigation

Dynamik als Leitprinzip zur Revitalisierung des Leipziger Auensystems

10 Thesen zur Revitalisierung der Leipziger Aue, eine Vision, ein konkreter Maßnahmenkatalog mit Karte zu Dynamisierungsoptionen und ein Ausblick mit Realisierungsvorschläge