Interaction as a Lost Art

In today’s day and age, people are consumed by technology. We tend to use phone and email rather than meeting up in person to share the experiences in our lives. It’s easier, more convenient, and quicker, but in-person interaction is a critical key in keeping relationships alive. Body language, tone of voice, and emotional cues are absent or easily taken out of context when using technology to communicate. The use of electronics takes away human presence. This exhibition focused on encouraging the idea of meeting up with people face-to-face whether it’s a long time friend, or a stranger. The mural was designed to encourage you to take pause and reflect on how technology is impacting your life and relationships with others. They were encouraged to take a seat with someone to chat, or to answer the question on the corkboard prompting them to think of who you might reach out to or what you might do to directly connect with someone

Assessing Challenges Associated with Sampling Hexavalent Chromium under New Consensus Guidelilnes

Hexavalent chromium is a corrosion inhibitor found in the primer of most aircraft platforms across the Department of Defense (DoD), from fighter jets to transports. It is also known to cause cancer in humans. Currently, the Occupational Safety and Health Administration (OSHA) legal exposure limit is 5 μg/m3 for workers exposed to hexavalent chromium. A non-regulatory scientific body has recently recommended lowering this exposure level over a factor of ten and sampling with a different sampler that collects particles with the same efficiency as the nose during inhalation. This inhalable sampler collects more particles than the one currently used to comply with OSHA law. An early estimate of the cost of adopting this non-regulatory exposure standard is $900M over five years across the DoD, due in no small part to the likelihood that workers would need new, more restrictive personal protective equipment. Before adopting this new standard, two open points exist: based on DoD processes, is the inhalable sampler necessary and what impact to the sampler efficiency occurs if the flow rate is increased. To answer the first question, real world abrasive blasting processes were sampled and analyzed for particle size distribution. For the second aim, the mass concentrations of samplers operating at their design 2 L/min flow rate were compared to the mass concentrations reported by samplers operating at 6 L/min. From the abrasive blasting processes sample analysis, it was determined use of the inhalable sampler is justified. A 30% positive bias was found when comparing the higher flow rate to the lower flow rate mass concentrations. If the DoD adopts the new recommendation, it is likely over-reporting of hexavalent chromium concentrations in the workplace will occur

Safety of Combined Treatment With Monoclonal Antibodies and Viscum album L Preparations

Combination strategies involving chemotherapy and monoclonal antibodies (mAb) are commonly used in attempts to produce better clinical outcomes. This practice has led to new and ongoing toxicities that may lead to reductions in dose or noncompliance, limiting the effectiveness of treatment. Viscum album L (VA) preparations are widely used in Europe as additive therapy and have been associated with reduced chemotherapy-related adverse reactions and increased health-related quality of life. Concomitant VA therapy might also reduce toxicity related to mAb. This retrospective study investigated the safety of combined treatment with VA and mAb in cancer patients. A total of 43 patients had combined therapy (474 exposures); 12 had VA without mAb (129 exposures), and 8 had mAb without VA (68 exposures). Most patients (89.3%) received concomitant chemotherapy or supportive therapies. A total of 34 patients (60.7%) experienced 142 adverse events (AEs). Leucopenia (14.1% of all events), acneiform rash (8.5%), and stomatitis (6.3%) occurred most frequently. Longitudinal logistic regression analysis suggested a nearly 5 times higher odds of experiencing an AE following treatment with mAb compared with mAb plus VA (95% CI = 1.53-16.14). Our results, together with theoretical consideration of potential botanical-drug interactions, suggest that combined treatment with VA and mAb is safe

Leveraging arbitrary mobile sensor trajectories with shallow recurrent decoder networks for full-state reconstruction

Sensing is one of the most fundamental tasks for the monitoring, forecasting and control of complex, spatio-temporal systems. In many applications, a limited number of sensors are mobile and move with the dynamics, with examples including wearable technology, ocean monitoring buoys, and weather balloons. In these dynamic systems (without regions of statistical-independence), the measurement time history encodes a significant amount of information that can be extracted for critical tasks. Most model-free sensing paradigms aim to map current sparse sensor measurements to the high-dimensional state space, ignoring the time-history all together. Using modern deep learning architectures, we show that a sequence-to-vector model, such as an LSTM (long, short-term memory) network, with a decoder network, dynamic trajectory information can be mapped to full state-space estimates. Indeed, we demonstrate that by leveraging mobile sensor trajectories with shallow recurrent decoder networks, we can train the network (i) to accurately reconstruct the full state space using arbitrary dynamical trajectories of the sensors, (ii) the architecture reduces the variance of the mean-square error of the reconstruction error in comparison with immobile sensors, and (iii) the architecture also allows for rapid generalization (parameterization of dynamics) for data outside the training set. Moreover, the path of the sensor can be chosen arbitrarily, provided training data for the spatial trajectory of the sensor is available. The exceptional performance of the network architecture is demonstrated on three applications: turbulent flows, global sea-surface temperature data, and human movement biomechanics.Comment: 11 pages, 5 figures, 2 table

Creating an enabling environment and accelerating SDGs through increased public funding of innovative agricultural research and development

G20 policymakers should strengthen the enabling environment for innovation in agriculture and food systems to unlock public funds to support researchers in developing their innovations. One way to implement this is through increased public funding for innovative agricultural research and development (R&D) efforts such as the Centre of Excellence in Science, Technology, and Innovation (CoE-STI) of the African Union Development Agency – New Partnership for Africa’s Development (AUDA-NEPAD) and CGIAR Accelerate for Impact Platform (A4IP). CoE-STI brings in a focus on innovation and R&D capacities toward the commercialisation of genome-edited agricultural products to improve livelihoods. CGIAR A4IP promotes the acceleration of the Sustainable Development Goals and food systems progress by valorising and connecting science-based solutions and innovators to deploy impactful solutions on the ground

Design and Characterization of an Aerosol Test Chamber for Emergency Response Patient Contamination Control Simulation and Research

Contaminated or infected patients present a risk of cross-contamination for emergency responders, attending medical personnel and medical facilities as they enter a treatment facility. The controlled conditions of an aerosol test chamber are required to examine factors of contamination, decontamination, and cross-contamination. This study presents the design, construction, and a method for characterizing an aerosol test chamber for a full-sized manikin on a standard North Atlantic Treaty Organization litter. The methodology combined air velocity measurements, aerosol particle counts and size distributions, and computational fluid dynamics modeling to describe the chamber’s performance in three dimensions. This detailed characterization facilitates future experimental design by predicting chamber performance for a variety of patient-focused research

Altered Motoneuron Properties Contribute to Motor Deficits in a Rabbit Hypoxia-Ischemia Model of Cerebral Palsy

Cerebral palsy (CP) is caused by a variety of factors attributed to early brain damage, resulting in permanently impaired motor control, marked by weakness and muscle stiffness. To find out if altered physiology of spinal motoneurons (MNs) could contribute to movement deficits, we performed whole-cell patch-clamp in neonatal rabbit spinal cord slices after developmental injury at 79% gestation. After preterm hypoxia-ischemia (HI), rabbits are born with motor deficits consistent with a spastic phenotype including hypertonia and hyperreflexia. There is a range in severity, thus kits are classified as severely affected, mildly affected, or unaffected based on modified Ashworth scores and other behavioral tests. At postnatal day (P)0–5, we recorded electrophysiological parameters of 40 MNs in transverse spinal cord slices using whole-cell patch-clamp. We found significant differences between groups (severe, mild, unaffected and sham control MNs). Severe HI MNs showed more sustained firing patterns, depolarized resting membrane potential, and fired action potentials at a higher frequency. These properties could contribute to muscle stiffness, a hallmark of spastic CP. Interestingly altered persistent inward currents (PICs) and morphology in severe HI MNs would dampen excitability (depolarized PIC onset and increased dendritic length). In summary, changes we observed in spinal MN physiology likely contribute to the severity of the phenotype, and therapeutic strategies for CP could target the excitability of spinal MNs

Father-daughter Incest: Comparison of Treated Cases to Untreated Control Subjects

Treatment of father daughter incest (FDI) survivors using the victim advocacy/child welfare approach to FDI that predominates today in the US has never been compared to results in untreated control subjects in any published report. In the present study, thirty-two survivors of FDI who received treatment based on the victim advocacy/child welfare approach to FDI were compared to 32 control subjects who did not receive treatment. No significant differences were found using analysis of variance on 21 scales and subscales. Statistical analysis of the data from all 64 of the FDI survivors showed that items reflecting a poor self-image and a history of maternal depression predicted more problematic scores on the depression scale. Those who scored higher on religiosity were less likely to be depressed. Redesigned therapy for FDI aimed, first and foremost, at healing the survivors and validated by prospective randomized trials is needed