An Analysis of the Relationship between Voting Law Stringency and Voter Fraud

The debate on election integrity usually centers upon two competing views. First, the conservative view, makes the claim that combating voter fraud is the most important aspect of preserving election integrity. Conservatives argue that voter fraud is rampant and has a meaningful impact on the outcomes of elections. In order to provide free and secure elections, states need to enact more stringent voting laws. The argument hinges on a correlation between relaxed voting laws and more instances of voter fraud. The second view, held by liberals, is that the conservative argument actually fosters voter suppression, which is more damaging to election integrity, instead of secure elections. Liberals argue that laws need to be relaxed in order to foster more voter turnout, especially among minorities. The argument correlates more stringent voting laws with less voter turnout

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in <em>Saccharomyces cerevisiae</em>

The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we have identified multiple sites of CPC autophosphorylation on yeast Sli15 that are located within its central microtubule-binding domain and examined the functional significance of their phosphorylation by Ipl1 through mutation of these sites, either to non-phosphorylatable alanine (sli15-20A) or to acidic residues to mimic constitutive phosphorylation (sli15-20D). Both mutant sli15 alleles confer chromosome instability, but this is mediated neither by changes in the capacity of Sli15 to activate Ipl1 kinase nor by decreased efficiency of chromosome biorientation, a key process in cell division that requires CPC function. Instead, we find that mimicking constitutive phosphorylation of Sli15 on the Ipl1 phosphorylation sites causes delocalization of the CPC in metaphase, whereas blocking phosphorylation of Sli15 on the Ipl1 sites drives excessive localization of Sli15 to the mitotic spindle in pre-anaphase cells. Consistent with these results, direct interaction of Sli15 with microtubules in vitro is greatly reduced either following phosphorylation by Ipl1 or when constitutive phosphorylation at the Ipl1-dependent phosphorylation sites is mimicked by aspartate or glutamate substitutions. Furthermore, we find that mimicking Ipl1 phosphorylation of Sli15 interferes with the 'tension checkpoint'--the CPC-dependent mechanism through which cells activate the spindle assembly checkpoint to delay anaphase in the absence of tension on kinetochore-microtubule attachments. Ipl1-dependent phosphorylation of Sli15 therefore inhibits its association with microtubules both in vivo and in vitro and may negatively regulate the tension checkpoint mechanism

Laptop Technology in Classrooms: How Student Perceptions Shape Learning and Satisfaction

This study is based on perceptions of students regarding the integration of laptops in classroom endeavors. Empirical findings are based on data collected from a sample of 392 students in undergraduate and graduate universities in twelve states of the USA. Three key findings related to the integration of laptop technology into classrooms of higher education are reported. First relates to student perceptions and feelings surrounding laptop use in the classroom. Secondly, we report how these perceptions vary depending on personal characteristics of students. Lastly, we examine the role these perceptions play in student learning, as well as student satisfaction. Traditionally, laptop technology has been viewed as tool for facilitating note taking. However, our findings indicate that the learning experience is equal, and in some instances greater, when laptops are used to develop a more interactive learning environment, increase information gathering during class time, and enhance classroom discussion

Small Shelly Fossil Preservation and the Role of Early Diagenetic Redox in the Early Triassic

Minute fossils from a variety of different metazoan clades, collectively referred to as small shelly fossils, represent a distinctive taphonomic mode that is most commonly reported from the Cambrian Period. Lower Triassic successions of the western United States, deposited in the aftermath of the end-Permian mass extinction, provide an example of small shelly style preservation that significantly post-dates Cambrian occurrences. Glauconitized and phosphatized echinoderms and gastropods are preserved in the insoluble residues of carbonates from the Virgin Limestone Member of the Moenkopi Formation. Echinoderm plates, spines and other skeletal elements are preserved as stereomic molds; gastropods are preserved as steinkerns. All small shelly style fossils are preserved in the small size fractions of the residues (177 to 420 lm), which is consistent with the size selection of small shelly fossils in the Cambrian. Energy-dispersive X-ray spectra of individual fossils coupled with X-ray diffraction of residues confirm that the fossils are dominantly preserved by apatite and glauconite, and sometimes a combination of the two minerals. The nucleation of both of these minerals requires that pore water redox oscillated between oxic and anoxic conditions, which, in turn, implies that Lower Triassic carbonates periodically experienced oxygen depletion after deposition and during early diagenesis. Long-term oxygen depletion persisted through the Early Triassic, creating diagenetic conditions that were instrumental in the preservation of small shelly fossils in Triassic and, likely, Paleozoic examples

Age and sex-specific rates of leaf regeneration in the Mojave Desert moss Syntrichia caninervis

The extremely skewed female-biased sex ratio in the desert moss Syntrichia caninervis was investigated by assessing the regeneration capacity of detached leaves. Juvenile, green, yellow-green, and brown leaves equating to approximately 0, 2, 6, and 12 yr of age, respectively, were detached from individuals of S. caninervis collected from 10 field populations and grown in a growth chamber for 58 d at a light intensity of 33–128 µmol · m–2 · s–1. Younger leaves (0–2 yr old) tended to have a greater viability, regenerate more quickly, extend their protonemal filaments farther, produce shoots (gametophores) more quickly, produce more shoots, and accumulate a greater biomass than older leaves (6 and 12 yr old). Among younger leaf classes, regenerating female leaves were more likely to produce a shoot than male leaves and produced more shoots than male leaves. The sexes did not differ significantly in time until protonemal emergence, linear extension of protonemata, or rate of biomass accumulation. However, protonemata of male leaves tended to emerge more quickly and produce a greater total biomass, ultimately consisting mostly of protonemata, than did female leaves. The more rapid proliferation of shoots by female leaf regenerants may help to explain the rarity of males in this species

Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES).

The evidence that exposure to ozone air pollution causes acute cardiovascular effects is mixed. We postulated that exposure to ambient levels of ozone would increase blood markers of systemic inflammation, prothrombotic state, oxidative stress, and vascular dysfunction in healthy older subjects, and that absence of the glutathione S-transferase Mu 1 (GSTM1) gene would confer increased susceptibility. This double-blind, randomized, crossover study of 87 healthy volunteers 55-70 years of age was conducted at three sites using a common protocol. Subjects were exposed for 3 h in random order to 0 parts per billion (ppb) (filtered air), 70 ppb, and 120 ppb ozone, alternating 15 min of moderate exercise and rest. Blood was obtained the day before, approximately 4 h after, and approximately 22 h after each exposure. Linear mixed effect and logistic regression models evaluated the impact of exposure to ozone on pre-specified primary and secondary outcomes. The definition of statistical significance was p&lt;0.01. There were no effects of ozone on the three primary markers of systemic inflammation and a prothrombotic state: C-reactive protein, monocyte-platelet conjugates, and microparticle-associated tissue factor activity. However, among the secondary endpoints, endothelin-1, a potent vasoconstrictor, increased from pre- to post-exposure with ozone concentration (120 vs 0 ppb: 0.07 pg/mL, 95% confidence interval [CI] 0.01, 0.14; 70 vs 0 ppb: -0.03 pg/mL, CI -0.09, 0.04; p = 0.008). Nitrotyrosine, a marker of oxidative and nitrosative stress, decreased with increasing ozone concentrations, with marginal significance (120 vs 0 ppb: -41.5, CI -70.1, -12.8; 70 vs 0 ppb: -14.2, CI -42.7, 14.2; p = 0.017). GSTM1 status did not modify the effect of ozone exposure on any of the outcomes. These findings from healthy older adults fail to identify any mechanistic basis for the epidemiologically described cardiovascular effects of exposure to ozone. The findings, however, may not be applicable to adults with cardiovascular disease

Technical Data Package Independent Assessment

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Technical Data Package Independent Assessment

Excerpt from the Proceedings of the Nineteenth Annual Acquisition Research SymposiumThe Program Management Office (PMO) is responsible for the quality and integrity of the data associated with system delivery and performance. When competing a new system or system update, the Program Manager (PM) is required to complete acquisition planning activities for a specific procurement and to develop a well-conceived acquisition strategy. This activity includes developing and validating Technical Data Package (TDP) requirements. Often, the program staff are committed to managing the current system and do not have the resources to fully review and validate the TDP for a major competition. Therefore, the TDP may not represent the best product to industry. A PMO may consider having an outside entity conduct a review of their technical data to assess the readiness and viability of the TDP. An Independent Assessment (IA) may provide significant information for understanding what technical data is available, what data is missing for a competitive solicitation, and what needs to be purchased under a new or follow-on contract. An IA can assist with conducting the first steps in the competitive process of developing requirements and conducting market research. The purpose of an IA is to provide the PMO with additional validation that the TDP is sound for a solicitation and subsequent contract