105 research outputs found
The protein level of isoenergetic formulae does not modulate postprandial insulin secretion in piglets and has no consequences on later glucose tolerance
Early postnatal nutrition is involved in metabolic programming, an excess of protein being suspected to enhance early growth and the propensity to later develop insulin resistance and type 2 diabetes mellitus. The aim of the present study was to test the hypothesis that excessive protein intake during the suckling period would overstimulate the endocrine pancreas in the short term and alter durably its maturation, contributing to the later disruption of glucose homeostasis. Normal-birth-weight and low-birth-weight piglets were fed isoenergetic formulae providing an adequate-protein (AP, equivalent to sow milk) or a high-protein (HP, +48%) supply between 7 and 28d of age and were fed a standard diet until 70d of age. During the formula-feeding period, the HP formula did not modify postprandial insulin secretion but transiently increased fasting insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR, P<0·05). Fasting insulin and HOMA-IR were restored to AP piglets' values 1month after weaning. The structure of the endocrine pancreas was not affected by the protein content of the formula. The weight at birth had no major effect on the studied parameters. We concluded that a high-protein supply during the suckling period does not interfere with insulin secretion and endocrine pancreas maturation in the short term. It has no consequences either on glucose tolerance 1month after weaning. The present study demonstrated that up-regulation of postprandial insulin secretion is not involved in higher growth observed in piglets fed a HP formul
Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models
Régulation vagale de la sécrétion d'insuline chez le porc
*INRA UMRVP Rennes (FRA) Diffusion du document : INRA UMRVP Rennes (FRA) DiplĂ´me : Dr. Ing
Empreinte nutritionnelle et métabolisme glucidique. Influence du microbiote intestinal maternel sur l'homéostasie glucidique de la descendance
Empreinte nutritionnelle et métabolisme glucidique. Influence du microbiote intestinal maternel sur l'homéostasie glucidique de la descendance. GIS Nutrition Alimentation Métabolisme Sant
Régulation vagale de la sécrétion d'insuline chez le porc
RENNES-Agrocampus-CRD (352382323) / SudocSudocFranceF
Quel rôle des composés bioactifs du lait maternel pour la santé de l’enfant et de l’adulte ?
National audienc
Quels bénéfices santé de la matière grasse laitière et des membranes des globules gras du lait (MFGM) dans les préparations pour nourrissons ?
International audienceHuman breast milk (HBM) is the gold standard for the early nutrition of the neonates. The best way to improve infant formulas (IFs) is to mimic both the composition and the structure of HBM components. Supplementation of IF with dairy lipids or bovine milk components such as milk fat globule membrane (MFGM), in partial replacement of plant oils that are currently mainly used, has health benefits for infants. In this article, results of clinical studies on the impact of IF supplementation with MFGM and dairy lipids on psychomotor development and infectious disease prevalence in infants, are reviewed and supported by recent pre-clinical studies. Numerous human studies have reported beneficial effects of MFGM supplementation on neurocognitive development and protection against infectious agents without deleterious impact on growth. Based on rodent and porcine studies, benefits of adding bovine MFGM and dairy lipids in IFs on gut digestion, physiology and protection against pathogens and inflammatory challenges have also been highlighted. However, more randomized controlled trials testing IF supplementation with bovine milk fat, and specifically apolar lipids and associated glycoproteins, are to be performed to increase scientific-based knowledge, address safety concerns, and study its potential programming role of adult health.Le lait de femme est l’aliment le mieux adapté aux besoins du nouveau-né. Il est ainsi l’aliment de référence tant du point de vue de sa composition nutritionnelle que de celui de ses propriétés fonctionnelles, pour améliorer la formulation des préparations pour nourrissons (PPN). L’incorporation dans les PPN de matière grasse provenant de lait de vache ou de certains de ses composants tels que les membranes des globules gras du lait (MFGM pour milk fat globule membrane), en remplacement partiel des huiles végétales qui sont actuellement principalement utilisées, a des effets bénéfiques sur la santé du nouveau-né. Dans cette revue, les résultats des études cliniques sur l’impact des MFGM et de la matière grasse laitière introduits dans les PPN sur le développement psychomoteur et la prévalence des maladies infectieuses et digestives infantiles sont rapportés et étayés par les résultats d’études pré-cliniques récentes. L’incorporation de MFGM dans les PPN apporte un bénéfice sur le développement neurocognitif de l’enfant et une protection vis-à -vis d’agents infectieux, sans modifier sa croissance. L’effet bénéfique de la supplémentation des PPN avec de la matière grasse laitière et des MFGM d’origine bovine sur la digestion et la physiologie intestinale, ainsi que la protection contre des challenges inflammatoires est par ailleurs mis en évidence dans des études précliniques réalisées chez les rongeurs et le porc. Des études complémentaires restent nécessaires pour affiner nos connaissances sur les mécanismes à l’origine de la fonctionnalité spécifique de la matière grasse laitière et en particulier des lipides apolaires et des glycoprotéines associés aux MFGM, et sur leurs effets potentiels sur la programmation de la santé de l’adulte
Health benefits of dairy lipids and MFGM in infant formula
Human breast milk (HBM) is the gold standard for the early nutrition of the neonates. The best way to improve infant formulas (IFs) is to mimic both the composition and the structure of HBM components. Supplementation of IF with dairy lipids or bovine milk components such as milk fat globule membrane (MFGM), in partial replacement of plant oils that are currently mainly used, has health benefits for infants. In this article, results of clinical studies on the impact of IF supplementation with MFGM and dairy lipids on psychomotor development and infectious disease prevalence in infants are reviewed and supported by recent pre-clinical studies. Numerous human studies have reported beneficial effects of MFGM supplementation on neurocognitive development and protection against infectious agents without deleterious impact on growth. Based on rodent and porcine studies, benefits of adding bovine MFGM and dairy lipids in IFs on gut digestion, physiology and protection against pathogens and inflammatory challenges have also been highlighted. However, more randomized controlled trials testing IF supplementation with bovine milk fat, and specifically apolar lipids and associated glycoproteins, must be performed to increase scientific-based knowledge, address safety concerns, and study its potential programming role of adult health
Effects of infant formula composition on long-term metabolic health
International audienceEarly nutrition may have long-lasting metabolic impacts in adulthood. Even though breast milk is the gold standard, most infants are at least partly formula-fed. Despite obvious improvements, infant formulas remain perfectible to reduce the gap between breastfed and formula-fed infants. Improvements such as reducing the protein content, modulating the lipid matrix and adding prebiotics, probiotics and synbiotics, are discussed regarding metabolic health. Numerous questions remain to be answered on how impacting the infant formula composition may modulate the host metabolism and exert long-term benefits. Interactions between early nutrition (composition of human milk and infant formula) and the gut microbiota profile, as well as mechanisms connecting gut microbiota to metabolic health, are highlighted. Gut microbiota stands as a key actor in the nutritional programming but additional well-designed longitudinal human studies are needed
Health benefits of dairy lipids and MFGM in infant formula
Human breast milk (HBM) is the gold standard for the early nutrition of the neonates. The best way to improve infant formulas (IFs) is to mimic both the composition and the structure of HBM components. Supplementation of IF with dairy lipids or bovine milk components such as milk fat globule membrane (MFGM), in partial replacement of plant oils that are currently mainly used, has health benefits for infants. In this article, results of clinical studies on the impact of IF supplementation with MFGM and dairy lipids on psychomotor development and infectious disease prevalence in infants are reviewed and supported by recent pre-clinical studies. Numerous human studies have reported beneficial effects of MFGM supplementation on neurocognitive development and protection against infectious agents without deleterious impact on growth. Based on rodent and porcine studies, benefits of adding bovine MFGM and dairy lipids in IFs on gut digestion, physiology and protection against pathogens and inflammatory challenges have also been highlighted. However, more randomized controlled trials testing IF supplementation with bovine milk fat, and specifically apolar lipids and associated glycoproteins, must be performed to increase scientific-based knowledge, address safety concerns, and study its potential programming role of adult health
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