Pension Reform and Economic Performance in Britain in the 1980s and 1990s

The late 1980s saw a major shift in pension provision in the United Kingdom, when for the first time individuals were permitted to opt out of part of the social security program into individual retirement saving accounts (Personal Pensions). At the same time, membership of company-provided pension plans (occupational schemes) was made voluntary. The paper explores the possible impact of these, and other related changes in social security in the 1980s and 1990s in the UK, on household saving rates, on current and future public finances, on retirement, and on the job mobility of individuals covered by company pension plans.

Globular Clusters in the Sombrero Galaxy (NGC 4594)

The Sombrero galaxy, NGC 4594, contains the most numerous globular cluster system of any nearby spiral. It is an ideal candidate in which to study the globular clusters and contrast them with those in Local Group spirals. Here we present B and I imaging from the CTIO Schmidt telescope which gives a field-of-view of 31' x 31'. Using DAOPHOT we have detected over 400 globular clusters and derived their magnitudes, B--I colors and photometric metallicities. We have attempted to separate our sample into disk and bulge/halo globular cluster populations, based on location in the galaxy. There is some evidence that the disk population is more metal--rich than the bulge/halo globular clusters, however contamination, dust reddening and small number statistics makes this result very tentative. We find that the median metallicity of the bulge/halo globular clusters is [Fe/H] = -0.8. This metallicity is consistent with previous estimates based on smaller samples. It is also similar to the metallicity predicted by the globular cluster metallicity -- galaxy luminosity relation. As with our Galaxy, there is no radial metallicity gradient in the halo globular clusters. This suggests that the spheriodal component of NGC 4594 did not form by a dissipational process.Comment: 7 pages, Latex. To be published in the Astronomical Journal. Full paper available at http://www.ucolick.org/~forbes/home.htm

Toll-like Receptor 2 and 4 (TLR2 and TLR4) Agonists Differentially Regulate Secretory Interleukin-1 Receptor Antagonist Gene Expression in Macrophages

Treatment of macrophages with lipopolysaccharide (LPS) from Gram-negative bacteria or peptidoglycan (PGN) from Gram-positive bacteria activates multiple intracellular signaling pathways and a large, diverse group of nuclear transcription factors. The signaling receptors for PGN and LPS are now known to be the Toll-like receptors 2 and 4 (TLR2 and -4, respectively). While a large body of literature indicates that the members of the TLR family activate nearly identical cytoplasmic signaling programs, several recent reports have suggested that the functional outcomes of signaling via TLR2 or TLR4 are not equivalent. In the current studies, we compared the responses of the secretory IL-1 receptor antagonist (sIL-1Ra) gene to both LPS and PGN. Both LPS and PGN induced IL-1Ra gene expression; however, the combination of both stimuli synergistically increased sIL-1Ra mRNA expression and promoter activity, suggesting that the signals induced by PGN and LPS are not equivalent. While both LPS and PGN utilized the PU.1-binding sites in the proximal sIL-1Ra promoter region to generate a full response, additional distinct promoter elements were utilized by LPS or PGN. Activation of p38 stress-activated protein kinase was required for LPS- or PGN-induced IL-1Ra gene expression, but the p38-responsive promoter elements localized to distinct regions of the sIL-1Ra gene. Additionally, while the LPS-induced, p38-dependent response was dependent upon PU.1 binding, the PGN-induced, p38 response was not. Collectively, these data indicated that while some of the intracellular signaling events by TLR2 and TLR4 agonists are similar, there are clearly distinct differences in the responses elicited by these two bacterial products

Identifying Gaps and Setting Priorities for Employment and Training Research

The report summarizes recent workforce and employment related research, to identify current gaps in employment and training research and makes recommendations for future research processes and priorities that could better inform policy makers, practitioners, job seekers and employers. The report reviews workforce and related research funded by several federal agencies, including the US Departments of Labor, Education, Agriculture, Health and Human Services, and Housing and Urban Development, the National Science Foundation and other federal entities, as well as research undertaken by regional, state and local workforce agencies and philanthrophic organizations

The Hoyle Family: break-up measurements to probe α-condensation in light nuclei

The 12C Hoyle state is a candidate for α-condensation, due to its large volume and αcluster structure. This paper discusses precision break-up measurements and how they can elucidate α-condensate structures. Two experiments are discussed in detail, firstly concerning the break-up of 12C and then the decays of heavier nuclei. With more theoretical input, and increasingly complex detector setups, precision break-up measurements can, in principle, provide insight into the structures of states in α-conjugate nuclei. At present, such searches have not delivered evidence for α-condensation in 12C or 16O

Ideals in a ring

Call number: LD2668 .R4 1965 S65