Craniofaringioma e manejo do pan-hipopituitarismo: Um relato de caso

Craniopharyngiomas are rare benign tumors derived from remnants of Rathke's pouch, located in the suprasellar space. They represent 1 to 3% of all brain tumors, with two predominant incidence age groups: children (5-15 years) and adults (5th decade of life). The main subtypes are papillary and adamantinomatous, the latter being more common. They grow slowly and can invade locally, causing significant morbidity due to mass effect and endocrine complications such as hypopituitarism and hypothalamic obesity. The diagnosis is mainly based on imaging, usually magnetic resonance imaging, which reveals a suprasellar mass capable of compressing the optic chiasm. Symptoms include visual disturbances, headaches and hormonal deficits, especially in children. The case in question involved a 30-year-old man with progressive hemianopsia and headache. After MRI diagnosed a mass lesion measuring 20 x 10 x 10 mm, he underwent transsphenoidal approach for biopsy and subtotal resection, followed by adjuvant radiotherapy. Despite developing panhypopituitarism, treated with hormones and corticosteroids, the patient is asymptomatic after 5 years, with MRI control showing a remaining lesion measuring 5 x 4 x 6 mm. In short, craniopharyngiomas, despite being benign, present significant challenges due to their complex location and potential complications. Therapeutic management involves decisions between different surgical and radiotherapy approaches, with special attention to preserving quality of life, especially in young patients. Early diagnosis and a multidisciplinary approach are essential to optimize results and ensure adequate follow-up.Craniofaringiomas são tumores benignos raros derivados de remanescentes da bolsa de Rathke, localizados no espaço suprasselar. Representam de 1 a 3% de todos os tumores cerebrais, com duas faixas etárias de incidência predominantes: crianças (5-15 anos) e adultos (5ª década de vida). Os subtipos principais são papilar e adamantinomatoso, sendo este último mais comum. Eles crescem lentamente e podem invadir localmente estruturas adjacentes, causando morbidade significativa devido ao efeito de massa e complicações endócrinas como hipopituitarismo e obesidade hipotalâmica. O diagnóstico baseia-se principalmente em exame de imagem, geralmente ressonância magnética, que revela uma massa suprasselar capaz de comprimir o quiasma óptico. Os sintomas incluem distúrbios visuais, dores de cabeça e déficits hormonais, especialmente em crianças. O caso em questão envolveu um homem de 30 anos com hemianopsia progressiva e cefaleia. Após ressonância magnética diagnosticar uma lesão expansiva de 20 x 10 x 10 mm, ele foi submetido à abordagem transesfenoidal para biópsia e ressecção subtotal, seguida por radioterapia adjuvante. Apesar de desenvolver panhipopituitarismo, tratado com hormônios e corticosteroides, o paciente está assintomático após 5 anos, com controle de ressonância mostrando uma lesão remanescente de 5 x 4 x 6 mm. Em suma, o craniofaringioma, apesar de benigno, apresenta desafios significativos devido à sua complexa localização e potenciais complicações. O manejo terapêutico envolve decisões entre diferentes abordagens cirúrgicas, radioterápicas e medicamentosas com atenção especial para preservar a qualidade de vida, especialmente em pacientes jovens. O diagnóstico precoce e a abordagem multidisciplinar são fundamentais para otimizar os resultados e garantir um acompanhamento adequado

Transtornos psiquiátricos prevalentes na infância: lidando com desafios comportamentais.

Objective: This study aims to synthesize the evidence on psychiatric disorders in childhood, identifying intervention strategies. The aim is to offer a comprehensive view to guide clinical practices and promote understanding of these conditions. Methodology: The careful selection of the integrative review through critical reading and comprehensive analysis of articles aims to synthesize evidence on psychiatric disorders in childhood and intervention strategies, contributing to a practical understanding of these conditions, through the health descriptors: “Psychiatric Disorders”, “Behavioral Disorders”, “Child Psychiatry”. Results: The comparative analysis of psychiatric disorders in childhood reveals patterns and differences in therapeutic approaches, covering conditions such as ADHD, ASD, GAD and OCD. The coexistence of multiple disorders amplifies the complexity of treatment, requiring an integrated approach. Practitioners face the challenge of personalizing interventions, emphasizing the need for collaboration and adaptation in the holistic management of conditions. Conclusion: In conclusion, understanding the therapeutic nuances and challenges associated with co-existing childhood psychiatric disorders highlights the importance of personalized approaches and interdisciplinary collaboration to optimize treatment and improve children's well-being. The flexibility and adaptability of professionals are fundamental to face the complexity of these conditions.Objetivo: Este estudo visa sintetizar as evidências sobre transtornos psiquiátricos na infância, identificando estratégias de intervenção. Busca-se oferecer uma visão abrangente para orientar práticas clínicas e promover o entendimento dessas condições. Metodologia: A seleção criteriosa da revisão integrativa por meio da leitura crítica e análise abrangente de artigos visam sintetizar evidências sobre transtornos psiquiátricos na infância e estratégias de intervenção, contribuindo para uma compreensão prática dessas condições, através dos descritores de saúde: “Transtornos Psiquiátricos”, “Transtornos de Comportamento”, “Psiquiatria Infantil”. Resultados: A análise comparativa de transtornos psiquiátricos na infância revela padrões e diferenças nas abordagens terapêuticas, abrangendo condições como TDAH, TEA, TAG e TOC. A coexistência de múltiplos transtornos amplifica a complexidade do tratamento, exigindo uma abordagem integrada. Profissionais enfrentam o desafio de personalizar intervenções, enfatizando a necessidade de colaboração e adaptação na gestão holística das condições. Conclusão: Em conclusão, a compreensão das nuances terapêuticas e desafios associados à coexistência de transtornos psiquiátricos na infância destaca a importância de abordagens personalizadas e da colaboração interdisciplinar para otimizar o tratamento e melhorar o bem-estar das crianças. A flexibilidade e adaptabilidade dos profissionais são fundamentais para enfrentar a complexidade dessas condições

Intimate archives: rethinking gender in African Studies

On 14 April 2021, the Governing Intimacies: Sexualities, Gender and Governance in the Postcolonial World research project, convened by Associate Professor Srila Roy at the University of the Witwatersrand, Johannesburg, hosted a webinar discussion between Oluwakemi M. Balogun (University of Oregon), Simidele Dosekun (London School of Economics), and Jacqueline-Bethel Tchouta Mougoué (University of Wisconsin) about their recently published books: Beauty Diplomacy: Embodying an Emerging Nation (Balogun, 2020); Fashioning Postfeminism: Spectacular Femininity and Transnational Culture (Dosekun, 2020), and Gender, Separatist Politics and Embodied Nationalism in Cameroon (Mougoué, 2019). The webinar was organised and hosted by Professor Srila Roy and Dr Caio Simões De Araújo

Perfil do docente universitário em educação física: uma discussão sobre os saberes de sua formação / Profile of university teachers in physical education: a discussion about the knowlegde of their formation

O debate acerca dos saberes docentes no âmbito das licenciaturas mostra-se cada vez mais pertinente, uma vez que, nestes espaços, ainda encontramos professores formadores com práticas pedagógicas ancoradas em uma visão linear; unilateral; vertical e fragmentada do saber ensinar. Esta inferência fomentou o desejo em traçar o perfil profissiográfico do professor universitário em Educação Física no que tange a interface com as trajetórias profissionais, formativas e expressão dos saberes docentes. Optou-se por uma pesquisa de campo com abordagem qualitativa envolvendo 13 professores do curso de licenciatura em Educação Física de uma universidade pública do Ceará. Através de um questionário foram obtidos dados referentes a idade e sexo, percurso formativo, experiência profissional anterior à docência universitária A interpretação dos dados foi subsidiada pelo método estatística descritiva simples, permitindo ampla visão dos resultados e identificação de três categorias de análise: 1. Sexo e idade, 2. Formação, 3. Atuação docente. Os dados revelaram que o perfil do docente universitário é formado em sua maioria por homens, com idades entre 36 e 55 anos, com formação situada no campo das ciências biológicas e atuação profissional anterior à docência universitária em ambiente não-escolar. Infere-se que houve maior investimento no campo disciplinar relacionado à área do bacharelado em detrimento do campo pedagógico de constituição do ser docente. Portanto, conclui-se que a trajetória profissional vinculada ao campo escolar prevaleceu no ensino pré-universitário, assim como uma reflexão sobre esta construção.

Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis

Background: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. Methods: Two randomized groups of hemodialysis patients: control (CTL, n = 76/F36; 66.33 ± 3.88 years) and RT (n = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes—SF36), and Beck Depression Inventory was applied. Results: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; p = 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; p = 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT,680.8 ± 225.2 vs. CTL,589.5 ± 195.9; p = 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; p = 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; p = 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; p = 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; p = 0.001). Quality of life and mental health increased (p = 0.001) for RT, but did not change for CTL (p = 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip (p = 0.001). Conclusions: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients

Functional diversity mediates macroecological variation in plant–hummingbird interaction networks

Aim: Species interaction networks are known to vary in structure over large spatial scales. We investigated the hypothesis that environmental factors affect interaction network structure by influencing the functional diversity of ecological communities. Notably, we expect more functionally diverse communities to form interaction networks with a higher degree of niche partitioning. Locatio

Núcleos de Ensino da Unesp: artigos 2007

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora