Symmetry Constrained Two Higgs Doublet Models

We study Two-Higgs-Doublet Models (2HDM) where Abelian symmetries have been introduced, leading to a drastic reduction in the number of free parameters in the 2HDM. Our analysis is inspired in BGL models, where, as the result of a symmetry of the Lagrangian, there are tree-level scalar mediated Flavour-Changing-Neutral-Currents, with the flavour structure depending only on the CKM matrix. A systematic analysis is done on the various possible schemes, which are classified in different classes, depending on the way the extra symmetries constrain the matrices of couplings defining the flavour structure of the scalar mediated neutral currents. All the resulting flavour textures of the Yukawa couplings are stable under renormalisation since they result from symmetries imposed at the Lagrangian level. We also present a brief phenomenological analysis of the most salient features of each class of symmetry constrained 2HDM.Comment: 30 pages, 5 Table

Feasibility Study on the Use of the Internet for Traffic of Unclassified Data

This research compares two possible networking methods for connecting all Brazilian Air Force Materiel Command units responsible for support and operation of Brazilian Air Force\u27s weapons systems. The network includes the use of dedicated X.25 links, and the use of a virtual Private Network using the Internet (TCP/IP) as the medium of transmission. The Brazilian Air Force Materiel Command, responsible to support operating units over a very large sparse territory, lacks an efficient media of computer communications, which makes it difficult to control the supply chain channels of materiel present in each unit, depots, and warehouses. We studied the network infrastructure necessary to solve this problem, and proposed two different scenarios. One uses the current level of technology based on dedicated X.25 environment, and the other uses the incipient Virtual Private Networking technology and the Internet as the communication medium. The results suggest that the Brazilian Air Force could be able to use the Internet and VPN technology in a moderated secure environment (C2 Level), and could save more than $100,000 per month in comparison to the implementation of the same level of networking using the present X.25 model. This study concludes that the BAF may benefit from the use of the VPN model in a secure and less costly environment, while maintaining the necessary flexibility and high performance to operate in the newly paradigm of distributed environments. Other implications for the Brazilian Air Force regarding Information Warfare issues and recommendations for further study are discussed

Quantitative Proteomic Analysis Reveals Changes in the Benchmark Corynebacterium pseudotuberculosis Biovar Equi Exoproteome after Passage in a Murine Host

Corynebacterium pseudotuberculosis biovar equi is the etiologic agent of ulcerative lymphangitis. To investigate proteins that could be related to the virulence of this pathogen, we combined an experimental passage process using a murine model and high-throughput proteomics with a mass spectrometry, data-independent acquisition (LC-MSE) approach to identify and quantify the proteins released into the supernatants of strain 258_equi. To our knowledge, this approach allowed characterization of the exoproteome of a C. pseudotuberculosis equi strain for the first time. Interestingly, the recovery of this strain from infected mouse spleens induced a change in its virulence potential, and it became more virulent in a second infection challenge. Proteomic screening performed from culture supernatant of the control and recovered conditions revealed 104 proteins that were differentially expressed between the two conditions. In this context, proteomic analysis of the recovered condition detected the induction of proteins involved in bacterial pathogenesis, mainly related to iron uptake. In addition, KEGG enrichment analysis showed that ABC transporters, bacterial secretion systems and protein export pathways were significantly altered in the recovered condition. These findings show that secretion and secreted proteins are key elements in the virulence and adaptation of C. pseudotuberculosis. Collectively, bacterial pathogenesis-related proteins were identified that contribute to the processes of adherence, intracellular growth and evasion of the immune system. Moreover, this study enhances our understanding of the factors that may influence the pathogenesis of C. pseudotuberculosis.Fil: Marques Da Silva, Wanderson. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; Brasil. Institut National de la Recherche Agronomique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carvalho, Rodrigo D. De Oliveira. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Dorella, Fernanda A.. Universidade Federal de Minas Gerais; BrasilFil: Folador, Edson L.. Universidade Federal da Paraíba. Centro de Biotecnologia; BrasilFil: Souza, Gustavo H. M. F.. Waters Corporation; BrasilFil: Pimenta, Adriano M. C.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Figueiredo, Henrique C. P.. Universidade Federal de Minas Gerais; BrasilFil: Le Loir, Yves. Institut National de la Recherche Agronomique; FranciaFil: Silva, Artur. Universidade Federal do Pará; BrasilFil: Azevedo, Vasco. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; Brasi