An investigation of the surface and bulk nitration of cellulose

Modern analytical techniques have been employed to investigate the nitration reaction of cellulose. The nitronium ion, NO(_2)(^+), is shown to be the important nitrating species of cellulose in the nitrating media employed. In mixes of high nitronium ion concentration, nitration at the cellulose surface is observed, by ESCA, to be extremely rapid, while in mixes of low nitronium ion concentration it is observed to be comparatively slow. It is shown that the degree of substitution (DOS) achieved at the fibre surface is equilibrium controlled. However, it is also shown that cellulose morphology plays an important role in determining the final bulk DOS achieved by nitration. The surface and bulk nitration of cellulose in dichloromethane/nitric acid mixes has been investigated by a variety of techniques. (^13)C solution state nmr has been employed to monitor the partial DOS established at the individual sites of the anhydroglucose residues. The substitution distribution patterns observed for materials in the DOS range 1.8 → 2.4 are very dependent on the nitrating media employed. Further, the differences in the substitution distribution pattern are reflected in the d(l0l) mean interchain spacing. A possible explanation for these differences is forwarded. The plasma etching of cellulose nitrate has been investigated as a function of DOS. The influence of sulphate ester residues on etch rate is also considered

Retained Ownership of Beef Cattle When Considering Production and Price Risk

Livestock Production/Industries,

Where physics meets chemistry:thin film deposition from reactive plasmas

Functionalising surfaces using polymeric thin films is an industrially important field. One technique for achieving nanoscale, controlled surface functionalization is plasma deposition. Plasma deposition has advantages over other surface engineering processes, including that it is solvent free, substrate and geometry independent, and the surface properties of the film can be designed by judicious choice of precursor and plasma conditions. Despite the utility of this method, the mechanisms of plasma polymer growth are generally unknown, and are usually described by chemical (i.e., radical) pathways. In this review, we aim to show that plasma physics drives the chemistry of the plasma phase, and surface-plasma interactions. For example, we show that ionic species can react in the plasma to form larger ions, and also arrive at surfaces with energies greater than 1000 kJ∙mol–1 (>10 eV) and thus facilitate surface reactions that have not been taken into account previously. Thus, improving thin film deposition processes requires an understanding of both physical and chemical processes in plasma

Seismic imaging of the Alaska subduction zone: implications for slab geometry and volcanism

Alaska has been a site of subduction and terrane accretion since the mid‐Jurassic. The area features abundant seismicity, active volcanism, rapid uplift, and broad intraplate deformation, all associated with subduction of the Pacific plate beneath North America. The juxtaposition of a slab edge with subducted, overthickened crust of the Yakutat terrane beneath central Alaska is associated with many enigmatic volcanic features. The causes of the Denali Volcanic Gap, a 400‐km‐long zone of volcanic quiescence west of the slab edge, are debated. Furthermore, the Wrangell Volcanic Field, southeast of the volcanic gap, also has an unexplained relationship with subduction. To address these issues, we present a joint ambient noise, earthquake‐based surface wave, and P‐S receiver function tomography model of Alaska, along with a teleseismic S wave velocity model. We compare the crust and mantle structure between the volcanic and nonvolcanic regions, across the eastern edge of the slab and between models. Low crustal velocities correspond to sedimentary basins, and several terrane boundaries are marked by changes in Moho depth. The continental lithosphere directly beneath the Denali Volcanic Gap is thicker than in the adjacent volcanic region. We suggest that shallow subduction here has cooled the mantle wedge, allowing the formation of thick lithosphere by the prevention of hot asthenosphere from reaching depths where it can interact with fluids released from the slab and promote volcanism. There is no evidence for subducted material east of the edge of the Yakutat terrane, implying the Wrangell Volcanic Field formed directly above a slab edge

Cell sheets in cell therapies

This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing biological substrates. Synthetic surfaces provide a far more versatile system for culturing and delivering cell sheets. This has the potential to positively affect quality, and efficient, localized cell delivery has a significant impact on patient outcome and on the overall cost of goods. We highlight current applications of these advanced carriers and future applications of these surfaces and cell sheets with an emphasis both on clinical use and regulatory requirements

The XMM Cluster Survey: Evidence for energy injection at high redshift from evolution of the X-ray luminosity-temperature relation

We measure the evolution of the X-ray luminosity-temperature (L_X-T) relation since z~1.5 using a sample of 211 serendipitously detected galaxy clusters with spectroscopic redshifts drawn from the XMM Cluster Survey first data release (XCS-DR1). This is the first study spanning this redshift range using a single, large, homogeneous cluster sample. Using an orthogonal regression technique, we find no evidence for evolution in the slope or intrinsic scatter of the relation since z~1.5, finding both to be consistent with previous measurements at z~0.1. However, the normalisation is seen to evolve negatively with respect to the self-similar expectation: we find E(z)^{-1} L_X = 10^{44.67 +/- 0.09} (T/5)^{3.04 +/- 0.16} (1+z)^{-1.5 +/- 0.5}, which is within 2 sigma of the zero evolution case. We see milder, but still negative, evolution with respect to self-similar when using a bisector regression technique. We compare our results to numerical simulations, where we fit simulated cluster samples using the same methods used on the XCS data. Our data favour models in which the majority of the excess entropy required to explain the slope of the L_X-T relation is injected at high redshift. Simulations in which AGN feedback is implemented using prescriptions from current semi-analytic galaxy formation models predict positive evolution of the normalisation, and differ from our data at more than 5 sigma. This suggests that more efficient feedback at high redshift may be needed in these models.Comment: Accepted for publication in MNRAS; 12 pages, 6 figures; added references to match published versio

Tracking the Penetration of Plasma Reactive Species in Tissue Models

Electrically generated cold atmospheric plasma is being intensively researched for novel applications in biology and medicine. Significant attention is being given to reactive oxygen and nitrogen species (RONS), initially generated upon plasma–air interactions, and subsequently delivered to biological systems. Effects of plasma exposure are observed to millimeter depths within tissue. However, the exact nature of the initial plasma–tissue interactions remains unknown, including RONS speciation and delivery depth, or how plasma-derived RONS intervene in biological processes. Herein, we focus on current research using tissue and cell models to learn more about the plasma delivery of RONS into biological environments. We argue that this research is vital in underpinning the knowledge required to realize the full potential of plasma in biology and medicine

Limiting Pseudomonas aeruginosa Biofilm Formation Using Cold Atmospheric Pressure Plasma

We investigate the ability to disrupt and limit growth biofilms of Pseudomonas aeruginosa using application of cold atmospheric pressure (CAP) plasma. The effect of the bio-film's exposure to a helium (CAP) jet was assessed at varying time points during biofilm maturation. Results showed that the amount of time during biofilm growth that CAP pressure was applied has a crucial role on the ability of biofilms to mature and recover after CAP exposure. Intervention during the early stages of biofilm formation (0-8 h) results in a 4-5-log reduction in viable bacterial cells (measured at 24 h of incubation) relative to untreated biofilms. However, CAP treatment of biofilm at 12 h and above only results in a 2-log reduction in viable cells. This has potentially important implications for future clinical application of CAP to treat infected wounds