Enantioselective Protonation of Ketene Bis(trimethylsilyl) Acetals Derived from α-Aryl-α-haloacetic Acids Using LBA

Optically active α-halocarboxylic acids and derivatives are important and versatile building blocks in organic synthesis. Lewis acid assisted chiral Brönsted acid (LBA) was recently prepared in situ from tin(IV) tetrachloride and optically pure binaphthol and shown to be an effective reagent for enantioselective protonation of pro- chiral silyl enol ethers and ketene bis(trialkylsilyl) acetals. In this paper we describe highly enantioselective protonation of ketene bis(trimethylsilyl) acetals prepared from α-aryl-α-haloaeetic acids using LBA. This is a new methodology for the enantioselective synthesis of α-aryl-α-haloacetic acid derivatives, and the commercially available chiral binaphthol can be recovered efficiently for reuse

Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition

ArticleJOURNAL OF ANESTHESIA. 24(2):328-332 (2010)journal articl

Far-infrared rays control prostate cancer cells _in vitro_ and _in vivo_

We introduce a new effective method to control hormone refractory prostate cancer cells by using an activated rubber/resin form (RB), far-infrared ray emitter, with or without sodium butyrate (SB). The growth of three human prostate cancer cell lines (Du145, PC-3 and LNCaP) was suppressed _in vitro_ and _in vivo_ by using RB, and the cells were eradicated with RB + 3 mM SB. G1 arrest and apoptotic pathway proteins were induced by RB with intensified expressions of apoptosis - related mRNA on cDNA microarray. RB radiates the infra-red rays of the 4 to 25 [mu]m wavelengths to an object which exert a favorable influence on a cancer control. These results may render us a new therapeutic modality in hormone refractory prostate cancer

Nucleation process in the Burridge-Knopoff model of earthquakes

Nucleation process of the one-dimensional Burridge-Knopoff model of earthquakes obeying the rate- and state-dependent friction law is studied both analytically and numerically. The properties of the nucleation dynamics, the nucleation lengths and the duration times are examined together with their continuum limits.Comment: Title changed, one figure (previous Fig.2) omitted, several references (new Refs.5-8,21,24-28) added, and two eqs. (new eqs.1,5) added. Text expanded considerably, especially the part explaining the relation of the model to the elastic continuum model. To appear in Europhys. Letter

Prostate Biopsy May Not Be Indicated Early after Bacillus Calmette Guérin Treatment

Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients’ PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful