Chemical freeze-out parameters via functional renormalization group approach

We study the freeze-out parameters in a QCD-assisted effective theory that accurately captures the quantum and in-medium effects of QCD at low energies. Functional renormalization group approach is implemented in our work to incorporate the non-perturbative quantum, thermal and density fluctuations. By analyzing the calculated baryon number susceptibility ratios $\chi_{2}^{B}/\chi_{1}^{B}$ and $\chi_{3}^{B}/\chi_{2}^{B}$, we determine the chemical freeze-out temperatures and baryon chemical potentials in cases of hard thermal or dense loop improved $\mu$-dependent glue potential and $\mu$-independent glue potential. We calculate the ${\chi_{4}^{B}}/{\chi_{2}^{B}}\, (\kappa \sigma^{2})$ and ${\chi_{6}^{B}}/{\chi_{2}^{B}}$ along the freeze-out line for both cases. It's found that $\kappa \sigma^{2}$ exhibits a nonmonotonic behavior in low collision energy region and approach to one for lower collision energy. ${\chi_{6}^{B}}/{\chi_{2}^{B}}$ shows a similar complicated behavior in our calculation.Comment: 14 pages, 11 figures, 7 table

Comparative study of gamma-ray emission from molecular clouds and star-forming galaxies

Star-forming regions on different scales, such as giant molecular clouds in our Galaxy and star-forming galaxies, emit GeV gamma-rays. These are thought to originate from hadronic interactions of cosmic-ray (CR) nuclei with the interstellar medium. It has recently been shown that the gamma-ray luminosity ($L_\gamma$) of star-forming galaxies is well correlated with their star formation rates (SFR). We investigated \textsl{Fermi} data of eight Galactic molecular clouds in the Gould belt and found that molecular clouds do not follow the $L_\gamma-{\rm SFR}$ correlation of star-forming galaxies. We also compared the scaling relations of gamma-ray luminosity, SFR, and the gas mass for molecular clouds and star-forming galaxies. Using a multiple-variable regression analysis, we found different dependences of gamma-ray emission on SFR or mass for molecular clouds and star-forming galaxies. This suggests that different mechanisms may govern the production of gamma-rays in these two types of sources. Specifically, the strong dependence on mass supports that gamma-ray emission of molecular clouds primarily comes from {\em \textup{passive}} interaction by diffuse Galactic CRs, whereas the strong dependence on SFR supports that gamma-ray emission of star-forming galaxies originates from CRs that are accelerated by local {\em \textup{active}} sources.Comment: Accepted for publication in Astronomy & Astrophysic

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency. Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex (SEC) used by the viral encoded Tat protein to activate HIV transcription. Amt-87 does so by promoting the phosphorylation of CDK9 at the T-loop, liberating P-TEFb from the inactive 7SK snRNP, and inducing the formation of the Tat-SEC complex at the viral promoter. Together, our data reveal chalcones as a promising category of compounds that should be further explored to identify effective LRAs for targeted reversal of HIV latency

Manifold formation and crossings of ultracold lattice spinor atoms in the intermediate interaction regime

Ultracold spinor atoms in the weak and strong interaction regime have received extensive investigations, while the behavior in the intermediate regime is less understood. We numerically investigate ultracold spinor atomic ensembles of finite size in the intermediate interaction regime, and reveal the evolution of the eigenstates from the strong to the intermediate regime. In the strong interaction regime, it has been well known that the low-lying eigenenergy spectrum presents the well-gaped multi-manifold structure, and the energy gaps protect the categorization of the eigenstates. In the intermediate interaction regime, it is found that the categorization of the eigenstates is preserved, and the eigenenergy spectrum become quasi-continuum, with different manifolds becoming overlapped. The overlapping induces both direct and avoided crossings between close-lying manifolds, which is determined by the combined symmetries of the eigenstates involved in the crossing. A modified t-J model is derived to describe the low-lying eigenstates in the intermediate regime, which can capture the formation and crossings of the manifolds. State preparation through the avoided crossings is also investigated.Comment: 8 pages,6 figure

Detrimental effect of Bisphenol S in mouse germ cell cyst breakdown and primordial follicle assembly

The female reproductive lifespan is largely determined by the size of primordial follicle pool, which is established in early life. Bisphenol S (BPS), frequently present in plastic products used in daily life, has been demonstrated as an exogenous estrogen-like endocrine disrupting chemical interfering with the endocrine and reproductive systems. However, the molecular mechanisms of its reproductive toxicity remain to be determined. In the present study, we focused on the effect of BPS on the early ovarian folliculogenesis of mice. Our in vivo experiments showed that the treatment with BPS at 2 and 10 μg/kg body weight/day for 3 days induced abnormal germ cell cyst breakdown and primordial follicle assembly in the mouse ovary, further affecting later ovarian differentiation and reducing oocyte quality. In addition, our in vitro study demonstrated that BPS could interact with estrogen receptors (ERs) to induce phosphorylation of JNKs, which is responsible for reducing oocyte adhesion in cysts. Meanwhile, BPS exposure up-regulated Notch signaling pathway to increase the proliferation of granulosa cells precursors. Our study provided new evidence for the adverse effects of BPS on female reproduction, especially after perinatal exposure, and elucidated how it works

Malignant Mesothelioma Presenting as a Giant Chest, Abdominal and Pelvic Wall Mass

Malignant mesothelioma (MM) is a relatively rare carcinoma of the mesothelial cells, and it is usually located in the pleural or peritoneal cavity. Here we report on a unique case of MM that developed in the chest, abdominal and pelvic walls in a 77-year-old female patient. CT and MRI revealed mesothelioma that manifested as a giant mass in the right flank and bilateral pelvic walls. The diagnosis was confirmed by the pathology and immunohistochemistry. Though rare, accurate investigation of the radiological features of a body wall MM may help make an exact diagnosis

Interaction effects of pseudospin-based magnetic monopoles and kinks in a doped dipolar superlattice gas

Magnetic monopoles and kinks are topological excitations extensively investigated in quantum spin systems, but usually they are studied in different setups. We explore the conditions for the coexistence and the interaction effects of these quasiparticles in the pseudospin chain of the atomic dipolar superlattice gas. In this chain, the magnetic kink is the intrinsic quasiparticle, and the particle/hole defect takes over the role of the north/south magnetic monopole, exerting monopolar magnetic fields to neighboring spins. A confinement effect between the monopole and kink is revealed, which renormalizes the dispersion of the kink. The corresponding dynamical deconfinement process is observed and arises due to the kink-antikink annihilation. The rich interaction effects of the two quasiparticles could stimulate corresponding investigations in bulk spin systems

Magnetic monopole induced polarons in atomic superlattices

Magnetic monopoles have been realized as emergent quasiparticles in both condensed matter and ultracold atomic platforms, with growing interests in the coupling effects between the monopole and different magnetic quasiparticles. In this work, interaction effects between monopoles and magnons are investigated for an atomic pseudospin chain. We reveal that the monopole can excite a virtual magnon cloud in the paramagnetic chain, thereby giving rise to a new type of polaron, the monopole-cored polaron (McP). The McP is composed of the monopole as the impurity core and the virtual magnon excitation as the dressing cloud. The magnon dressing facilitates the Dirac string excitation and impacts the monopole hopping. This induces an anti-trapping effect of the McP, which refers to the fact that the dressing enhances the mobility of the McP, in contrast to the self-trapping of the common polarons. Moreover, heterogeneous bipolarons are shown to exist under the simultaneous doping of a north and a south monopole. The heterogeneous bipolaron possesses an inner degree of freedom composed of two identical impurities. Our investigation sheds light on the understanding of how the coupling between the impurity core and the dressing cloud can engineer the property of the polaro