Creating a Unified Digital Communication Strategy with Chicago Farmers Market Collective

CMFC is a group of independent farmers markets throughout Chicago that work together to get fresh produce to consumers. They need a way to digitally market their company so the message can be clearly advertised to their target market and beyond

The antimicrobial potential of Streptomyces from insect microbiomes

Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.National Institutes of Health/[NIH U19 Al109673]/NIH/Estados UnidosNational Institutes of Health/[NIH U19 TW009872]/NIH/Estados UnidosUniversidad de Costa Rica/[801-B0-538]/UCR/Costa RicaUniversidad de Costa Rica/[810-B3-185]/UCR/Costa RicaThe São Paulo Research Foundation/[#2013/50954-0]/FAPESP/BrasilThe São Paulo Research Foundation/[#2014/14095-6]/FAPESP/BrasilNational Research Service Award/[T32 GM008505]/NIDCD/Estados UnidosNational Science Foundation/[MCB-0702025]/NSF/Estados UnidosUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC